The evolution of parenteral nutrition over the past 40 years: A bibliometric overview

Abstract

Background/Aim: Malnutrition remains a significant problem in cancer patients, intensive care patients, and patients undergoing major surgery. Although the importance of nutritional support has been proven, the preferred route for nutrient delivery is still controversial. In recent years, the use of parenteral nutrition (PN) has been increasing, and the early use of PN has become widespread once again. However, there is still no bibliometric study in the literature about PN, which has increased the number of global studies in recent years. This study aimed to analyze the scientific articles on PN published between 1980 and 2020 with statistical methods and to evaluate the subject holistically. Methods: Articles on PN published between 1980 and 2020 were analyzed using statistical and bibliometric methods. Spearman correlation coefficient was used for correlation studies. Nonlinear (cubic model) regression analysis was used to estimate the number of publications in the coming years. Keyword network visualization maps were used to identify trending topics and collaborations. Results: A total of 9424 publications were found. Of these publications, 5461 (57.9%) were articles. The top 3 contributing countries to the literature were the USA (1901, 34.8%), UK (542, 10%), and France (437, 8%). The top 3 most active institutions were Harvard University (99, 1.8%), University of Toronto (98, 1.8%), and University of California, Los Angeles (84, 1.5%). The top 3 journals with the highest number of publications were Journal of Parenteral and Enteral Nutrition (894, 16.4%), Clinical Nutrition (337, 6.2%), and Nutrition (187, 3.4%). According to the average number of citations per article, the most influential journals were Annals of Surgery (88.2, 1.5%), Gastroenterology (85.8), and Gut (81.2), respectively. Conclusion: In this comprehensive study on PN, a summary of 5461 articles were presented. The trend topics in PN research are determined and it can be said that most of them related with intensive care units and cancer patients. This article may be a valuable resource for clinicians and scientists on PN global outcomes.

Keywords

• Parenteral nutrition
• Nutrition support
• Bibliometric analysis
• Trends

Kaynakça

1. 1. Zhao VM, Ziegler TR, Davis KA. 2020, Parenteral Nutrition. In: Davis K., Rosenbaum S. (eds) Surgical Metabolism. Springer, Cham. https://doi.org/10.1007/978-3-030-39781-4_13
2. 2. Weiss AJ, Fingar KR, Barrett ML, Elixhauser A, Steiner CA, Guenter P, et al. Characteristics of Hospital Stays Involving Malnutrition, 2013: Statistical Brief #210. 2016 Sep. In: Healthcare Cost and Utilization Project (HCUP) Statistical Briefs [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (US);2006 Feb–. PMID: 27854406.
3. 3. Pironi L, Boeykens K, Bozzetti F, Joly F, Klek S, et al. ESPEN guideline on home parenteral nutrition. Clin Nutr. 2020 Jun;39(6):1645-66. doi: 10.1016/j.clnu.2020.03.005. Epub 2020 Apr 18. PMID: 32359933.
4. 4. Braga M, Ljungqvist O, Soeters P, Fearon K, Weimann A, Bozzetti F; ESPEN. ESPEN Guidelines on Parenteral Nutrition: surgery. Clin Nutr. 2009 Aug;28(4):378-86. doi: 10.1016/j.clnu.2009.04.002. Epub 2009 May 21. PMID: 19464088.
5. 5. Seike J, Tangoku A, Yuasa Y, Okitsu H, Kawakami Y, Sumitomo M. The effect of nutritional support on the immune function in the acute postoperative period after esophageal cancer surgery: total parenteral nutrition versus enteral nutrition. J Med Invest. 2011 Feb;58(1-2):75-80. doi: 10.2152/jmi.58.75. PMID: 21372490.
6. 6. Hellerman Itzhaki M, Singer P. Advances in Medical Nutrition Therapy: Parenteral Nutrition. Nutrients. 2020 Mar 8;12(3):717. doi: 10.3390/nu12030717. PMID: 32182654; PMCID: PMC7146311.
7. 7. Elke G, van Zanten AR, Lemieux M, McCall M, Jeejeebhoy KN, Kott M, et al. Enteral versus parenteral nutrition in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials. Crit Care. 2016 Apr 29;20(1):117. doi: 10.1186/s13054-016-1298-1. PMID: 27129307; PMCID: PMC4851818.
8. 8. Weimann A, Braga M, Carli F, Higashiguchi T, Hübner M, Klek S, et al. ESPEN guideline: Clinical nutrition in surgery. Clin Nutr. 2017 Jun;36(3):623-50. doi: 10.1016/j.clnu.2017.02.013. Epub 2017 Mar 7. PMID: 28385477.

9. 9. Muslu Ü, Demir E. Development of Rhinoplasty: Yesterday and Today. Med Sci. 2019;23:294-301.
10. 10. Golpinar M, Demir E. Global research output of the cerebellum: Yesterday, today, and tomorrow. J of the Anato Soc of India. 2020;69(3);155-165.
11. 11. Zengin M, Baldemir R. Investigation of the global outcomes of acute respiratory distress syndrome with the effect of COVID-19 in publications: a bibliometric analysis between 1980 and 2020. Kırıkkale Uni Med J. 2021;23(2):279-92.
12. 12. Kiraz S, Demir E. Global Scientific Outputs of Schizophrenia Publications From 1975 to 2020: a Bibliometric Analysis. Psychiatr Q. 2021 Dec;92(4):1725-44. doi: 10.1007/s11126-021-09937-4. Epub 2021 Aug 3. PMID: 34341886.
13. 13. Doğan G, Karaca O. Análise bibliométrica no campo da anestesiologia no período de 2009‐2018 [A bibliometric analysis of the field of anesthesia during 2009-2018]. Braz J Anesthesiol. 2020 Mar-Apr;70(2):140-52. Portuguese. doi: 10.1016/j.bjan.2020.02.003. Epub 2020 May 22. PMID: 32499046.
14. 14. Veraar C, Geilen J, Fischer A, Sulz I, Tarantino S, Mouhieddine M, et al. Timing of parenteral nutrition in ICU patients: A transatlantic controversy. Clin Nutr ESPEN. 2021 Dec;46:532-8. doi: 10.1016/j.clnesp.2021.08.007. Epub 2021 Sep 9. PMID: 34857246.
15. 15. van Eck NJ, Waltman L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics. 2010 Aug;84(2):523-38. doi: 10.1007/s11192-009-0146-3. Epub 2009 Dec 31. PMID: 20585380; PMCID: PMC2883932.
16. 16. The World Bank. Website https://data.worldbank.org/indicator/NY.GDP.MKTP.CD 2020;[accessed 1 July 2021]
17. 17. Alverdy JC, Aoys E, Moss GS. Total parenteral nutrition promotes bacterial translocation from the gut. Surgery. 1988 Aug;104(2):185-90. PMID: 3135625.
18. 18. Cavicchi M, Beau P, Crenn P, Degott C, Messing B. Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure. Ann Intern Med. 2000 Apr 4;132(7):525-32. doi: 10.7326/0003-4819-132-7-200004040-00003. PMID: 10744588.
19. 19. Dudrick SJ, Wilmore DW, Vars HM, Rhoads JE. Long-term total parenteral nutrition with growth, development, and positive nitrogen balance. Surgery. 1968 Jul;64(1):134-42. PMID: 4968812.
20. 20. Jeejeebhoy KN, Langer B, Tsallas G, Chu RC, Kuksis A, Anderson GH. Total parenteral nutrition at home: studies in patients surviving 4 months to 5 years. Gastroenterology. 1976 Dec;71(6):943-53. PMID: 825411.
21. 21. Koletzko B, Goulet O, Hunt J, Krohn K, Shamir R; Parenteral Nutrition Guidelines Working Group; European Society for Clinical Nutrition and Metabolism; European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN); European Society of Paediatric Research (ESPR). 1. Guidelines on Paediatric Parenteral Nutrition of ESPGHAN and ESPEN. J Pediatr Gastroenterol Nutr. 2005 Nov;41 Suppl 2:S1-87. doi: 10.1097/01.mpg.0000181841.07090.f4. PMID: 16254497.
22. 22. Kudsk KA, Croce MA, Fabian TC, Minard G, Tolley EA, Poret HA, et al. Enteral versus parenteral feeding. Effects on septic morbidity after blunt and penetrating abdominal trauma. Ann Surg. 1992 May;215(5):503-11; discussion 511-3. doi: 10.1097/00000658-199205000-00013. PMID: 1616387; PMCID: PMC1242485.
23. 23. Mirtallo J, Canada T, Johnson D, Kumpf V, Petersen C, Sacks G, et al. Task Force for the Revision of Safe Practices for Parenteral Nutrition. Safe practices for parenteral nutrition. JPEN J Parenter Enteral Nutr. 2004 Nov-Dec;28(6):S39-70. doi: 10.1177/0148607104028006s39. Erratum in: JPEN J Parenter Enteral Nutr. 2006 Mar-Apr;30(2):177. PMID: 15568296.
24. 24. Moore FA, Feliciano DV, Andrassy RJ, McArdle AH, Booth FV, Morgenstein-Wagner TB, et al. Early enteral feeding, compared with parenteral, reduces postoperative septic complications. The results of a meta-analysis. Ann Surg. 1992 Aug;216(2):172-83. doi: 10.1097/00000658-199208000-00008. PMID: 1386982; PMCID: PMC1242589.
25. 25. Sheldon GF, Peterson SR, Sanders R. Hepatic dysfunction during hyperalimentation. Arch Surg. 1978 Apr;113(4):504-8. doi: 10.1001/archsurg.1978.01370160162028. PMID: 416812.
26. 26. Singer P, Berger MM, Van den Berghe G, Biolo G, Calder P, Forbes A, et al, ESPEN. ESPEN Guidelines on Parenteral Nutrition: intensive care. Clin Nutr. 2009 Aug;28(4):387-400. doi: 10.1016/j.clnu.2009.04.024. Epub 2009 Jun 7. PMID: 19505748.
27. 27. Staun M, Pironi L, Bozzetti F, Baxter J, Forbes A, Joly F, et al. ESPEN Guidelines on Parenteral Nutrition: home parenteral nutrition (HPN) in adult patients. Clin Nutr. 2009 Aug;28(4):467-79. doi: 10.1016/j.clnu.2009.04.001. Epub 2009 May 22. PMID: 19464089.
28. 28. Casaer MP, Mesotten D, Hermans G, Wouters PJ, Schetz M, Meyfroidt G, et al. Early versus late parenteral nutrition in critically ill adults. N Engl J Med. 2011 Aug 11;365(6):506-17. doi: 10.1056/NEJMoa1102662. Epub 2011 Jun 29. PMID: 21714640.
29. 29. Veterans Affairs Total Parenteral Nutrition Cooperative Study Group. Perioperative total parenteral nutrition in surgical patients. N Engl J Med. 1991 Aug 22;325(8):525-32. doi: 10.1056/NEJM199108223250801. PMID: 1906987.
30. 30. Ziegler TR, Young LS, Benfell K, Scheltinga M, Hortos K, Bye R, et al. Clinical and metabolic efficacy of glutamine-supplemented parenteral nutrition after bone marrow transplantation. A randomized, double-blind, controlled study. Ann Intern Med. 1992 May 15;116(10):821-8. doi: 10.7326/0003-4819-116-10-821. PMID: 1567096.
31. 31. Heidegger CP, Berger MM, Graf S, Zingg W, Darmon P, Costanza MC, et al. Optimisation of energy provision with supplemental parenteral nutrition in critically ill patients: a randomised controlled clinical trial. Lancet. 2013 Feb 2;381(9864):385-93. doi: 10.1016/S0140-6736(12)61351-8. Epub 2012 Dec 3. PMID: 23218813.
32. 32. Fivez T, Kerklaan D, Mesotten D, Verbruggen S, Wouters PJ, Vanhorebeek I, et al. Early versus Late Parenteral Nutrition in Critically Ill Children. N Engl J Med. 2016 Mar 24;374(12):1111-22. doi: 10.1056/NEJMoa1514762. Epub 2016 Mar 15. PMID: 26975590.
33. 33. Doig GS, Simpson F, Sweetman EA, Finfer SR, Cooper DJ, Heighes PT, et al; Early PN Investigators of the ANZICS Clinical Trials Group. Early parenteral nutrition in critically ill patients with short-term relative contraindications to early enteral nutrition: a randomized controlled trial. JAMA. 2013 May 22;309(20):2130-8. doi: 10.1001/jama.2013.5124. PMID: 23689848.