Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia associated with bronchiectasis: A rare case

Yıl 2019, , 528 - 529, 29.07.2019

İsmail Ağababaoğlu , Bülent Koçer , Filiz Banu Çetinkaya Ethemoğlu

https://doi.org/10.28982/josam.536031

Öz

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia is the precursor neuroendocrine tumor proliferations comprising extended focal extraluminal nodules in whole lung occasionally or limited to the bronchial or bronchiolar walls. A 30-year old patient who underwent lower left lobectomy due to the extended saccular bronchiectasis was presented. Histopathological examination of the surgical specimen revealed diffuse idiopathic pulmonary neuroendocrine cell hyperplasia associated with bronchiectasis.

Anahtar Kelimeler

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia, Bronchiectasis, Surgery

Bronşektazi zemininde gelişen diffüz idiyopatik pulmoner nöroendokrin hücre hiperplazisi: Nadir rastlanan bir olgu

Öz

Nöroendokrin hücre hiperplazisi çoğunlukla havayolu mukozasında bazal membranı penetre etmeyecek şekilde ortaya çıkan nadiren tüm akciğerde yaygın odaksal ekstralüminal nodül oluşturan nöroendokrin tümör öncülü proliferasyonlardır. Bu çalışmada 30 yaşında, genişletilmiş sakküler bronşektazi nedeniyle opere edilen ve cerrahi spesmenin histopatolojik değerlendirmesinde ek olarak diffüz idiyopatik pulmoner nöroendokrin hücre hiperplazisi saptanan olgu sunuldu.

Anahtar Kelimeler

Diffüz idiyopatik pulmoner nöroendokrin hücre hiperplazisi, Bronşektazi, Cerrahi

Kaynakça

• 1. Travis W, Brambilla E, Muller-Hermelink H, Harris CC, eds. Pathology and genetics: tumors of the lung, pleura, thymus and heart. World Health Organization classification of tumors. Lyon, France: IARC, 2004. doi: 10.1097/JTO.0000000000000630.
• 2. Dewan M, Malatani TS, Osinowo O, Al-Nour M, Zahrani ME. Lessons to be learned: a case study approach carsinoid tumorlets associated with diffuse bronchiectasis and intralobar sequestration. J R Soc Promot Health. 2000;120(2):192-5. doi: 10.1177/146642400012000310
• 3. Erbey A, Karadağ N, Ulutaş H, Kuzucu A, Soysal Ö. Multifocal tumorlets and a carcinoid tumor associated with bronchiectasis. Journal of Clinical and Experimental Investigations. 2012;3(2):273-6. doi: 10.5799/ahinjs.01.2012.02.0159
• 4. Garcia-Yuste M, Matilla JM, Alvarez-Gago T, Spanish Multicenter Study of Neuroendocrine Tumors of the Lung of the Spanish Society of Pneumonology and Thoracic Surgery (EMETNE-SEPAR). Prognostic factors in neuroendocrine lung tumors: a Spanish Multicenter Study. Ann Thorac Surg. 2000;70(2):258-63.
• 5. Cardillo G, Sera F, Di Martino M, Graziano P, Giunti R, Carbone L et al. Bronchial carcinoid tumors: nodal status and long-term survival after resection. Ann Thorac Surg. 2004;77(12):1781-5. doi :10.1016/j.athoracsur.2003.10.089
• 6. Kerr KM. Pulmonary preinvasive neoplasia. J Clin Pathol 2001;54(2):257-71.
• 7. Demirağ F, Altınok T. Pulmonary and peribronchial lymph node tumorlets: report of a case and review of the literature. Tumori. 2003;89(4):455-7.
• 8. D’Agati VD, Perzin KH. Carcinoid tumorlets of the lung with metastasis to a peribronchial lymph node: Report of a case and review of the literature. Cancer. 1985;55(12):2472-6.