Allopurinol nedenli toksik epidermal nekrolizin yüksek doz kortikosteroidler ve intravenöz immünoglobulinler ile tedavisi

Yıl 2019, , 530 - 532, 29.07.2019

Zeynep Gizem Kaya İslamoğlu , Mehmet Akyürek

https://doi.org/10.28982/josam.540023

Öz

Toksik epidermal nekroliz (TEN), ilaçlar, enfeksiyonlar ve maligniteler tarafından tetiklenen nadir, akut ve ciddi bir advers reaksiyondur. İlaçlar hastalığın ana nedenidir. En yaygın ilaçlar sulfonamidler ve penisilinlerdir ve en sık ilişkili bulaşıcı ajan herpes simplex virüsüdür. Allopurinol, gutta serum düşürücü tedavi için ilk sıra ilaçtır ve ABD Gıda ve İlaç İdaresi (FDA) tarafından onaylanmaktadır. Son araştırmalarda, allopurinolün yaşamı tehdit edici ilaç reaksiyonlarına neden olan en yaygın ilişkili ilaç olduğu bulundu. Burada, allopurinolün neden olduğu nadir bir TEN vakası, TEN'in tedavisinde intravenöz immünoglobulinlerin kullanımı (IVIg) ve yüksek doz sistemik kortikosteroidlerin etkinliğini/zararlarını sunmayı amaçladık.

Anahtar Kelimeler

Toksik epidermal nekroliz, SCORTEN, Allopurinol, IVIg, Metilprednizolon

Treatment of allopurinol-induced toxic epidermal necrolysis with high dose corticosteroids and intravenous immunoglobulins

Öz

Toxic epidermal necrolysis (TEN) is an uncommon, acute and severe adverse reaction triggered by drugs, infections and malignancies. Drugs are the main cause of the disease. The most common drugs are sulfonamides and penicillins and the most often associated infectious agent is herpes simplex virus. Allopurinol is the first line drug for serum lowering therapy in gout and is approved by the US Food and Drug Administration (FDA). In recent studies, allopurinol was found to be the most commonly associated drug causing life-threatening drug reactions. Here, we aimed to present a rare case of TEN induced by allopurinol, the efficacy/harm of high dose systemic corticosteroids and use of intravenous immunoglobulins (IVIg) in the treatment of TEN

Anahtar Kelimeler

Toxic epidermal necrolysis, SCORTEN, Allopurinol, IVIg, Methylprednisolone

Kaynakça

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