The relationship between zinc and hepatic steatosis

Öz

Nonalcoholic fatty liver disease (NAFLD) is the most commonly diagnosed liver disease in the recent years, with a prevalence of 15-20% among normal population. Liver steatosis is also a complication of obesity and affects 22-52% of obese children. In this aspect, it is an important public health problem. Increases in the amount of fatty acids entering the liver, increase in fatty acid synthesis and disorders in its secretion are included in its pathogenesis. The relationship between zinc, which is the second most abundant trace element found in the body after iron and necessary for many enzymes to function properly, and fatty liver disease has been shown in previous studies. The aim of this review is to discuss the relationship between zinc and liver steatosis in the light of current studies and contribute to the literature.

Anahtar Kelimeler

• Zinc,Trace element,Hepatic steatosis

Çinko ve hepatik steatoz arasındaki ilişki

Öz

Non-alkolik yağlı karaciğer hastalığı (NAFLD), prevalansı normal popülasyonda %15-20’lere ulaşan, son yıllarda en sık görülen karaciğer hastalığıdır. Karaciğer yağlanması, obezitenin bir komplikasyonu olarak da karşımıza çıkmakta ve obez çocukların %22-52’ini etkilemektedir. Bu yönüyle önemli bir halk sağlığı sorunudur. Karaciğere gelen yağ asid miktarında artış, yağ asidi sentezinin artışı ve sekresyonundaki bozukluklar, karaciğer yağlanmasının patogenezindeki mekanizmalardan bazılarıdır. Ayrıca, vücutta demirden sonra en bol bulunan ikinci eser element olan ve pek çok enzimin fonksiyon göstermesi için gerekli olan çinko ile karaciğer yağlanması arasında bir ilişki olduğu yapılan çalışmalarda gösterilmiştir. Bu derlemeyi hazırlamaktaki amacımız, vücuttaki çinko miktarının karaciğer yağlanması ile ilişkisini açıklamak ve güncel araştırma sonuçlarını içeren bir veri hazır¬lamaktır. Bu yönüyle çalışmamızın literatüre katkı sağlayacağı kanaatindeyiz.

Anahtar Kelimeler

• Çinko,Eser element,Hepatik steatoz

Kaynakça

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