Kırmızı kan hücresi dağılım genişliği (RDW) ülseratif kolit hastalarında klinik ve endoskopik aktiviteyi tahmin edebilir mi?

Öz

Amaç: Ülseratif kolitin (ÜK) hastalık aktivitesi ve şiddetine göre sınıflandırılması klinik uygulamada önemlidir, çünkü hastanın yönetimini belirler. Bu çalışmada, ÜK hastalarında kırmızı kan hücresi dağılım genişliği (RDW) ile klinik aktivite indeksi (KAİ) ve mukozal hastalığa göre hastalık şiddetini belirleyen endoskopik aktivite indeksleri (EAİ) arasındaki ilişkiyi araştırmayı amaçladık.
Yöntemler: Araştırma bir vaka kontrol çalışması olarak planlandı. ÜK tanısı alan 99 hasta klinik ve endoskopik aktivitelerine göre aktif hastalık grubu ve remisyon grubu olmak üzere iki gruba ayrıldı. Kolonoskopi yapılan ve normal bulunan 56 kişiden yaş ve cinsiyet uyumlu kontrol grupları oluşturuldu.
Bulgular: Serum RDW düzeyleri ÜK grubunda anlamlı olarak yüksekti (P<0,001). RDW ile yapılan post-hoc karşılaştırmalarda, kontrol grubu ile aktif hastalık grupları arasında istatistiksel olarak anlamlı farklılıklar gözlenmiştir (P<0,001). Bununla birlikte, RDW değerleri klinik ve endoskopik aktivitenin belirlenmesinde, aktif hastalık ve remisyon grupları arasında anlamlı değildi (sırasıyla P=0,05 ve P=0,09). Klinik ve endoskopik aktivite indekslerini tahmin ederken, RDW'nin cut-off değerleri sırasıyla 14,25 (%66 duyarlılık ve %72 özgüllük) ve 13,75 (%64 duyarlılık ve %62 özgüllük) idi.
Sonuç: Bu çalışma, RDW'nin ülseratif kolitte hastalık aktivitesi için bir belirteç olarak kullanılabileceğini gösterdi, ancak remisyon ve aktif hastalık ayrımında aynı etkinliği göstermedi.

Anahtar Kelimeler

• Ülseratif kolit,RDW,Endoskopik aktivite indeksi,Klinik aktivite indeksi

Can red blood cell distribution width (RDW) predict clinical and endoscopic activity in ulcerative colitis patients?

Abstract

Aim: Classification of ulcerative colitis (UC) according to disease activity and severity is important in clinical practice for it determines the management of the patient. In this study, we aimed to investigate the relationship between red blood cell distribution width (RDW) and clinical activity index (CAI) in UC patients as well as endoscopic activity indexes (EIA) that determine disease severity relative to mucosal disease.
Methods: This research was planned as a case-control study. Ninety-nine patients diagnosed with UC were divided an active disease group and a remission group according to their clinical and endoscopic findings. Age and gender-matched control groups were formed from 56 individuals with normal colonoscopic findings.
Results: Serum RDW levels were significantly higher in the UC group (P<0.001). In post-hoc comparisons, a statistically significant difference was observed between the control group and active disease groups (P<0.001). However, RDW values did not significantly predict clinical and endoscopic activity in either the active disease or the remission groups (P=0.05 and P=0.09, respectively). In predicting clinical and endoscopic activity indices, the cut-off values of RDW were 14.25 (66% sensitivity and 72% specificity) and 13.75 (64% sensitivity and 62% specificity), respectively.
Conclusion: This study showed that RDW can be used as a marker for disease activity in ulcerative colitis, but it did not show the same efficacy in remission and active disease distinction.

Keywords

• Ulcerative colitis,Endoscopic activity indexes,Clinical activity index,RDW

Kaynakça

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