Hematolojik enflamasyon belirteçleri erken gebelik kaybının göstergesi olabilir mi?

Öz

Amaç: İnsan gebeliklerinin yaklaşık % 50'sinde gebelik kaybı meydana gelmektedir ve erken gebeliğin en sık görülen komplikasyonudur. Bu çalışmanın amacı, erken gebelik kaybı ile inflamasyon arasındaki ilişkiyi hematolojik belirteçler ile değerlendirmektir. Yöntemler: Çalışma Ocak 2016 / Mart 2019 tarihleri arasında kliniğimizde gerçekleşmiş olan erken gebelik kaybı olgularını değerlendiren, olgu-kontrol çalışmasıdır. Erken gebelik kaybı grubu 94 hasta, kontrol grubu ise 104 miadında doğum yapmış kadından oluşturuldu. Grupların demografik verilerine ve tam kan sayımı sonuçlarına hasta dosyaları ve hastane bilgi yönetim sistemi taranarak ulaşıldı. Bulgular: İki grup arasında yaş ve vücut kitle indeksi açısından istatistiksel olarak anlamlı bir fark yoktu. Abortus grubunda gebelik kayıpları ortalama 9,03 (3,62) haftada gerçekleşmiştir. Abortus grubunda kontrol grubuna kıyasla platelet sayısı (P=0,003), NLR (P=0,036), PLR (P=0,032) ve plateletkrit (P=0,007) yüksek olarak saptanmıştır. Diğer taraftan, LMR (P=0,034) abortus grubunda düşük olarak saptanmıştır. Sonuçlar: Hematolojik enflamasyon parametreleri kolay ulaşılabilen ve maliyet olarak ucuz tetkiklerdir. Çalışmamızda bu parametrelerin erken gebelik kaybını öngörme başarısı değerlendirilmiş ve sonuç olarak, gruplar arasında hematolojik inflamasyon belirteçlerinde anlamlı farklılıklar olmasına rağmen, bu belirteçlerin duyarlılık ve özgüllüğünün düşük olduğu bulunmuştur.

Anahtar Kelimeler

• Erken gebelik kaybı
• Enflamasyon
• Hematolojik belirteçler

Can hematologic inflammation markers be the indicator of early pregnancy loss?

Abstract

Aim: Pregnancy loss occurs in 50% of human pregnancies and is the most common complication of early pregnancy. The aim of this study is to evaluate the relationship between early pregnancy loss and inflammation with hematological markers. Methods: This case-control study was carried out between January 2016-March 2019 in our clinic to evaluate the cases of early pregnancy loss. The early pregnancy loss group consisted of 94 patients, while the control group consisted of 104 women giving normal birth. Demographic data and complete blood count results of the groups were obtained from the patient files and hospital information management systems. Results: There were no statistically significant differences in terms of age and body mass index between the two groups. Pregnancy losses in the abortion group occurred at an average of 9.03 (3.62) weeks. In the abortus group, platelet count (P=0.003), NLR (P=0.036), PLR (P=0.032) and plateletcrit (P=0.007) were higher, while LMR (P=0.034) was lower, compared to the control group. Conclusions: Hematological inflammation parameters are easy to perform and cost-effective examinations. In our study, the success of these parameters to predict early pregnancy loss was evaluated, and it was found that although there are significant differences in hematological inflammation markers between the groups, the sensitivity and specificity of these markers are low.

Keywords

• Early pregnancy loss
• Inflammation
• Hematologic markers

Kaynakça

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