The role of serum cystatin C level in detection of early onset kidney injury after coronary artery bypass surgery

Yıl 2020, , 562 - 566, 01.07.2020

Mehmet Tercan , Gülçin Patmano , Tuğba Bingöl , Ahmet Kaya , Tulin Yazici

https://doi.org/10.28982/josam.758803

Öz

Aim: Acute kidney injury (AKI) is an important condition after coronary artery bypass graft (CABG) surgery. Precautions can be taken to prevent AKI by recognizing the risky patients in the preoperative period. In this study, we investigated the relationship between the serum cystatin C (CyC) levels and AKI after CABG surgery.
Methods: A total of 42 patients (mean age 59.33 (6.66) and 69% male) who underwent isolated on-pump CABG between June 2018 and January 2019 were included in this prospective cohort study. Creatinine and CyC levels were evaluated at the preoperative period, postoperative 2nd and 24th hours. Patients were assessed for the development of AKI according to the Acute Kidney Injury Network criteria and divided into two groups as those with and without AKI in the postoperative period.
Results: Based on the creatinine level at the postoperative 24th hour, 9 (21.4%) patients developed AKI. Compared to patients who did not develop AKI, it was found that CyC level was significantly higher at the postoperative 2nd hour in patients who developed AKI (1.06 (0.26) vs 0.87 (0.19), P=0.023). In patients who developed AKI, the duration of cross-clamp was significantly longer (P=0.038), and erythrocyte suspension (P<0.001) and the number of fresh frozen plasma infusions (P<0.001) were significantly higher.
Conclusion: Increased CyC levels were associated with the development of AKI in the early postoperative period. CyC measurements performed in the initial period after CABG can be used in the diagnosis of cardiac surgery related AKI.

Anahtar Kelimeler

Coronary artery bypass graft surgery, Serum cystatin C, Acute kidney injury

Koroner arter baypas cerrahisi sonrası erken dönemde gelişen böbrek hasarının saptanmasında serum sistatin C düzeyinin rolü

Öz

Amaç: Akut böbrek hasarı (AKI), koroner arter baypas greft (KABG) ameliyatından sonra gelişebilen önemli bir klinik durumdur. Preoperatif dönemde riskli hastaları tanıyarak AKI'nın önlenmesi için önlemler alınabilir. Bu nedenle, AKI için risk faktörlerini belirlemek çok önemlidir. Bu çalışmada, serum sistatin C (CyC) düzeyleri ile CABG cerrahisi sonrası gelişen AKI arasındaki ilişkiyi araştırdık.
Yöntemler: Haziran 2018-Ocak 2019 tarihleri arasında kardiyopulmoner bypass eşliğinde yapılan KABG cerrahisi yapılan toplam 42 hasta (ortalama yaş 59,33 (6,66) ve %69 erkek) bu prospektif kohort çalışmasına dahil edildi. Acut Kidney İnjury Network (AKİN) kriterlerine göre AKI gelişimi değerlendirildi. Hastalar postoperatif dönemde AKI olan ve olmayanlar olmak üzere iki gruba ayrıldı.
Bulgular: Postoperatif 24. saatte kreatinin düzeyine göre 9 (%21,4) hastada AKI gelişti. AKI gelişmeyen hastalarla karşılaştırıldığında, AKI gelişen hastalarda postoperatif 2. saatte CyC düzeyinin kreatinin düzeyine göre anlamlı derecede yüksek olduğu bulundu (1,06 (0,26) vs 0,87 (0,19), P=0,023). AKI gelişen hastalarda krosklemp süresi anlamlı olarak daha uzun (P=0,038), eritrosit süspansiyonu (P<0,001) ve taze donmuş plazma (P<0,001) kullanımı AKI gelişmeyen hastalardan anlamlı olarak daha yüksekti.
Sonuç: Artmış CyC düzeyleri, postoperatif erken dönemde AKI gelişimi ile ilişkili bulunmuştur. CABG sonrası erken dönemde yapılan CyC ölçümleri, kalp cerrahisi ile ilişkili AKI tanısında kullanılabilir.

Anahtar Kelimeler

Koroner arter baypas greft cerrahisi, Serum sistatin C, Akut böbrek hasarı

Kaynakça

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