Larenksin Primer T Hücreli Non-Hodgkin Lenfoması: Vaka Sunumu

Öz

Lenfoma, lenfatik hücrelerden kaynaklanan malign bir hastalıktır. Hodgkin ve non-Hodgkin lenfoma olmak üzere iki ana gruba ayrılmasına ragmen birçok alt tipi vardır. Primer larengeal non-Hodgkin lenfoma, tüm larengeal tümörlerin %1’inden azını oluşturur. Bu vaka sunumunda larengeal kitle nedeni ile yutma güçlüğü çeken 43 yaşındaki erkek hasta sunulmuştur. Bu hastada morfoloji ve immünohistokimyasal yöntemlerle yapılan histopatolojik incelemede Dünya Sağlık Örgütü sınıflandırmasına göre T hücreli lenfoma ortaya çıkmıştır. Bunun üzerine hasta kemo-radyoterapiye yönlendirildi.

Anahtar Kelimeler

• larenks
• lenfoma
• T hücreli

Primary T-cell non-Hodgkin's lymphoma of the larynx: A case report

Abstract

Lymphoma is a malignant disease of lymphatic cells. Despite numerous sub-types, the disease is generally divided into two main groups: Hodgkin and non-Hodgkin lymphoma. Primary laryngeal non-Hodgkin lymphoma accounts for less than 1% of all laryngeal tumors. We herein present a 43-year-old male patient with difficulty swallowing due to a laryngeal mass. Morphological and immunohistochemical examination revealed T cell lymphoma according to the World Health Organization classification. The patient was referred for chemo-radiotherapy. Primary lymphoma of the larynx is a rare, and primary T-cell laryngeal lymphoma is an even rarer tumor.

Keywords

• Larynx
• Lymphoma
• Non-Hodgkin
• T-cell

Kaynakça

1. 1. Zhao P, Zhou Y, Li J. Primary Laryngeal Lymphoma in China: A Retrospective Study of the Last 25 Years. J Laryngol Otol. 2019;19:1-4. doi: 10.1017/S0022215119001622.
2. 2. Scott AH, Bobby AT, Sunah C, Inna AH. Epidemiology and Prognostic Indicators in Laryngeal Lymphoma: A Population-Based Analysis. Laryngoscope. 2018;128(9):2044-9. doi: 10.1002/lary.27074.
3. 3. Siddiqui NA, Branstetter BF, Hamilton BE, Ginsberg LE, Glastonbury CM, Harnsberger HR et al. Imaging characteristics of primary laryngeal lymphoma. AJNR Am J Neuroradiol. 2010;31(7):1261-5. doi: 10.3174/ajnr.A2085.
4. 4. Kim KH, Kim RB, Woo SH. Individual participant data meta-analysis of primary laryngeal lymphoma: focusing on the clinical characteristics and prognosis. Laryngoscope. 2015;125(10):2741–8. doi: 10.1002/lary.25391.
5. 5. Junior NT, Zago TM, Pauna HF, Crespo AN. Non-Hodgkin lymphoma in supraglottis: case report. Otolaryngol (Sunnyvale). 2017;7:285. doi: 10.4172/2161-119X.1000285
6. 6. Picard A, Cardinne C, Denoux Y, Wagner I, Chabolle F, Bach C-A. Extranodal lymphoma of the head and neck: a 67-case series. Eur Ann Otorhinolaryngol Head Neck Dis. 2015;132(2):71–5. doi: 10.1016/j.anorl.2014.07.005
7. 7. Quimby AE, Caulley L, Rodin D, Purgina B, Eapen L, Shier L, et al. Primary Burkitt lymphoma of the supraglottic larynx: a case report and review of the literature. J Med Case Rep. 2017;11(1):65. doi: 10.1186/s13256-017-1209-3.
8. 8. Ishak A, Mat Saad A, Wan Sulaiman W, Husin A, Halim A. Anterior chest wall reconstruction for cutaneous involvement of Hodgkin’s lymphoma. J Surg Med. 2019;3(12):888-90. doi: 10.28982/josam.592917.

9. 9. Vega F, Lin P, Medeiros LJ. Extranodal lymphomas of the head and neck. Ann Diagn Pathol. 2005;9(6):340–50. doi: 10.1016/j.anndiagpath.2005.09.020.
10. 10. Smith MS, Browne JD, Teot LA. A case of primary laryngeal T-cell lymphoma in a patient with acquired immunodeficiency syndrome. Am J Otolaryngol. 1996;17(5):332-4. doi: 10.1016/s0196-0709(96)90020-4
11. 11. Tardio JC, Moreno A, Perez C, Hernandez-Rivas JA, Lopez-Carreira M. Primary laryngeal T/NK-cell lymphoma, nasal-type: an unusual location for an aggressive subtype of extranodal lymphoma. Eur Arch Otorhinolaryngol. 2008;265(6):705–8. doi: 10.1007/s00405-007-0497-4.
12. 12. Yilmaz M, Ibrahimov M, Mamanov M, Rasidov R, Oktem F. Primary marginal zone B-cell lymphoma of the larynx. J Craniofac Surg. 2012;23(1):1-2. doi: 10.1097/SCS.0b013e318242055a
13. 13. Paleri V, Stafford FW, Sammut MS. Laser debulking in malignant upper airway obstruction. Head Neck. 2005;27(4):296-301. doi: 10.1002/hed.20153.