Oral Beslenme Desteğinin Kanser Tedavisi Gören Çocuklarda Vücut Kitle İndeksi Üzerindeki Etkisi

Öz

Amaç: Kötü beslenme, kanserli çocuklarda kemoterapi ve radyoterapi gibi tedavi yöntemlerinin toleransı etkileyebilen tehlikeli bir komorbiditedir. Aynı zamanda tedavi sonucunu ve genel sağkalımı da olumsuz etkilemektedir. Bu çalışmanın amacı, kanser tedavisi gören yetersiz beslenen çocuklarda oral beslenme desteğinin vücut kitle indeksi (VKİ) üzerindeki etkisini değerlendirmektir. Yöntemler: Bu çalışma tek merkezli retrospektif bir çalışma olup, çalışmaya dahil edilen malnütriye pediatrik kanser hastaların kayıtları Kocaeli Üniversitesi Tıp Fakültesi, Pediatrik Onkoloji Bölümü (Kocaeli, Türkiye)'nden toplanılmıştır ve analiz edilmiştir. Spesifik anti-kanser rejimlerine ek olarak oral nütrisyonel destek (OND) alan hastaların beslenme durumları takip ziyaretlerinde ölçülen kilo, boy ve VKİ'ye göre 8 aylık bir süre boyunca değerlendirilmiştir. Veriler, tüm hastalar için veya aşağıdaki tümör gruplarına kümelendikten sonra analiz edilmiştir; CNS tümörleri% 13.3 (8 hasta), lenfoma% 18.3 (11 hasta), diğer tümörler% 68.3 (41 hasta). Bulgular: Çalışmaya beslenme bozukluğu olan 60 pediatrik kanser hastası (% 64,6 erkek,% 35,4 kadın) dahil edilmiştir. OND öncesi ve OND sonrası antropometrik verilerin karşılaştırılması sonrası, 36 hastada (%60) VKİ'de artışa karşın 24 hastada (%40) VKİ'de azalma olduğu görülmüştür (p <0.05). Diğer tümör grubu (p <0.001) ve lenfoma grubu (p = 0.012) için de istatistiksel olarak anlamlı artış gözlenmiştir. Sonuç: OND, pediatrik kanser hastalarında VKİ'yi artıran ve beslenme durumunu iyileştiren önemli bir müdahaledir. İyileşmenin kapsamı muhtemelen hastalığın türü ve yeri ile ilgilidir.

Anahtar Kelimeler

• pediatri
• malnütrisyon
• kanser
• vücut kitle indeksi

The impact of oral nutritional supplementation in children treated for cancer

Abstract

Background/Aim: Malnutrition is a dangerous comorbidity in children with cancer that can affect tolerance to treatment modalities such as chemotherapy and radiotherapy. It also adversely affects the treatment outcome and overall survival. It has been known that low Z score of body mass index (BMI) indicates malnutrition. This study aims to underline the effects of oral nutritional supplementation (ONS) on pediatric oncology patients. Methods: All records were collected from Kocaeli University Hospital, Department of Pediatric Oncology, Kocaeli, Turkey, and analyzed. Weight, height, and BMI status of sixty patients who received ONS with cancer treatment were recorded during visits up to 8 months after the start of ONS. Statistical analyses were maintained on the whole cohort as well as on following tumor sub-groups: CNS tumors (13.3%), lymphoma (18.3%), other tumors (68.3%). Results: Sixty malnourished pediatric oncology patients (64.6% male, 35.4% female) were included in the study cohort. BMI values of the majority (60%, P<0.05) of patients increased after ONS treatment while those of 40% decreased. BMI values also increased in the case of other tumors and lymphoma sub-groups (P<0.001 and P=0.012, respectively). Conclusion: This study underlined the benefits of ONS treatment in terms of BMI status among pediatric oncology patients. The recovery rate of nutritional status depends on malignancy, cancer type and location.

Keywords

• pediatrics
• malnutrition
• cancer
• body mass index

Kaynakça

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