Evaluation of the relationship between polysomnography parameters, physical examination findings and oxidative stress parameters in patients with obstructive sleep apnea syndrome

Abstract

Background/Aim: Oxidative stress status in obstructive sleep apnea syndrome (OSAS) is well discussed in the literature. Oxidative stress levels increase, and antioxidant system activi-ty decreases in OSAS patients. However, the change in oxidative stress status in positional (pOSAS) and non-positional (npOSAS) OSAS has not been adequately examined. The aim of this study was to compare OSAS patients’ polysomnographic (PSG) parameters and oxidative stress capacities with the structural and functional properties of the upper respiratory tract. Methods: This study was designed as prospective case-control study and patients were divided into three groups as control, pOSAS and npOSAS according to their PSG findings. Ear nose throat examinations including rhinomanometry test and oxidative stress blood parameter tests were conducted to all patients. Variables among the groups were compared. Results: All PSG parameters were significantly worse in the OSAS groups than the control group (P<0.05). The mean AHIs of the pOSAS and npOSAS groups were 21.7 (16.5), and 31.2 (21.9), respectively. AHI, desaturation number and minimal SpO2 values of the pOSAS group were significantly lower compared to the npOSAS group (P=0.043, P=0.017 and P=0.006, respectively). TNF α was significantly lower and adiponectin was significantly higher in the pOSAS group compared to the npOSAS group (P=0.001, P<0.001 respectively). The two groups were similar in terms of rhinomanometry results (P=0.888). Conclusion: The lack of difference between pOSAS and npOSAS patients in terms of rhinomanometry results may indicate that the nose may not play a decisive role in the differentiation of these groups. Only OSAS severity may not be a determinant factor in oxidative stress balance in patients with pOSAS and np OSAS.

Keywords

• Obstructive sleep apnea
• Oxidative stress
• Rhinomanometry

Kaynakça

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