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The relationship between zinc and hepatic steatosis

Yıl 2019, Cilt: 3 Sayı: 8, 609 - 611, 01.08.2019

Okan Dikker Hüseyin Dağ Emine Türkkan Nevin Çetin Dağ Nafiye Emel Çakar

https://doi.org/10.28982/josam.608618

Öz

Nonalcoholic fatty liver disease (NAFLD) is the most commonly diagnosed liver disease in the recent years, with a prevalence of 15-20% among normal population. Liver steatosis is also a complication of obesity and affects 22-52% of obese children. In this aspect, it is an important public health problem. Increases in the amount of fatty acids entering the liver, increase in fatty acid synthesis and disorders in its secretion are included in its pathogenesis. The relationship between zinc, which is the second most abundant trace element found in the body after iron and necessary for many enzymes to function properly, and fatty liver disease has been shown in previous studies. The aim of this review is to discuss the relationship between zinc and liver steatosis in the light of current studies and contribute to the literature.

Anahtar Kelimeler

Zinc Trace element Hepatic steatosis

Kaynakça

  • 1. Cairns SR, Peters TJ. Biochemical analysis of hepatic lipid in alcoholic and diabetic and control subjects. Clin Sci. 1983;65:645–52.
  • 2. Burdette HL, Whitaker RC, Kahn RS. Association of maternal obesity and depressive symptoms with television-viewing time in low-income preschool children. Arch Pediatr Adolesc Med. 2003;157:894-9.
  • 3. Day CP, James OF. Steatohepatitis: a tale of two “hits”?, Gastroenterology. 1998;114:842-5.
  • 4. Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 2006;43:99-112.
  • 5. Sentürk Ö. Nonalkolik Yaglı Karaciger Hastalıgı (NAYKH). Folia. 2004;1:12-7.
  • 6. Wessels I, Maywald M, Rink L. Zinc as a gatekeeper of immune function. Nutrients. 2017;9:1286.
  • 7. Vallee BL, Falchuk KH. The biochemical basis of zinc physiology. Physiol Rev. 1993;73:79–118.
  • 8. Powell SR. The antioxidant properties of zinc. J Nutr. 2000;130:1447–54.
  • 9. Leoni G, Rosato A, Perozzi G. Zinc proteome interaction network as a model to identify nutrient-affected pathways in human pathologies. Genes Nutr. 2014;9:436.
  • 10. Roohani N, Hurrell R, Kelishadi R, Schulin R. Zinc and its importance for human health: Anintegrative review. J Res Med Sci. 2013;18(2):144-57.
  • 11. Mohammad KM, Zhou Z, Cave M, Barve A, Mc Clain CJ. Zinc and Liver Disease. Nutr Clin Pract. 2012;27(1):8-20.
  • 12. Shidfar F, Faghihi A, Amiri HL, Mousavi SN. Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats. Iran J Med Sci. 2018;43:26-31.
  • 13. Elias I, Franckhauser S, Ferre T, Vila L,Tafuro S, Munoz S, et al. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes. 2012;61:1801-13.
  • 14. Stamoulis I, Kouraklis G, Theocharis S. Zinc and the liver: an active interaction. Dig Dis Sci. 2007;52:1595-612.
  • 15. Kadhim HM, Ismail SH, Hussein KI, Bakir IH, Sahib AS, Khalaf BH, et al. Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin. J Pineal Res. 2006;41:189-93.
  • 16. Gaetke LM, Mc Clain CJ, Talwalkar RT, Shedlofsky SI. Effects of endotoxin on zinc metabolism in human volunteers. Am J Physiol. 1997;272:E952-6.
  • 17. Tarantino G, Savastano S, Colao A. Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance. World J Gastroenterol. 2010;16:4773–83.
  • 18. Afridi HI, Kazi TG, Kazi N, Baig JA, Jamali MK, Arain MB, et al. Status of essential trace metals in biological samples of diabetic mother and their neonates. Arch Gynecol Obstet. 2009;280:415–23.
  • 19. Viktorínová A, Tošerová E, Križko M, Ďuračková Z. Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus. Metabolism. 2009;58:1477–82.
  • 20. Farvid MS, Siassi F, Jalali M, Hosseini M, Saadat N. The impact of vitamin and/or mineral supplementation on lipid profiles in type 2 diabetes. Diabetes Res Clin Pract. 2004;65:21–8.
  • 21. Kelishadi R, Hashemipour M, Adeli K, Tavakoli N, Movahedian- Attar A, Shapouri J, et al. Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome. Metab Syndr Relat Disord. 2010;8:505–10.
  • 22. Nascimento Marreiro D, Fisberg M, Cozzolino SMF. Zinc nutritional status and its relationships with hyperinsulinemia in obese children and adolescents. Biol Trace Elem Res. 2004;100:137–49.
  • 23. Tungtrongchitr R, Pongpaew P, Phonrat B, Tungtrongchitr A, Viroonudomphol D, Vudhivai N, et al. Serum copper, zinc, ceruloplasmin and superoxide dismutase in Thai overweight and obese. J Med Assoc Thai. 2003;86:543–51.
  • 24. Rossner S. Childhood obesity and adulthood consequences. Acta Paediatr. 1998;87:1-5.
  • 25. Martorell R, Kettle K, Hughes ML, Grummer-Stawn ML. Overweight and obesity in preschool children from developing countries. Int J Obes Relat Metab Disord. 2000;24:959-67.
  • 26. Mousavi SN, Faghihi A, Motaghinejad M, Shiasi M, Imanparast F, Amiri HL, et al. Zinc and Selenium Co-supplementation Reduces Some Lipid Peroxidation and Angiogenesis Markers in a Rat Model of NAFLD-Fed High Fat Diet. Biol Trace Elem Res. 2018;181(2):288-95.
  • 27. Adams LA, Angulo P, Lindor KD. Nonalcoholic fatty liver disease. Can Med Assoc J. 2005;172:899–905.
  • 28. Uchiyama S, Shimizu T, Shirasawa T. Cu Zn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice. J Biol Chem. 2006;281:31713–9.
  • 29. Shaheen AA, el-Fattah AA. Effect of dietary zinc on lipid peroxidation, glutathione, protein thiols levels and superoxide dismutase activity in rat tissues. Int J Biochem Cell Biol. 1995;27:89–95.
  • 30. Ozturk A, Baltaci AK, Mogulkoc R, Oztekin E, Sivrikaya A, Kurtoglu E, et al. Effects of zinc deficiency and supplementation on malondialdehyde and glutathione levels in blood and tissues of rat performing swimming exercise. Biol Trace Elem. 2003;94:157–66.
  • 31. Himoto T, Nomura T, Tani J, Miyoshi H, Morishita A, Yoneyama H, et al. Exacerbation of Insulin Resistance and Hepatic Steatosis Deriving from Zinc Deficiency in Patients with HCV-Related Chronic Liver Disease. Biol Trace Elem Res. 2015;163:81–8.
  • 32. Mikhail TH, Nicola WG, Ibrahim KH, Salama SH, Emam M. Abnormal zinc and copper metabolism in hepatic steatosis. Boll Chim Farmaceuticol. 1996;135:591–7.
  • 33. Bode JC, Hanisch P, Henning H, Koenig W, Richter FW, Bode C. Hepatic zinc content in patients with various stages of alcoholic liver disease and in patients with chronic active and chronic persistent hepatitis. Hepatology. 1988;6:1605–9.
  • 34. Gimenez A, Pares A, Alie S, Camps J, Deulofeu R, Caballeria J, et al. Fibrogenetic and collagenolytic activity in carbontetrachloride-injured rats: beneficial effects of zinc administration. J Hepatol. 1994;21:292–8.
  • 35. Baltaci AK, Mogulkoc R, Salbacak A, Celik I, Sivrikaya A. The role of zinc supplementation in the inhibition of tissue damage caused by exposure to electoromagnetic field in rat lung and liver tissues. Bratisl Lek Listy. 2012;113:400–3.

Çinko ve hepatik steatoz arasındaki ilişki

Yıl 2019, Cilt: 3 Sayı: 8, 609 - 611, 01.08.2019

Okan Dikker Hüseyin Dağ Emine Türkkan Nevin Çetin Dağ Nafiye Emel Çakar

https://doi.org/10.28982/josam.608618

Öz

Non-alkolik yağlı karaciğer hastalığı (NAFLD), prevalansı normal popülasyonda %15-20’lere ulaşan, son yıllarda en sık görülen karaciğer hastalığıdır. Karaciğer yağlanması, obezitenin bir komplikasyonu olarak da karşımıza çıkmakta ve obez çocukların %22-52’ini etkilemektedir. Bu yönüyle önemli bir halk sağlığı sorunudur. Karaciğere gelen yağ asid miktarında artış, yağ asidi sentezinin artışı ve sekresyonundaki bozukluklar, karaciğer yağlanmasının patogenezindeki mekanizmalardan bazılarıdır. Ayrıca, vücutta demirden sonra en bol bulunan ikinci eser element olan ve pek çok enzimin fonksiyon göstermesi için gerekli olan çinko ile karaciğer yağlanması arasında bir ilişki olduğu yapılan çalışmalarda gösterilmiştir. Bu derlemeyi hazırlamaktaki amacımız, vücuttaki çinko miktarının karaciğer yağlanması ile ilişkisini açıklamak ve güncel araştırma sonuçlarını içeren bir veri hazır¬lamaktır. Bu yönüyle çalışmamızın literatüre katkı sağlayacağı kanaatindeyiz.

Anahtar Kelimeler

Çinko Eser element Hepatik steatoz

Kaynakça

  • 1. Cairns SR, Peters TJ. Biochemical analysis of hepatic lipid in alcoholic and diabetic and control subjects. Clin Sci. 1983;65:645–52.
  • 2. Burdette HL, Whitaker RC, Kahn RS. Association of maternal obesity and depressive symptoms with television-viewing time in low-income preschool children. Arch Pediatr Adolesc Med. 2003;157:894-9.
  • 3. Day CP, James OF. Steatohepatitis: a tale of two “hits”?, Gastroenterology. 1998;114:842-5.
  • 4. Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 2006;43:99-112.
  • 5. Sentürk Ö. Nonalkolik Yaglı Karaciger Hastalıgı (NAYKH). Folia. 2004;1:12-7.
  • 6. Wessels I, Maywald M, Rink L. Zinc as a gatekeeper of immune function. Nutrients. 2017;9:1286.
  • 7. Vallee BL, Falchuk KH. The biochemical basis of zinc physiology. Physiol Rev. 1993;73:79–118.
  • 8. Powell SR. The antioxidant properties of zinc. J Nutr. 2000;130:1447–54.
  • 9. Leoni G, Rosato A, Perozzi G. Zinc proteome interaction network as a model to identify nutrient-affected pathways in human pathologies. Genes Nutr. 2014;9:436.
  • 10. Roohani N, Hurrell R, Kelishadi R, Schulin R. Zinc and its importance for human health: Anintegrative review. J Res Med Sci. 2013;18(2):144-57.
  • 11. Mohammad KM, Zhou Z, Cave M, Barve A, Mc Clain CJ. Zinc and Liver Disease. Nutr Clin Pract. 2012;27(1):8-20.
  • 12. Shidfar F, Faghihi A, Amiri HL, Mousavi SN. Regression of Nonalcoholic Fatty Liver Disease with Zinc and Selenium Co-supplementation after Disease Progression in Rats. Iran J Med Sci. 2018;43:26-31.
  • 13. Elias I, Franckhauser S, Ferre T, Vila L,Tafuro S, Munoz S, et al. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes. 2012;61:1801-13.
  • 14. Stamoulis I, Kouraklis G, Theocharis S. Zinc and the liver: an active interaction. Dig Dis Sci. 2007;52:1595-612.
  • 15. Kadhim HM, Ismail SH, Hussein KI, Bakir IH, Sahib AS, Khalaf BH, et al. Effects of melatonin and zinc on lipid profile and renal function in type 2 diabetic patients poorly controlled with metformin. J Pineal Res. 2006;41:189-93.
  • 16. Gaetke LM, Mc Clain CJ, Talwalkar RT, Shedlofsky SI. Effects of endotoxin on zinc metabolism in human volunteers. Am J Physiol. 1997;272:E952-6.
  • 17. Tarantino G, Savastano S, Colao A. Hepatic steatosis, low-grade chronic inflammation and hormone/growth factor/adipokine imbalance. World J Gastroenterol. 2010;16:4773–83.
  • 18. Afridi HI, Kazi TG, Kazi N, Baig JA, Jamali MK, Arain MB, et al. Status of essential trace metals in biological samples of diabetic mother and their neonates. Arch Gynecol Obstet. 2009;280:415–23.
  • 19. Viktorínová A, Tošerová E, Križko M, Ďuračková Z. Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus. Metabolism. 2009;58:1477–82.
  • 20. Farvid MS, Siassi F, Jalali M, Hosseini M, Saadat N. The impact of vitamin and/or mineral supplementation on lipid profiles in type 2 diabetes. Diabetes Res Clin Pract. 2004;65:21–8.
  • 21. Kelishadi R, Hashemipour M, Adeli K, Tavakoli N, Movahedian- Attar A, Shapouri J, et al. Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome. Metab Syndr Relat Disord. 2010;8:505–10.
  • 22. Nascimento Marreiro D, Fisberg M, Cozzolino SMF. Zinc nutritional status and its relationships with hyperinsulinemia in obese children and adolescents. Biol Trace Elem Res. 2004;100:137–49.
  • 23. Tungtrongchitr R, Pongpaew P, Phonrat B, Tungtrongchitr A, Viroonudomphol D, Vudhivai N, et al. Serum copper, zinc, ceruloplasmin and superoxide dismutase in Thai overweight and obese. J Med Assoc Thai. 2003;86:543–51.
  • 24. Rossner S. Childhood obesity and adulthood consequences. Acta Paediatr. 1998;87:1-5.
  • 25. Martorell R, Kettle K, Hughes ML, Grummer-Stawn ML. Overweight and obesity in preschool children from developing countries. Int J Obes Relat Metab Disord. 2000;24:959-67.
  • 26. Mousavi SN, Faghihi A, Motaghinejad M, Shiasi M, Imanparast F, Amiri HL, et al. Zinc and Selenium Co-supplementation Reduces Some Lipid Peroxidation and Angiogenesis Markers in a Rat Model of NAFLD-Fed High Fat Diet. Biol Trace Elem Res. 2018;181(2):288-95.
  • 27. Adams LA, Angulo P, Lindor KD. Nonalcoholic fatty liver disease. Can Med Assoc J. 2005;172:899–905.
  • 28. Uchiyama S, Shimizu T, Shirasawa T. Cu Zn-SOD deficiency causes ApoB degradation and induces hepatic lipid accumulation by impaired lipoprotein secretion in mice. J Biol Chem. 2006;281:31713–9.
  • 29. Shaheen AA, el-Fattah AA. Effect of dietary zinc on lipid peroxidation, glutathione, protein thiols levels and superoxide dismutase activity in rat tissues. Int J Biochem Cell Biol. 1995;27:89–95.
  • 30. Ozturk A, Baltaci AK, Mogulkoc R, Oztekin E, Sivrikaya A, Kurtoglu E, et al. Effects of zinc deficiency and supplementation on malondialdehyde and glutathione levels in blood and tissues of rat performing swimming exercise. Biol Trace Elem. 2003;94:157–66.
  • 31. Himoto T, Nomura T, Tani J, Miyoshi H, Morishita A, Yoneyama H, et al. Exacerbation of Insulin Resistance and Hepatic Steatosis Deriving from Zinc Deficiency in Patients with HCV-Related Chronic Liver Disease. Biol Trace Elem Res. 2015;163:81–8.
  • 32. Mikhail TH, Nicola WG, Ibrahim KH, Salama SH, Emam M. Abnormal zinc and copper metabolism in hepatic steatosis. Boll Chim Farmaceuticol. 1996;135:591–7.
  • 33. Bode JC, Hanisch P, Henning H, Koenig W, Richter FW, Bode C. Hepatic zinc content in patients with various stages of alcoholic liver disease and in patients with chronic active and chronic persistent hepatitis. Hepatology. 1988;6:1605–9.
  • 34. Gimenez A, Pares A, Alie S, Camps J, Deulofeu R, Caballeria J, et al. Fibrogenetic and collagenolytic activity in carbontetrachloride-injured rats: beneficial effects of zinc administration. J Hepatol. 1994;21:292–8.
  • 35. Baltaci AK, Mogulkoc R, Salbacak A, Celik I, Sivrikaya A. The role of zinc supplementation in the inhibition of tissue damage caused by exposure to electoromagnetic field in rat lung and liver tissues. Bratisl Lek Listy. 2012;113:400–3.
Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Biyokimya ve Hücre Biyolojisi (Diğer)
Bölüm Derleme
Yazarlar

Okan Dikker 0000-0002-9153-6139

Hüseyin Dağ 0000-0001-7596-7687

Emine Türkkan Bu kişi benim 0000-0002-5126-7843

Nevin Çetin Dağ Bu kişi benim 0000-0002-9471-5650

Nafiye Emel Çakar Bu kişi benim 0000-0003-2036-4082

Yayımlanma Tarihi 1 Ağustos 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 3 Sayı: 8

Kaynak Göster

APA Dikker, O., Dağ, H., Türkkan, E., Çetin Dağ, N., vd. (2019). The relationship between zinc and hepatic steatosis. Journal of Surgery and Medicine, 3(8), 609-611. https://doi.org/10.28982/josam.608618
AMA Dikker O, Dağ H, Türkkan E, Çetin Dağ N, Çakar NE. The relationship between zinc and hepatic steatosis. J Surg Med. Ağustos 2019;3(8):609-611. doi:10.28982/josam.608618
Chicago Dikker, Okan, Hüseyin Dağ, Emine Türkkan, Nevin Çetin Dağ, ve Nafiye Emel Çakar. “The Relationship Between Zinc and Hepatic Steatosis”. Journal of Surgery and Medicine 3, sy. 8 (Ağustos 2019): 609-11. https://doi.org/10.28982/josam.608618.
EndNote Dikker O, Dağ H, Türkkan E, Çetin Dağ N, Çakar NE (01 Ağustos 2019) The relationship between zinc and hepatic steatosis. Journal of Surgery and Medicine 3 8 609–611.
IEEE O. Dikker, H. Dağ, E. Türkkan, N. Çetin Dağ, ve N. E. Çakar, “The relationship between zinc and hepatic steatosis”, J Surg Med, c. 3, sy. 8, ss. 609–611, 2019, doi: 10.28982/josam.608618.
ISNAD Dikker, Okan vd. “The Relationship Between Zinc and Hepatic Steatosis”. Journal of Surgery and Medicine 3/8 (Ağustos 2019), 609-611. https://doi.org/10.28982/josam.608618.
JAMA Dikker O, Dağ H, Türkkan E, Çetin Dağ N, Çakar NE. The relationship between zinc and hepatic steatosis. J Surg Med. 2019;3:609–611.
MLA Dikker, Okan vd. “The Relationship Between Zinc and Hepatic Steatosis”. Journal of Surgery and Medicine, c. 3, sy. 8, 2019, ss. 609-11, doi:10.28982/josam.608618.
Vancouver Dikker O, Dağ H, Türkkan E, Çetin Dağ N, Çakar NE. The relationship between zinc and hepatic steatosis. J Surg Med. 2019;3(8):609-11.
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