Araştırma Makalesi
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Effects of vitamin D treatment on the heart tissue and adropin levels in thyrotoxicosis rats

Yıl 2022, Cilt: 6 Sayı: 3, 382 - 385, 01.03.2022
https://doi.org/10.28982/josam.961385

Öz

Background/Aim: Thyrotoxicosis is a hypermetabolic disease, common in people with iodine deficiency. Cardiac pathologies can be seen in untreated cases. Vitamin D is a supportive therapy for thyrotoxicosis and its deficiency also plays an important role in pathologies including cardiac diseases. Adropin is a peptide hormone regulating the energy homeostasis, and its levels in blood change in cardiac pathologies. Our purpose is to reveal the effects of vitamin D treatment on the heart tissue of rats with thyrotoxicosis and on the adropin levels.
Methods: Our study was designed as 25 days. 28 Sprague-Dawley female rats were divided into 4 groups; Control (3ml of distilled water), Thyrotoxicosis (100μg/day L-thyroxine) Treatment (100μg/day L-thyroxine+200IU /day Vit. D), Vit D (200IU/day Vit. D). Firstly, heart tissues were stained with Masson trichrome method. The preparations were examined under the microscope and evaluated semi-quantitatively. After that, serum adropin levels were measured with ELISA method. Malondialdehyde level of heart tissue was evaluated by spectrophotometry. Heart tissue was evaluated in aspects of fibrosis, congestion, edema and impairment of tissue integrity.
Results: All of the evaluation parameters of the heart tissue were found highly significantly increased in thyrotoxicosis group, in contrast to the control and vitamin D group. Despite a decrease in the treatment group, there was no significant difference in the thyrotoxicosis group (P<0.001). Serum adropin levels of all groups were found to be decreased in contrast to the thyrotoxicosis group. Similarly, tissue MDA levels were significantly higher in the thyrotoxicosis group compared to the other groups.
Conclusion: Consequently, heart tissue damage and differences in adropin levels were found in rats with thyrotoxicosis. It was observed that supportive vitamin D treatment helps to regulate these effects.

Kaynakça

  • 1. Devereaux D, Tewelde SZ. Hyperthyroidism and thyrotoxicosis. E Emerg Med Clin North Am. 2014;32(2):277-92. doi: 10.1016/j.emc.2013.12.001.
  • 2. Kut E, Atmaca H. Tirotoksikoz. Journal of Experimental and Clinical Medicine. 2012;29(4S):309-14. doi.org/10.5835/jecm.omu.29.s4.018
  • 3. Kim D. The Role of Vitamin D in Thyroid Diseases. International journal of molecular sciences. 2017;18(9):1949.doi: 10.3390/ijms18091949.
  • 4. Akkoyun H, Bayramoğlu M, Suat E, Çelebi F. Atatürk University J. Vet. Sci. D vitamini ve metabolizma için önemi. 2014;9(3):213-9. doi:10.17094/avbd.05043
  • 5. Paşaoğlu Yağcı H, Deniz R. Serum adropin and nitric oxide levels in missed abortus cases. J Surg Med. 2021;5(1):93-6. doi: 10.28982/josam.867760.
  • 6. Marczuk N, Cecerska-Heryć E, Jesionowska A, Dołęgowska B. Adropin - physiological and pathophysiological role. Postepy higieny i medycyny doswiadczalnej (Online). 2016;70(0):981-8. doi: 10.5604/17322693.1220082.
  • 7. Yu HY, Zhao P, Wu MC, Liu J, Yin W. Serum adropin levels are decreased in patients with acute myocardial infarction. Regulatory peptides. 2014;190-191:46-9. doi: 10.1016/j.regpep.2014.04.001.
  • 8. Lian W, Gu X, Qin Y, Zheng X. Elevated plasma levels of adropin in heart failure patients. Internal medicine (Tokyo, Japan). 2011;50(15):1523-7. doi: 10.2169/internalmedicine.50.5163.
  • 9. Deng J, Zhao R, Zhang Z, Wang J. Changes in vasoreactivity of rat large- and medium- sized arteries induced by hyperthyroidism. Experimental and toxicologic pathology: official journal of the Gesellschaft fur Toxikologische Pathologie. 2010;62(3):317-22. doi: 10.1016/j.etp.2009.04.007.
  • 10. Dabak DO, Kuloglu T, Ozercan MR. Effects of vitamin D3 (cholecalciferol) on adriamycin-induced nephrotoxicity. Renal failure. 2009;31(5):400-5. doi: 10.1080/08860220902883020.
  • 11. Kuloglu T, Aydin S, Eren MN, Yilmaz M, Sahin I, Kalayci M, et al. Irisin: a potentially candidate marker for myocardial infarction. Peptides. 2014;55:85-91. doi: 10.1016/j.peptides.2014.02.008.
  • 12. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods in enzymology. 1990;186:407-21. doi: 10.1016/0076-6879(90)86134-h.
  • 13. Trzepacz PT, Klein I, Roberts M, Greenhouse J, Levey GS. Graves' disease: an analysis of thyroid hormone levels and hyperthyroid signs and symptoms. The American journal of medicine. 1989;87(5):558-61. doi: 10.1016/s0002-9343(89)80614-x.
  • 14. Tamer G, Arik S, Tamer I, Coksert D. Relative vitamin D insufficiency in Hashimoto's thyroiditis. Thyroid : official journal of the American Thyroid Association. 2011;21(8):891-6. doi: 10.1089/thy.2009.0200.
  • 15. Bozkurt NC, Karbek B, Ucan B, Sahin M, Cakal E, Ozbek M, et al. The association between severity of vitamin D deficiency and Hashimoto's thyroiditis. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2013;19(3):479-84. doi: 10.4158/ep12376.Or.
  • 16. Shin DY, Kim KJ, Kim D, Hwang S, Lee EJ. Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei medical journal. 2014;55(2):476-81. doi: 10.3349/ymj.2014.55.2.476.
  • 17. Wang X, Quinn PJ. Vitamin E and its function in membranes. Progress in lipid research. 1999;38(4):309-36. doi: 10.1016/s0163-7827(99)00008-9.
  • 18. Wenclewska S, Szymczak-Pajor I, Drzewoski J, Bunk M, Śliwińska A. Vitamin D supplementation reduces both oxidative DNA damage and insulin resistance in the Elderly with Metabolic Disorders. International journal of molecular sciences. 2019;20(12). doi: 10.3390/ijms20122891.
  • 19. Kalkan A, Cakmak H, Erturk M, Kalkan K, Uzun F, Tasbulak O, et al. Adropin and Irisin in Patients with Cardiac Cachexia. Arquivos Brasileiros de Cardiologia. 2018;111. doi: 10.5935/abc.20180109.
  • 20. Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, et al. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell metabolism. 2008;8(6):468-81. doi: 10.1016/j.cmet.2008.10.011.
  • 21. Yang C, DeMars KM, Candelario-Jalil E. Age-Dependent Decrease in Adropin is associated with reduced levels of endothelial nitric oxide synthase and increased oxidative stress in the rat brain. Aging and disease. 2018;9(2):322-30. doi: 10.14336/ad.2017.0523.

Yıl 2022, Cilt: 6 Sayı: 3, 382 - 385, 01.03.2022
https://doi.org/10.28982/josam.961385

Öz

Kaynakça

  • 1. Devereaux D, Tewelde SZ. Hyperthyroidism and thyrotoxicosis. E Emerg Med Clin North Am. 2014;32(2):277-92. doi: 10.1016/j.emc.2013.12.001.
  • 2. Kut E, Atmaca H. Tirotoksikoz. Journal of Experimental and Clinical Medicine. 2012;29(4S):309-14. doi.org/10.5835/jecm.omu.29.s4.018
  • 3. Kim D. The Role of Vitamin D in Thyroid Diseases. International journal of molecular sciences. 2017;18(9):1949.doi: 10.3390/ijms18091949.
  • 4. Akkoyun H, Bayramoğlu M, Suat E, Çelebi F. Atatürk University J. Vet. Sci. D vitamini ve metabolizma için önemi. 2014;9(3):213-9. doi:10.17094/avbd.05043
  • 5. Paşaoğlu Yağcı H, Deniz R. Serum adropin and nitric oxide levels in missed abortus cases. J Surg Med. 2021;5(1):93-6. doi: 10.28982/josam.867760.
  • 6. Marczuk N, Cecerska-Heryć E, Jesionowska A, Dołęgowska B. Adropin - physiological and pathophysiological role. Postepy higieny i medycyny doswiadczalnej (Online). 2016;70(0):981-8. doi: 10.5604/17322693.1220082.
  • 7. Yu HY, Zhao P, Wu MC, Liu J, Yin W. Serum adropin levels are decreased in patients with acute myocardial infarction. Regulatory peptides. 2014;190-191:46-9. doi: 10.1016/j.regpep.2014.04.001.
  • 8. Lian W, Gu X, Qin Y, Zheng X. Elevated plasma levels of adropin in heart failure patients. Internal medicine (Tokyo, Japan). 2011;50(15):1523-7. doi: 10.2169/internalmedicine.50.5163.
  • 9. Deng J, Zhao R, Zhang Z, Wang J. Changes in vasoreactivity of rat large- and medium- sized arteries induced by hyperthyroidism. Experimental and toxicologic pathology: official journal of the Gesellschaft fur Toxikologische Pathologie. 2010;62(3):317-22. doi: 10.1016/j.etp.2009.04.007.
  • 10. Dabak DO, Kuloglu T, Ozercan MR. Effects of vitamin D3 (cholecalciferol) on adriamycin-induced nephrotoxicity. Renal failure. 2009;31(5):400-5. doi: 10.1080/08860220902883020.
  • 11. Kuloglu T, Aydin S, Eren MN, Yilmaz M, Sahin I, Kalayci M, et al. Irisin: a potentially candidate marker for myocardial infarction. Peptides. 2014;55:85-91. doi: 10.1016/j.peptides.2014.02.008.
  • 12. Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods in enzymology. 1990;186:407-21. doi: 10.1016/0076-6879(90)86134-h.
  • 13. Trzepacz PT, Klein I, Roberts M, Greenhouse J, Levey GS. Graves' disease: an analysis of thyroid hormone levels and hyperthyroid signs and symptoms. The American journal of medicine. 1989;87(5):558-61. doi: 10.1016/s0002-9343(89)80614-x.
  • 14. Tamer G, Arik S, Tamer I, Coksert D. Relative vitamin D insufficiency in Hashimoto's thyroiditis. Thyroid : official journal of the American Thyroid Association. 2011;21(8):891-6. doi: 10.1089/thy.2009.0200.
  • 15. Bozkurt NC, Karbek B, Ucan B, Sahin M, Cakal E, Ozbek M, et al. The association between severity of vitamin D deficiency and Hashimoto's thyroiditis. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2013;19(3):479-84. doi: 10.4158/ep12376.Or.
  • 16. Shin DY, Kim KJ, Kim D, Hwang S, Lee EJ. Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei medical journal. 2014;55(2):476-81. doi: 10.3349/ymj.2014.55.2.476.
  • 17. Wang X, Quinn PJ. Vitamin E and its function in membranes. Progress in lipid research. 1999;38(4):309-36. doi: 10.1016/s0163-7827(99)00008-9.
  • 18. Wenclewska S, Szymczak-Pajor I, Drzewoski J, Bunk M, Śliwińska A. Vitamin D supplementation reduces both oxidative DNA damage and insulin resistance in the Elderly with Metabolic Disorders. International journal of molecular sciences. 2019;20(12). doi: 10.3390/ijms20122891.
  • 19. Kalkan A, Cakmak H, Erturk M, Kalkan K, Uzun F, Tasbulak O, et al. Adropin and Irisin in Patients with Cardiac Cachexia. Arquivos Brasileiros de Cardiologia. 2018;111. doi: 10.5935/abc.20180109.
  • 20. Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, et al. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell metabolism. 2008;8(6):468-81. doi: 10.1016/j.cmet.2008.10.011.
  • 21. Yang C, DeMars KM, Candelario-Jalil E. Age-Dependent Decrease in Adropin is associated with reduced levels of endothelial nitric oxide synthase and increased oxidative stress in the rat brain. Aging and disease. 2018;9(2):322-30. doi: 10.14336/ad.2017.0523.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Araştırma makalesi
Yazarlar

Hasan AYDIN
ADIYAMAN UNIVERSITY, FACULTY OF PHARMACY
0000-0002-1955-6178
Türkiye


Ahmet TÜRK
ADIYAMAN UNIVERSITY, SCHOOL OF MEDICINE
0000-0003-0903-3522
Türkiye


Abdullah KARADAĞ
ADIYAMAN UNIVERSITY, SCHOOL OF MEDICINE
0000-0003-3620-9589
Türkiye

Destekleyen Kurum This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Proje Numarası xxxxxxxxx
Yayımlanma Tarihi 1 Mart 2022
Yayınlandığı Sayı Yıl 2022 Cilt: 6 Sayı: 3

Kaynak Göster

Bibtex @araştırma makalesi { josam961385, journal = {Journal of Surgery and Medicine}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Selçuk BAŞAK}, year = {2022}, volume = {6}, number = {3}, pages = {382 - 385}, doi = {10.28982/josam.961385}, title = {Effects of vitamin D treatment on the heart tissue and adropin levels in thyrotoxicosis rats}, key = {cite}, author = {Aydın, Hasan and Türk, Ahmet and Karadağ, Abdullah} }
APA Aydın, H. , Türk, A. & Karadağ, A. (2022). Effects of vitamin D treatment on the heart tissue and adropin levels in thyrotoxicosis rats . Journal of Surgery and Medicine , 6 (3) , 382-385 . DOI: 10.28982/josam.961385
MLA Aydın, H. , Türk, A. , Karadağ, A. "Effects of vitamin D treatment on the heart tissue and adropin levels in thyrotoxicosis rats" . Journal of Surgery and Medicine 6 (2022 ): 382-385 <https://dergipark.org.tr/tr/pub/josam/issue/68748/961385>
Chicago Aydın, H. , Türk, A. , Karadağ, A. "Effects of vitamin D treatment on the heart tissue and adropin levels in thyrotoxicosis rats". Journal of Surgery and Medicine 6 (2022 ): 382-385
RIS TY - JOUR T1 - Effects of vitamin D treatment on the heart tissue and adropin levels in thyrotoxicosis rats AU - HasanAydın, AhmetTürk, AbdullahKaradağ Y1 - 2022 PY - 2022 N1 - doi: 10.28982/josam.961385 DO - 10.28982/josam.961385 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 382 EP - 385 VL - 6 IS - 3 SN - -2602-2079 M3 - doi: 10.28982/josam.961385 UR - https://doi.org/10.28982/josam.961385 Y2 - 2022 ER -
EndNote %0 Journal of Surgery and Medicine Effects of vitamin D treatment on the heart tissue and adropin levels in thyrotoxicosis rats %A Hasan Aydın , Ahmet Türk , Abdullah Karadağ %T Effects of vitamin D treatment on the heart tissue and adropin levels in thyrotoxicosis rats %D 2022 %J Journal of Surgery and Medicine %P -2602-2079 %V 6 %N 3 %R doi: 10.28982/josam.961385 %U 10.28982/josam.961385
ISNAD Aydın, Hasan , Türk, Ahmet , Karadağ, Abdullah . "Effects of vitamin D treatment on the heart tissue and adropin levels in thyrotoxicosis rats". Journal of Surgery and Medicine 6 / 3 (Mart 2022): 382-385 . https://doi.org/10.28982/josam.961385
AMA Aydın H. , Türk A. , Karadağ A. Effects of vitamin D treatment on the heart tissue and adropin levels in thyrotoxicosis rats. J Surg Med. 2022; 6(3): 382-385.
Vancouver Aydın H. , Türk A. , Karadağ A. Effects of vitamin D treatment on the heart tissue and adropin levels in thyrotoxicosis rats. Journal of Surgery and Medicine. 2022; 6(3): 382-385.
IEEE H. Aydın , A. Türk ve A. Karadağ , "Effects of vitamin D treatment on the heart tissue and adropin levels in thyrotoxicosis rats", Journal of Surgery and Medicine, c. 6, sayı. 3, ss. 382-385, Mar. 2022, doi:10.28982/josam.961385