Investigation of The Utilization of Alginate/Chitosan Nanoparticles for Tamoxifen Delivery

Çağdaş Sunna; Arife Alev Karagözler

doi:10.18596/jotcsa.1858317

Investigation of The Utilization of Alginate/Chitosan Nanoparticles for Tamoxifen Delivery

Abstract

In this work, the usability of tamoxifen-loaded alginate/chitosan nanoparticles as a drug release system was investigated. Optimal conditions for nanoparticle preparation were determined, and the nanoparticles were characterized using Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), and scanning electron microscopy (SEM). According to AFM and SEM images, the nanoparticles ranged in size from 50 to 800 nm. The release of tamoxifen from nanoparticles in simulated stomach and small intestine media was investigated, and it was found that after 5 h, only 8% of the immobilized drug was released in the stomach medium, whereas 92% was released in the small intestine medium. The results show that tamoxifen-loaded alginate/chitosan nanoparticles have the potential to serve as a controlled drug-delivery system.

Keywords

Supporting Institution

Aydın Adnan Menderes University

Project Number

ADU FEF 11021

Ethical Statement

The authors declare that they have no conflict of interest. All of the authors consent to participate and publish the manuscript.

Thanks

The authors thank to Aydın Adnan Menderes University Research Fund for the financial support of this study under a project (Project Number: ADU FEF 11021).

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Details

Primary Language

English

Subjects

Bioinorganic Chemistry, Nanochemistry, Molecular Medicine

Journal Section

Research Article

Authors

Çağdaş Sunna ^*
0000-0002-8212-911X
Türkiye

Arife Alev Karagözler
0000-0002-1884-0089
Türkiye

Publication Date

March 9, 2026

Submission Date

January 7, 2026

Acceptance Date

February 9, 2026

Published in Issue

Year 2026 Number: 2026-1

DOI

https://doi.org/10.18596/jotcsa.1858317

IZ

https://izlik.org/JA23RE86AK

Cite

RIS / Bibtex

APA

Sunna, Ç., & Karagözler, A. A. (2026). Investigation of The Utilization of Alginate/Chitosan Nanoparticles for Tamoxifen Delivery. Journal of the Turkish Chemical Society Section A: Chemistry, 2026-1, 1-10. https://doi.org/10.18596/jotcsa.1858317

AMA

1.Sunna Ç, Karagözler AA. Investigation of The Utilization of Alginate/Chitosan Nanoparticles for Tamoxifen Delivery. JOTCSA. 2026;(2026-1):1-10. doi:10.18596/jotcsa.1858317

Chicago

Sunna, Çağdaş, and Arife Alev Karagözler. 2026. “Investigation of The Utilization of Alginate Chitosan Nanoparticles for Tamoxifen Delivery”. Journal of the Turkish Chemical Society Section A: Chemistry, no. 2026-1: 1-10. https://doi.org/10.18596/jotcsa.1858317.

EndNote

Sunna Ç, Karagözler AA (March 1, 2026) Investigation of The Utilization of Alginate/Chitosan Nanoparticles for Tamoxifen Delivery. Journal of the Turkish Chemical Society Section A: Chemistry 2026-1 1–10.

IEEE

[1]Ç. Sunna and A. A. Karagözler, “Investigation of The Utilization of Alginate/Chitosan Nanoparticles for Tamoxifen Delivery”, JOTCSA, no. 2026-1, pp. 1–10, Mar. 2026, doi: 10.18596/jotcsa.1858317.

ISNAD

Sunna, Çağdaş - Karagözler, Arife Alev. “Investigation of The Utilization of Alginate Chitosan Nanoparticles for Tamoxifen Delivery”. Journal of the Turkish Chemical Society Section A: Chemistry. 2026-1 (March 1, 2026): 1-10. https://doi.org/10.18596/jotcsa.1858317.

JAMA

1.Sunna Ç, Karagözler AA. Investigation of The Utilization of Alginate/Chitosan Nanoparticles for Tamoxifen Delivery. JOTCSA. 2026;:1–10.

MLA

Sunna, Çağdaş, and Arife Alev Karagözler. “Investigation of The Utilization of Alginate Chitosan Nanoparticles for Tamoxifen Delivery”. Journal of the Turkish Chemical Society Section A: Chemistry, no. 2026-1, Mar. 2026, pp. 1-10, doi:10.18596/jotcsa.1858317.

Vancouver

1.Çağdaş Sunna, Arife Alev Karagözler. Investigation of The Utilization of Alginate/Chitosan Nanoparticles for Tamoxifen Delivery. JOTCSA. 2026 Mar. 1;(2026-1):1-10. doi:10.18596/jotcsa.1858317