In the present study
for the first time in the literature, novel S-substituted bioactive
anthraquinone compound were synthesized with a new, easy and less energetic
reaction method (Patent Number: TR2016/19610) from 1-chloro-9,10-dihydrodiagnosisxy-anthraquinone
and butyl-3-mercaptopropionate. The resultant structure present remarkable
biological properties It was purified by column chromatography. All obtained
structures were characterized with spectroscopic methods (NMR, MS, FT-IR, UV
etc). Antimicrobial properties of bioactive compound were determined as well.
The resultant thioanthraquinone compound has been synthesized for the first
time in the literature and its applications as a biomaterial were discussed in
the present study.
Subsequently, biodegradable electrospun mats were
produced via electrospinning method for their usage in treatment as a
biomaterial. Structural (FTIR), morphological (FEG-SEM) biological
(antimicrobial and in-vitro tests) and mechanical (tensile testing) characterizations
were conducted for these nanobiomaterials. Presenting an advantage of the novel
antimicrobial compound, the produced electrospun nanobiocomposites exhibited
remarkable biological, mechanical properties. With a purposeful compound
synthesis and a subsequent nanobiocomposite production, the obtained
electrospun mats are good canditates for biomaterials for tissue engineering
purposes and wound healing materials.
Anthraquinone synthesis electrospun mat biomaterial biodegradable material biomaterial
Birincil Dil | İngilizce |
---|---|
Konular | Kimya Mühendisliği |
Bölüm | Makaleler |
Yazarlar | |
Yayımlanma Tarihi | 1 Eylül 2018 |
Gönderilme Tarihi | 9 Mayıs 2018 |
Kabul Tarihi | 20 Eylül 2018 |
Yayımlandığı Sayı | Yıl 2018 Cilt: 5 Sayı: 3 |