Research Article

Organo-particles synthesized from sesame oil and castor oil, and anticancer activity in pancreas cancer cells

Volume: 2026 Number: 2 November 5, 2026

Organo-particles synthesized from sesame oil and castor oil, and anticancer activity in pancreas cancer cells

Abstract

This study aimed to synthesize sesame oil (SO)- and castor oil (CO)-derived organo-particles to preserve the biological activity of these natural oils while enhancing their cellular uptake and to comprehensively evaluate their physicochemical and biological properties. The novelty of this study lies in the one-step synthesis of sesame oil- and castor oil-based organo-particles followed by the integrated evaluation of their antioxidant, antimicrobial, hemocompatibility, and anticancer activities. p(SO) and p(CO) organo-particles were synthesized by one-step free-radical addition polymerization and characterized using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and dynamic light scattering (DLS). Their antioxidant, antimicrobial, hemolytic, and blood-clotting properties were also investigated. Furthermore, the cytotoxic effects of the synthesized organo-particles were evaluated by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay using L-929 fibroblasts and Capan-1 pancreatic cancer cell lines. The synthesized organo-particles exhibited particle sizes ranging from 300–1000 nm for p(CO) and 400–673 nm for p(SO). p(CO) completely inhibited the growth of Staphylococcus aureus, whereas both organo-particles demonstrated good hemocompatibility. In the MTT assay, p(CO) reduced the viability of Capan-1 pancreatic cancer cells to 60.32 ± 3.36%, while p(SO) did not exhibit cytotoxic activity (105.25 ± 1.39%). In contrast, both organo-particles maintained high viability in L-929 fibroblast cells, indicating favorable biocompatibility. These findings demonstrate that p(CO) organo-particles possess promising anticancer potential against pancreatic cancer cells while exhibiting acceptable biocompatibility, supporting their further investigation for biomedical applications.

Keywords

References

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Details

Primary Language

English

Subjects

Biomaterial

Journal Section

Research Article

Publication Date

November 5, 2026

Submission Date

March 7, 2026

Acceptance Date

October 13, 2026

Published in Issue

Year 2026 Volume: 2026 Number: 2

APA
Alpaslan, D., Erşen Dudu, T., Moran, B., Aktaş, N., & Türk, M. (2026). Organo-particles synthesized from sesame oil and castor oil, and anticancer activity in pancreas cancer cells. Journal of the Turkish Chemical Society Section B: Chemical Engineering, 2026(2), 1-17. https://doi.org/10.58692/jotcsb.1904879
AMA
1.Alpaslan D, Erşen Dudu T, Moran B, Aktaş N, Türk M. Organo-particles synthesized from sesame oil and castor oil, and anticancer activity in pancreas cancer cells. JOTCSB. 2026;2026(2):1-17. doi:10.58692/jotcsb.1904879
Chicago
Alpaslan, Duygu, Tuba Erşen Dudu, Büşra Moran, Nahit Aktaş, and Mustafa Türk. 2026. “Organo-Particles Synthesized from Sesame Oil and Castor Oil, and Anticancer Activity in Pancreas Cancer Cells”. Journal of the Turkish Chemical Society Section B: Chemical Engineering 2026 (2): 1-17. https://doi.org/10.58692/jotcsb.1904879.
EndNote
Alpaslan D, Erşen Dudu T, Moran B, Aktaş N, Türk M (November 1, 2026) Organo-particles synthesized from sesame oil and castor oil, and anticancer activity in pancreas cancer cells. Journal of the Turkish Chemical Society Section B: Chemical Engineering 2026 2 1–17.
IEEE
[1]D. Alpaslan, T. Erşen Dudu, B. Moran, N. Aktaş, and M. Türk, “Organo-particles synthesized from sesame oil and castor oil, and anticancer activity in pancreas cancer cells”, JOTCSB, vol. 2026, no. 2, pp. 1–17, Nov. 2026, doi: 10.58692/jotcsb.1904879.
ISNAD
Alpaslan, Duygu - Erşen Dudu, Tuba - Moran, Büşra - Aktaş, Nahit - Türk, Mustafa. “Organo-Particles Synthesized from Sesame Oil and Castor Oil, and Anticancer Activity in Pancreas Cancer Cells”. Journal of the Turkish Chemical Society Section B: Chemical Engineering 2026/2 (November 1, 2026): 1-17. https://doi.org/10.58692/jotcsb.1904879.
JAMA
1.Alpaslan D, Erşen Dudu T, Moran B, Aktaş N, Türk M. Organo-particles synthesized from sesame oil and castor oil, and anticancer activity in pancreas cancer cells. JOTCSB. 2026;2026:1–17.
MLA
Alpaslan, Duygu, et al. “Organo-Particles Synthesized from Sesame Oil and Castor Oil, and Anticancer Activity in Pancreas Cancer Cells”. Journal of the Turkish Chemical Society Section B: Chemical Engineering, vol. 2026, no. 2, Nov. 2026, pp. 1-17, doi:10.58692/jotcsb.1904879.
Vancouver
1.Duygu Alpaslan, Tuba Erşen Dudu, Büşra Moran, Nahit Aktaş, Mustafa Türk. Organo-particles synthesized from sesame oil and castor oil, and anticancer activity in pancreas cancer cells. JOTCSB. 2026 Nov. 1;2026(2):1-17. doi:10.58692/jotcsb.1904879

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J. Turk. Chem. Soc., Sect. B: Chem. Eng. (JOTCSB)