Yıl 2012, Cilt 4 , Sayı 3, Sayfalar 1 - 5 2012-11-22

The Role of Metoclopramide for Treatment of Functional Constipation in Children: A Double Blind Study

Seyed Mohsen DEHGHANİ [1] , Mohammad Hadi IMANİEH [2] , Asma ERJAEE [3] , Hossein MORAVEJ [4] , Razie MATİN [5] , Mahmood HAGHİGHAT [6]


Background: The treatment of functional constipation is a concern worldwide. Various studies have evaluated the effect of prokinetic agents such as cisapride in management of chronic constipation, however due to the possible lethal side effects, its consumption has been limited. In this study we assessed the effect of metoclopramide a drug with similar prokinetic effects and less side effects in management of chronic constipation. Method: All pediatric patients less than 12 year of age with diagnosis of chronic functional constipation according to the ROME III criteria were included during the study period. Through this double blind study, patients were randomly divided into two groups. Group A received polyethylene glycol and placebo and group B polyethylene glycol with metoclopramide. The two groups were compared regarding their symptoms and Rome III criteria following therapy. Results: Of the total 102 pediatric patients, 50 subjects completed regime A and 52 patients, regime B. The interval between defecations prior to treatment was 4.8±2.7 days in subjects of group A and 5.9±3.6 days in those of group B. Response to treatment; defined as decrease in signs and symptoms that would not fulfill Rome III criteria, and without any recurrence of fecal impaction with discontinuation of medication, was almost equal in both groups: 84% (42 of 50) in patients receiving regime A vs. 84.6% (44 of 52) in regime B group (p=0.39). Conclusion: In this study we achieved no significant response from consumption of metoclopramide as a prokinetic agent in the treatment of chronic constipation of children.
Constipation; Metoclopramide; Treatment
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Birincil Dil en
Bölüm Original Articles
Yazarlar

Yazar: Seyed Mohsen DEHGHANİ

Yazar: Mohammad Hadi IMANİEH

Yazar: Asma ERJAEE

Yazar: Hossein MORAVEJ

Yazar: Razie MATİN

Yazar: Mahmood HAGHİGHAT

Tarihler

Yayımlanma Tarihi : 22 Kasım 2012

Bibtex @ { jps202167, journal = {Journal of Pediatric Sciences}, issn = {}, eissn = {1309-1247}, address = {}, publisher = {Bilal YILDIZ}, year = {2012}, volume = {4}, pages = {1 - 5}, doi = {10.17334/jps.13540}, title = {The Role of Metoclopramide for Treatment of Functional Constipation in Children: A Double Blind Study}, key = {cite}, author = {Dehghani̇, Seyed Mohsen and Imani̇eh, Mohammad Hadi and Erjaee, Asma and Moravej, Hossein and Mati̇n, Razie and Haghi̇ghat, Mahmood} }
APA Dehghani̇, S , Imani̇eh, M , Erjaee, A , Moravej, H , Mati̇n, R , Haghi̇ghat, M . (2012). The Role of Metoclopramide for Treatment of Functional Constipation in Children: A Double Blind Study . Journal of Pediatric Sciences , 4 (3) , 1-5 . Retrieved from https://dergipark.org.tr/tr/pub/jps/issue/19087/202167
MLA Dehghani̇, S , Imani̇eh, M , Erjaee, A , Moravej, H , Mati̇n, R , Haghi̇ghat, M . "The Role of Metoclopramide for Treatment of Functional Constipation in Children: A Double Blind Study" . Journal of Pediatric Sciences 4 (2012 ): 1-5 <https://dergipark.org.tr/tr/pub/jps/issue/19087/202167>
Chicago Dehghani̇, S , Imani̇eh, M , Erjaee, A , Moravej, H , Mati̇n, R , Haghi̇ghat, M . "The Role of Metoclopramide for Treatment of Functional Constipation in Children: A Double Blind Study". Journal of Pediatric Sciences 4 (2012 ): 1-5
RIS TY - JOUR T1 - The Role of Metoclopramide for Treatment of Functional Constipation in Children: A Double Blind Study AU - Seyed Mohsen Dehghani̇ , Mohammad Hadi Imani̇eh , Asma Erjaee , Hossein Moravej , Razie Mati̇n , Mahmood Haghi̇ghat Y1 - 2012 PY - 2012 N1 - DO - T2 - Journal of Pediatric Sciences JF - Journal JO - JOR SP - 1 EP - 5 VL - 4 IS - 3 SN - -1309-1247 M3 - UR - Y2 - 2021 ER -
EndNote %0 Journal of Pediatric Sciences The Role of Metoclopramide for Treatment of Functional Constipation in Children: A Double Blind Study %A Seyed Mohsen Dehghani̇ , Mohammad Hadi Imani̇eh , Asma Erjaee , Hossein Moravej , Razie Mati̇n , Mahmood Haghi̇ghat %T The Role of Metoclopramide for Treatment of Functional Constipation in Children: A Double Blind Study %D 2012 %J Journal of Pediatric Sciences %P -1309-1247 %V 4 %N 3 %R %U
ISNAD Dehghani̇, Seyed Mohsen , Imani̇eh, Mohammad Hadi , Erjaee, Asma , Moravej, Hossein , Mati̇n, Razie , Haghi̇ghat, Mahmood . "The Role of Metoclopramide for Treatment of Functional Constipation in Children: A Double Blind Study". Journal of Pediatric Sciences 4 / 3 (Kasım 2012): 1-5 .
AMA Dehghani̇ S , Imani̇eh M , Erjaee A , Moravej H , Mati̇n R , Haghi̇ghat M . The Role of Metoclopramide for Treatment of Functional Constipation in Children: A Double Blind Study. Journal of Pediatric Sciences. 2012; 4(3): 1-5.
Vancouver Dehghani̇ S , Imani̇eh M , Erjaee A , Moravej H , Mati̇n R , Haghi̇ghat M . The Role of Metoclopramide for Treatment of Functional Constipation in Children: A Double Blind Study. Journal of Pediatric Sciences. 2012; 4(3): 1-5.
IEEE S. Dehghani̇ , M. Imani̇eh , A. Erjaee , H. Moravej , R. Mati̇n ve M. Haghi̇ghat , "The Role of Metoclopramide for Treatment of Functional Constipation in Children: A Double Blind Study", Journal of Pediatric Sciences, c. 4, sayı. 3, ss. 1-5, Kas. 2012, doi:10.17334/jps.13540

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