1. DergiPark
  2. Journal of Pediatric Sciences
  3. Arşiv
  4. Cilt 4, Sayı 3
Yıl 2012, Cilt 4 , Sayı 3, Sayfalar 1 - 6 2012-08-17

Effectiveness of 3% saline versus mannitol in children with cerebral oedema of non traumatic etiology

Kumaraguru D [1] , Poovazhagi VARADARAJAN [2] , Shanthi SANGAREDDİ [3] , Ramachandran PADMANABHAN [4] , Jeyachandran P [5]

Öz

Objective: A randomized controlled trial was undertaken at the pediatric intensive care department of a tertiary care Pediatric hospital at Chennai, to evaluate the effectiveness of 3% saline as an anti-edema measure in comparison to mannitol in children with non-traumatic coma. Subjects: The study comprised of 40 children with cerebral edema in each group. Outcome measures: The outcome was analyzed in terms of survival/death, duration of coma and complications. Results: Study parameters like age, gender, Glasgow coma scale, etiology of coma, signs of cerebral edema and duration of coma were comparable among the two groups and did not reveal statistically significant difference. Among the complications shock(p- 0.03) and dehydration (p-0.045) were more common in children who received mannitol and hypernatremia(p-0.026) was common in children who received 3% saline. The mortality rates among the two groups did not reveal statistically significant difference(p-0.07). Conclusions: In the treatment of cerebral edema of non traumatic origin in children, 3% saline can be considered as effective and safe as mannitol.

Anahtar Kelimeler

Mannitol, 3% saline, cerebral edema

Kaynakça

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  • Zornow MH. Hypertonic saline as a safe and efficacious treatment of intracranial hypertension. J Neurosurg Anesthesiol 1996;8:175-177.
  • Qureshi AI, Suarez JI, Bhardwaj A, Mirski M, Schnitzer MS, Hanley DF,et al. Use of hypertonic saline/ acetate infusion in the treatment of cerebral edema: Effect on intracranial pressure and lateral displacement of the brain. Crit Care Med 1998;26: 440-446.
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  • Wakai A, Roberts I, Schierhout G. Mannitol for acute traumatic brain injury. Cochrane Database Syst Rev 2007; 1:CD001049.
  • Bhardwaj A, Ulatowski JA. Hypertonic saline in brain injury. Curr Opin Crit Care 2004; 10:126–131.
  • Suarez JL. Hypertonic saline for cerebral edema and elevated intracranial pressure. Cleveland Clin J Med 2004; 71 (suppl 1):S9–S13.
  • Gemma M, Cozzi S, Tommasino C, Mungo M, Calvi MR, Capriani A, et al. 7.5% hypertonic saline versus 20% mannitol during elective neurosurgical supratentorial procedures. J Neurosurg Anesth 1997; 9:329–334.

Ayrıntılar

Birincil Dil en
Bölüm Original Articles
Yazarlar

Yazar: Kumaraguru D

Yazar: Poovazhagi VARADARAJAN

Yazar: Shanthi SANGAREDDİ

Yazar: Ramachandran PADMANABHAN

Yazar: Jeyachandran P
Tarihler

Yayımlanma Tarihi : 17 Ağustos 2012

Kaynak Göster

Bibtex @ { jps202226, journal = {Journal of Pediatric Sciences}, issn = {}, eissn = {1309-1247}, address = {}, publisher = {Bilal YILDIZ}, year = {2012}, volume = {4}, pages = {1 - 6}, doi = {10.17334/jps.30271}, title = {Effectiveness of 3\% saline versus mannitol in children with cerebral oedema of non traumatic etiology}, key = {cite}, author = {D, Kumaraguru and Varadarajan, Poovazhagi and Sangareddi̇, Shanthi and Padmanabhan, Ramachandran and P, Jeyachandran} }
APA D, K , Varadarajan, P , Sangareddi̇, S , Padmanabhan, R , P, J . (2012). Effectiveness of 3% saline versus mannitol in children with cerebral oedema of non traumatic etiology . Journal of Pediatric Sciences , 4 (3) , 1-6 . Retrieved from https://dergipark.org.tr/tr/pub/jps/issue/19087/202226
MLA D, K , Varadarajan, P , Sangareddi̇, S , Padmanabhan, R , P, J . "Effectiveness of 3% saline versus mannitol in children with cerebral oedema of non traumatic etiology" . Journal of Pediatric Sciences 4 (2012 ): 1-6 <https://dergipark.org.tr/tr/pub/jps/issue/19087/202226>
Chicago D, K , Varadarajan, P , Sangareddi̇, S , Padmanabhan, R , P, J . "Effectiveness of 3% saline versus mannitol in children with cerebral oedema of non traumatic etiology". Journal of Pediatric Sciences 4 (2012 ): 1-6
RIS TY - JOUR T1 - Effectiveness of 3% saline versus mannitol in children with cerebral oedema of non traumatic etiology AU - Kumaraguru D , Poovazhagi Varadarajan , Shanthi Sangareddi̇ , Ramachandran Padmanabhan , Jeyachandran P Y1 - 2012 PY - 2012 N1 - DO - T2 - Journal of Pediatric Sciences JF - Journal JO - JOR SP - 1 EP - 6 VL - 4 IS - 3 SN - -1309-1247 M3 - UR - Y2 - 2021 ER -
EndNote %0 Journal of Pediatric Sciences Effectiveness of 3% saline versus mannitol in children with cerebral oedema of non traumatic etiology %A Kumaraguru D , Poovazhagi Varadarajan , Shanthi Sangareddi̇ , Ramachandran Padmanabhan , Jeyachandran P %T Effectiveness of 3% saline versus mannitol in children with cerebral oedema of non traumatic etiology %D 2012 %J Journal of Pediatric Sciences %P -1309-1247 %V 4 %N 3 %R %U
ISNAD D, Kumaraguru , Varadarajan, Poovazhagi , Sangareddi̇, Shanthi , Padmanabhan, Ramachandran , P, Jeyachandran . "Effectiveness of 3% saline versus mannitol in children with cerebral oedema of non traumatic etiology". Journal of Pediatric Sciences 4 / 3 (Ağustos 2012): 1-6 .
AMA D K , Varadarajan P , Sangareddi̇ S , Padmanabhan R , P J . Effectiveness of 3% saline versus mannitol in children with cerebral oedema of non traumatic etiology. Journal of Pediatric Sciences. 2012; 4(3): 1-6.
Vancouver D K , Varadarajan P , Sangareddi̇ S , Padmanabhan R , P J . Effectiveness of 3% saline versus mannitol in children with cerebral oedema of non traumatic etiology. Journal of Pediatric Sciences. 2012; 4(3): 1-6.
IEEE K. D , P. Varadarajan , S. Sangareddi̇ , R. Padmanabhan ve J. P , "Effectiveness of 3% saline versus mannitol in children with cerebral oedema of non traumatic etiology", Journal of Pediatric Sciences, c. 4, sayı. 3, ss. 1-6, Ağu. 2012, doi:10.17334/jps.30271
Makalenin Yazarları
Kumaraguru D [1]
Poovazhagi VARADARAJAN [2]
Shanthi SANGAREDDİ [3]
Ramachandran PADMANABHAN [4]
Jeyachandran P [5]
Arşiv