LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae)

Sefa Gözcü; Zeynep Akşit; Samed Şimşek; Ali Kandemir; Ali Aydın; Mustafa Abdullah Yılmaz; Hüseyin Akşit

LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae)

Abstract

The study aimed to comprehensively identify the phenolic fingerprint of Morina persica L. (Caprifoliaceae) and evaluate its various biological activities. LC-MS/MS analysis of 70% Morina persica methanol extract revealed the presence of 27 phytochemicals, with quinic acid, chlorogenic acid, and rutin being the major phenolics. The antioxidant, antibacterial, antiproliferative, and cytotoxic activities were evaluated for biological screening. The results showed that the methanolic extract of M. persica has a moderate DPPH radical scavenging and ferric-reducing capacity, indicating antioxidant activity. M. persica was observed to have a sufficient antiproliferative effect against cancer cells and low cytotoxicity against normal cells. Moreover, M. persica demonstrated good antibacterial activity against Clostridium perfringens, Enterococcus faecalis, and Escherichia coli. These data suggest that the methanolic extract of M. persica could be considered both an industrial source of quinic acid and a potential biologically active ingredient for developing drug formulations.

Keywords

References

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Details

Primary Language

English

Subjects

Pharmacognosy

Journal Section

Research Article

Authors

Sefa Gözcü ^*
0000-0002-0735-4229
Türkiye

Zeynep Akşit
0000-0002-0349-0223
Türkiye

Samed Şimşek
0000-0001-8451-3425
Türkiye

Ali Kandemir
0000-0003-1902-9631
Türkiye

Ali Aydın
Türkiye

Mustafa Abdullah Yılmaz
0000-0002-4090-7227
Türkiye

Hüseyin Akşit
0000-0002-1509-851X
Türkiye

Publication Date

June 28, 2025

Submission Date

August 3, 2023

Acceptance Date

November 7, 2023

Published in Issue

Year 2024 Volume: 28 Number: 4

IZ

https://izlik.org/JA89KC32UH

Cite

RIS / Bibtex

APA

Gözcü, S., Akşit, Z., Şimşek, S., Kandemir, A., Aydın, A., Yılmaz, M. A., & Akşit, H. (2025). LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae). Journal of Research in Pharmacy, 28(4), 961-973. https://izlik.org/JA89KC32UH

AMA

1.Gözcü S, Akşit Z, Şimşek S, et al. LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae). J. Res. Pharm. 2025;28(4):961-973. https://izlik.org/JA89KC32UH

Chicago

Gözcü, Sefa, Zeynep Akşit, Samed Şimşek, et al. 2025. “LC-MS MS Characterization and Biological Activities of Morina Persica L. (Caprifoliaceae)”. Journal of Research in Pharmacy 28 (4): 961-73. https://izlik.org/JA89KC32UH.

EndNote

Gözcü S, Akşit Z, Şimşek S, Kandemir A, Aydın A, Yılmaz MA, Akşit H (July 1, 2025) LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae). Journal of Research in Pharmacy 28 4 961–973.

IEEE

[1]S. Gözcü et al., “LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae)”, J. Res. Pharm., vol. 28, no. 4, pp. 961–973, July 2025, [Online]. Available: https://izlik.org/JA89KC32UH

ISNAD

Gözcü, Sefa - Akşit, Zeynep - Şimşek, Samed - Kandemir, Ali - Aydın, Ali - Yılmaz, Mustafa Abdullah - Akşit, Hüseyin. “LC-MS MS Characterization and Biological Activities of Morina Persica L. (Caprifoliaceae)”. Journal of Research in Pharmacy 28/4 (July 1, 2025): 961-973. https://izlik.org/JA89KC32UH.

JAMA

1.Gözcü S, Akşit Z, Şimşek S, Kandemir A, Aydın A, Yılmaz MA, Akşit H. LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae). J. Res. Pharm. 2025;28:961–973.

MLA

Gözcü, Sefa, et al. “LC-MS MS Characterization and Biological Activities of Morina Persica L. (Caprifoliaceae)”. Journal of Research in Pharmacy, vol. 28, no. 4, July 2025, pp. 961-73, https://izlik.org/JA89KC32UH.

Vancouver

1.Sefa Gözcü, Zeynep Akşit, Samed Şimşek, Ali Kandemir, Ali Aydın, Mustafa Abdullah Yılmaz, Hüseyin Akşit. LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae). J. Res. Pharm. [Internet]. 2025 Jul. 1;28(4):961-73. Available from: https://izlik.org/JA89KC32UH