HAYVANSAL KAYNAKLI GIDALARDAN İZOLE EDİLEN CAMPYLOBACTER TÜRLERİNDE ANTİBİYOTİK DİRENCİ

Yıl 2023, Cilt: 2 Sayı: 1, 95 - 106, 16.06.2023

Ziyadin Elşebib Beren Başaran Kahraman

Öz

Tüm dünyada Campylobacter türlerinin meydana getirdiği hastalıklar hayvan
yetiştiriciliği ve halk sağlığı açısından önemli bir sorun teşkil etmektedir. Campylobacter türleri
dünya çapında gıda kaynaklı hastalıkların en yaygın etkenidir. İnsanlar en çok kontamine
gıdaları yiyerek infekte olurlar. Antimikrobiyal tedavi sadece daha şiddetli hastalığı olan
hastalarda ve bağışıklığı zayıf olan hastalarda gereklidir. Bu infeksiyonları tedavi etmek için
kullanılan en yaygın antimikrobiyal ajanlar makrolidler ve florokinolonlardır. Tetrasiklin ise
klinik tedavide alternatif bir seçenek olarak önerilmiş ancak pratikte çok sık
kullanılmamaktadır. Son yıllarda florokinolon, makrolid, aminoglikozid ve beta-laktamlar gibi
diğer antimikrobiyallere karşı direnç bildirilmektedir. Prevalansları ve spesifik adaptasyonları
göz önüne alındığında, Campylobacter türlerindeki antibiyotik direnci insan sağlığı için önemli
bir tehdit oluşturmaktadır. Bu derlemede, hastalıkların tedavisinde yararlı olan antimikrobiyal
ajanlara karşı ortaya çıkan direnç modelleri sunulmaktadır.

Anahtar Kelimeler

antimikrobiyal direnç, campylobacter, florokinolon, makrolid

Kaynakça

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