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Bioactivities of Merremia emarginata (Burm.f.) Hallier f. extracts and isolated compounds

Yıl 2021, Cilt 3, Sayı 1, 110 - 119, 05.07.2021

Öz

Merremia emarginata (Burm.f.) Hallier f. is a wild herb that belongs to the Convolvulaceae family. It is used to treat diabetes, epilepsy, rheumatism, kidney and liver disorders in various traditional medicines. Compounds including caffeic acid, rosmeric acid, scopoletin, tetritol, and vanillic acid have been isolated from various parts of this plant species. This comprehensive review work aims to analyze, summarize, and document the bioactivities related to published studies involving M. emarginata. PubMed, ScienceDirect, Scopus, Semantic Scholar, and Web of Science electronic databases were used to obtain the relevant published articles from 1900 to May 2021. There is in vivo and in vitro scientific evidence is currently available for various bioactivities. So far, there is scientific evidence available for analgesic, antiarthritic, antibacterial, anticancer, antidiabetic, antifungal, antiinflammatory, antioxidant, antipyretic, diuretic, antiurolithiatic, and nephroprotective activities and four bioactive compounds (cynarin, diacetyl, scopoletin, and tetritol) have been identified in this plant species. This work provides the basis for future researches involving this plant species.

Kaynakça

  • Angappan, R., Devanesan, A.A., Thilagar, S., 2018. Diuretic effect of chlorogenic acid from traditional medicinal plant Merremia emarginata (Burm. F.) and its by product hippuric acid. Clinical Phytoscience 4: 29. https://doi.org/10.1186/s40816-018-0088-5
  • Babu, A.V., Rao, R.S.C., Kumar, K.G., Babu, B.H., Satyanarayana, P.V.V., 2009. Biological activity of Merremia emarginata crude extracts in different solvents. Research Journal of Medicinal Plant 3: 134–140.
  • Babu, A.V., R.S.C.Rao, Babu, B.H., V.Subbaraju, G., 2013. Isolation and bioactivity of diacetyltetritol from Merremia emarginata (Burm.f). Natural Products: An Indian Journal 9: 201–208.
  • Baskar, A.A., Numair, K.S.A., Alsaif, M.A., Ignacimuthu, S., 2012. In vitro antioxidant and antiproliferative potential of medicinal plants used in traditional Indian medicine to treat cancer. Redox Report 17: 145–156. https://doi.org/10.1179/1351000212Y.0000000017
  • Devadasu, C., Naga Jyothi, N., Srinivasa Babu, P., Afzal Basha, S.K., 2017. Biological evaluation of Merremia emarginata for antibacterial, antifungal and antioxidant activities. World journal of Pharmacy and Pharmaceutical Sciences 6: 1509–1525.
  • Elumalai, E.K., Ramachandran, M., Thirumalai, T., Vinothkumar, P., 2011. Antibacterial activity of various leaf extracts of Merremia emarginata. Asian Pacific Journal of Tropical Biomedicine 1: 406–408. https://doi.org/10.1016/S2221-1691(11)60089-0
  • Gandhi, G.R., Sasikumar, P., 2012. Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine 2: 281–286. https://doi.org/10.1016/S2221-1691(12)60023-9
  • Indumathy, S., Gausunnisha, T., Rajalakshmi, R., Roselin, A., Thamizharasy, P., Arul Anand Raj, C.A., 2011. Anti-pyretic activity of ethanolic extract of Merremia emarginata (Burm. F) Hallier f. in rat. International Journal of Pharmaceutical Applications 2: 258–261.
  • Kamakshi, U.N., Rao, B.G., Rao, B.V., 2017. Comparison of in vitro antiurolithiatic activity of Aerva lanata, Sphaeranthus indicus, Merremia emarginata. Research Journal of Pharmacy and Technology 10: 1653. https://doi.org/10.5958/0974-360X.2017.00291.8
  • Kew Science, 2021. Merremia emarginata (Burm.f.) Hallier f. Available from: http://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:270513-1, Retrieved 27.05.2021.
  • Khare, C.P., 2007. Merremia emarginata (Burm.f.) Hallier f., in: Indian Medicinal Plants: An Illustrated Dictionary. Springer. New York. 335 p.
  • Parkavi, S., Ganesh, P., Swaminathan, C., 2020. Phytochemical analysis, antibacterial activity and antioxidant activity of leaf extracts of Merremia emarginata (Burm. f). International Journal of Pharmaceutical Sciences and Research 10: 5214–5218.
  • Prabhu, P., Sudev, S., Venkataraman, N., Shrikumar, D., 2019. In vitro antioxidant and antiarthritis activity of extracts and fractions of Merremia emarginata. Der Pharmacia Lettre 6: 227–231.
  • Prabhu, P.T., Pannerselvam, P., Selvakumari, S., Vijaykumar, R., Sivaraman, D., 2011. Effect of ethanolic and ethyl acetate extract of Merremia emarginata (Burm. f) in rheumatoid arthritis. International Research Journal of Pharmacy 3: 264–268.
  • Prabhu, T.P., Panneerselvam, P., Selvakumari, S., Ubaidulla, U., Shantha, A., 2012. Anticancer activity of Merremia emarginata (Burm. f) against human cervical and breast carcinoma. International Journal of Research and Development in Pharmacy and Life Sciences 1: 189–192.
  • Priya, P., Arul, C., Gausunnisha, T., Rajalakshmi, R., Roselin, A., Umarani, G., 2012. Study of analgesic activity of Merremia emarginata (BURM. F) Hallier F. International Journal of Pharmacy and Biological Sciences 2: 299–302.
  • Purushoth Prabhu, T., Panneerselvam, P., Vijaykumar, R., Clement Atlee, W., Balasubramanian, S., 2012. Antiinflammatory, anti-arthritis and analgesic effect of ethanolic extract of whole plant of Merremia emarginata Burm. f. Central European Journal of Biology 1: 94–99.
  • Rameshkumar, A., Sivasudha, T., Jeyadevi, R., Sangeetha, B., Ananth, D.A., Aseervatham, G.S.B., Nagarajan, N., Renganathan, R., Kathiravan, A., 2012. In vitro antioxidant and antimicrobial activities of Merremia emarginata using thioglycolic acid-capped cadmium telluride quantum dots. Colloids and Surfaces B: Biointerfaces 101: 74–82. https://doi.org/10.1016/j.colsurfb.2012.05.034
  • Rameshkumar, A., Sivasudha, T., Jeyadevi, R., Sangeetha, B., Aseervatham, G.S.B., Maheshwari, M., 2013. Profiling of phenolic compounds using UPLC–Q-TOF-MS/MS and nephroprotective activity of Indian green leafy vegetable Merremia emarginata (Burm. f.). Food Research International 50; 94–101.
  • Sathasivampillai, S., Rajamanoharan, P., Munday, M., Heinrich, M., 2017. Plants currently used to treat diabetes in Sri Lankan Siddha Medicine – an ethnobotanical survey in the Eastern Province: proceedings of the World Congress Integrative Medicine & Health 2017: Part three. Berlin. pp: 333.
  • Sathasivampillai, S.V., Rajamanoharan, P.R., Heinrich, M., Munday, M., 2015. Preparations and plants used to treat diabetes in Sri Lankan Siddha Medicine: proceedings of the 3rd International Conference on Ayurveda, Unani, Siddha and Traditional Medicine, Institute of Indigenous Medicine, University of Colombo. Colombo: pp. 67.
  • Sathasivampillai, S.V., Rajamanoharan, P.R.S., Heinrich, M., 2018. Siddha Medicine in Eastern Sri Lanka Today–Continuity and Change in the Treatment of Diabetes. Frontiers in Pharmacology 9: https://doi.org/10.3389/fphar.2018.01022
  • Sathasivampillai, S.V., Rajamanoharan, P.R.S., Munday, M., Heinrich, M., 2016. Plants used to treat diabetes in Sri Lankan Siddha Medicine – An ethnopharmacological review of historical and modern sources. Journal of Ethnopharmacology 198: 531–599. https://doi.org/10.1016/j.jep.2016.07.053

Merremia emarginata'nın (Burm.f.) biyoaktiviteleri Hallier f. özler ve izole edilmiş bileşikler

Yıl 2021, Cilt 3, Sayı 1, 110 - 119, 05.07.2021

Öz

Merremia emarginata (Burm.f.) Hallier f. Convolvulaceae familyasına ait yabani bir bitkidir. Çeşitli geleneksel ilaçlarda şeker hastalığı, epilepsi, romatizma, böbrek ve karaciğer rahatsızlıklarının tedavisinde kullanılır. Kafeik asit, rosmerik asit, skopoletin, tetritol ve vanillic asit gibi bileşikler, bu bitki türünün çeşitli kısımlarından izole edilmiştir. Bu kapsamlı inceleme çalışması, M. emarginata'yı içeren yayınlanmış çalışmalarla ilgili biyoaktiviteleri analiz etmeyi, özetlemeyi ve belgelemeyi amaçlamaktadır. PubMed, ScienceDirect, Scopus, Semantic Scholar ve Web of Science elektronik veritabanları, 1900'den Mayıs 2021'e kadar ilgili yayınlanmış makaleleri elde etmek için kullanıldı. Çeşitli biyoaktiviteler için in vivo ve in vitro bilimsel kanıtlar şu anda mevcuttur. Şimdiye kadar, analjezik, antiartritik, antibakteriyel, antikanser, antidiyabetik, antifungal, antiinflamatuar, antioksidan, antipiretik, diüretik, antiörolitik ve nefroprotektif aktivitelere ilişkin bilimsel kanıtlar mevcuttur ve dört biyoaktif bileşik (sinarin, diasetil, skopoletin ve tetritol) bulunmaktadır. bu bitki türlerinde tespit edilmiştir. Bu çalışma, bu bitki türlerini içeren gelecekteki araştırmalar için temel oluşturmaktadır.

Kaynakça

  • Angappan, R., Devanesan, A.A., Thilagar, S., 2018. Diuretic effect of chlorogenic acid from traditional medicinal plant Merremia emarginata (Burm. F.) and its by product hippuric acid. Clinical Phytoscience 4: 29. https://doi.org/10.1186/s40816-018-0088-5
  • Babu, A.V., Rao, R.S.C., Kumar, K.G., Babu, B.H., Satyanarayana, P.V.V., 2009. Biological activity of Merremia emarginata crude extracts in different solvents. Research Journal of Medicinal Plant 3: 134–140.
  • Babu, A.V., R.S.C.Rao, Babu, B.H., V.Subbaraju, G., 2013. Isolation and bioactivity of diacetyltetritol from Merremia emarginata (Burm.f). Natural Products: An Indian Journal 9: 201–208.
  • Baskar, A.A., Numair, K.S.A., Alsaif, M.A., Ignacimuthu, S., 2012. In vitro antioxidant and antiproliferative potential of medicinal plants used in traditional Indian medicine to treat cancer. Redox Report 17: 145–156. https://doi.org/10.1179/1351000212Y.0000000017
  • Devadasu, C., Naga Jyothi, N., Srinivasa Babu, P., Afzal Basha, S.K., 2017. Biological evaluation of Merremia emarginata for antibacterial, antifungal and antioxidant activities. World journal of Pharmacy and Pharmaceutical Sciences 6: 1509–1525.
  • Elumalai, E.K., Ramachandran, M., Thirumalai, T., Vinothkumar, P., 2011. Antibacterial activity of various leaf extracts of Merremia emarginata. Asian Pacific Journal of Tropical Biomedicine 1: 406–408. https://doi.org/10.1016/S2221-1691(11)60089-0
  • Gandhi, G.R., Sasikumar, P., 2012. Antidiabetic effect of Merremia emarginata Burm. F. in streptozotocin induced diabetic rats. Asian Pacific Journal of Tropical Biomedicine 2: 281–286. https://doi.org/10.1016/S2221-1691(12)60023-9
  • Indumathy, S., Gausunnisha, T., Rajalakshmi, R., Roselin, A., Thamizharasy, P., Arul Anand Raj, C.A., 2011. Anti-pyretic activity of ethanolic extract of Merremia emarginata (Burm. F) Hallier f. in rat. International Journal of Pharmaceutical Applications 2: 258–261.
  • Kamakshi, U.N., Rao, B.G., Rao, B.V., 2017. Comparison of in vitro antiurolithiatic activity of Aerva lanata, Sphaeranthus indicus, Merremia emarginata. Research Journal of Pharmacy and Technology 10: 1653. https://doi.org/10.5958/0974-360X.2017.00291.8
  • Kew Science, 2021. Merremia emarginata (Burm.f.) Hallier f. Available from: http://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:270513-1, Retrieved 27.05.2021.
  • Khare, C.P., 2007. Merremia emarginata (Burm.f.) Hallier f., in: Indian Medicinal Plants: An Illustrated Dictionary. Springer. New York. 335 p.
  • Parkavi, S., Ganesh, P., Swaminathan, C., 2020. Phytochemical analysis, antibacterial activity and antioxidant activity of leaf extracts of Merremia emarginata (Burm. f). International Journal of Pharmaceutical Sciences and Research 10: 5214–5218.
  • Prabhu, P., Sudev, S., Venkataraman, N., Shrikumar, D., 2019. In vitro antioxidant and antiarthritis activity of extracts and fractions of Merremia emarginata. Der Pharmacia Lettre 6: 227–231.
  • Prabhu, P.T., Pannerselvam, P., Selvakumari, S., Vijaykumar, R., Sivaraman, D., 2011. Effect of ethanolic and ethyl acetate extract of Merremia emarginata (Burm. f) in rheumatoid arthritis. International Research Journal of Pharmacy 3: 264–268.
  • Prabhu, T.P., Panneerselvam, P., Selvakumari, S., Ubaidulla, U., Shantha, A., 2012. Anticancer activity of Merremia emarginata (Burm. f) against human cervical and breast carcinoma. International Journal of Research and Development in Pharmacy and Life Sciences 1: 189–192.
  • Priya, P., Arul, C., Gausunnisha, T., Rajalakshmi, R., Roselin, A., Umarani, G., 2012. Study of analgesic activity of Merremia emarginata (BURM. F) Hallier F. International Journal of Pharmacy and Biological Sciences 2: 299–302.
  • Purushoth Prabhu, T., Panneerselvam, P., Vijaykumar, R., Clement Atlee, W., Balasubramanian, S., 2012. Antiinflammatory, anti-arthritis and analgesic effect of ethanolic extract of whole plant of Merremia emarginata Burm. f. Central European Journal of Biology 1: 94–99.
  • Rameshkumar, A., Sivasudha, T., Jeyadevi, R., Sangeetha, B., Ananth, D.A., Aseervatham, G.S.B., Nagarajan, N., Renganathan, R., Kathiravan, A., 2012. In vitro antioxidant and antimicrobial activities of Merremia emarginata using thioglycolic acid-capped cadmium telluride quantum dots. Colloids and Surfaces B: Biointerfaces 101: 74–82. https://doi.org/10.1016/j.colsurfb.2012.05.034
  • Rameshkumar, A., Sivasudha, T., Jeyadevi, R., Sangeetha, B., Aseervatham, G.S.B., Maheshwari, M., 2013. Profiling of phenolic compounds using UPLC–Q-TOF-MS/MS and nephroprotective activity of Indian green leafy vegetable Merremia emarginata (Burm. f.). Food Research International 50; 94–101.
  • Sathasivampillai, S., Rajamanoharan, P., Munday, M., Heinrich, M., 2017. Plants currently used to treat diabetes in Sri Lankan Siddha Medicine – an ethnobotanical survey in the Eastern Province: proceedings of the World Congress Integrative Medicine & Health 2017: Part three. Berlin. pp: 333.
  • Sathasivampillai, S.V., Rajamanoharan, P.R., Heinrich, M., Munday, M., 2015. Preparations and plants used to treat diabetes in Sri Lankan Siddha Medicine: proceedings of the 3rd International Conference on Ayurveda, Unani, Siddha and Traditional Medicine, Institute of Indigenous Medicine, University of Colombo. Colombo: pp. 67.
  • Sathasivampillai, S.V., Rajamanoharan, P.R.S., Heinrich, M., 2018. Siddha Medicine in Eastern Sri Lanka Today–Continuity and Change in the Treatment of Diabetes. Frontiers in Pharmacology 9: https://doi.org/10.3389/fphar.2018.01022
  • Sathasivampillai, S.V., Rajamanoharan, P.R.S., Munday, M., Heinrich, M., 2016. Plants used to treat diabetes in Sri Lankan Siddha Medicine – An ethnopharmacological review of historical and modern sources. Journal of Ethnopharmacology 198: 531–599. https://doi.org/10.1016/j.jep.2016.07.053

Ayrıntılar

Birincil Dil İngilizce
Konular Fizik, Atomik ve Moleküler Kimya, Kimya, Analitik, Kimya, Organik, Kimya, Ortak Disiplinler
Bölüm Derleme
Yazarlar

Saravanan VİVEKANANDARAJAH SATHASİVAMPİLLAİ (Sorumlu Yazar)
KnowledgeLink Group, Inc., Waltham, MA 02451, USA
0000-0002-5938-0509
Sri Lanka


Pholtan Rajeev SEBASTİAN
Provincial Herbal Garden Management Center, Trincomalee, Sri Lanka
0000-0001-9341-5843
Sri Lanka

Destekleyen Kurum Not Applicable
Proje Numarası Not Applicable
Teşekkür The authors are grateful to their family members for their support to deliver this work.
Yayımlanma Tarihi 5 Temmuz 2021
Başvuru Tarihi 28 Mayıs 2021
Kabul Tarihi 24 Haziran 2021
Yayınlandığı Sayı Yıl 2021, Cilt 3, Sayı 1

Kaynak Göster

APA Vivekanandarajah Sathasivampillai, S. & Sebastian, P. R. (2021). Bioactivities of Merremia emarginata (Burm.f.) Hallier f. extracts and isolated compounds . Journal of Spectroscopy and Molecular Sciences , 3 (1) , 110-119 . Retrieved from https://dergipark.org.tr/tr/pub/jsms/issue/63598/944077

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