Preeklamptik gebelerde maternal kan, kordon kanı ve plasental dokuda Malondialdehit düzeylerinin fetomaternal Doppler değerleri ile korelasyonu

Öz

Amaç Bu çalışmada preeklamptik gebelerde maternal kan, fetal kan ve plasental yataktaki malondialdehit (MDA) düzeylerinin fetomaternal Doppler değerleri ile korelasyonunun değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem Çalışma 52 sağlıklı, 22 preeklamptik gebe olmak üzere toplam 74 olgu ile yürütülmüştür. Gebelerin maternal kan, kordon kanı, plasenta dokularında MDA düzeyleri ölçüldü. Uterin ve umbilikal arterlerde Doppler sonografik ölçümler yapıldı. Preeklamptik ve sağlıklı gebelerin Doppler değerleri ile MDA düzeyleri karşılaştırıldı. Veriler SPSS programında analiz edildi. İstatistiksel anlamlılık düzeyi p<0.05 kabul edildi. Bulgular Preeklamptik gebelerde maternal kan ve plasental dokudaki MDA seviyeleri, sağlıklı gebelere göre anlamlı şekilde yüksekti (p<0.05). Umbilikal arter ve umbilikal ven MDA düzeyleri çalışma grubunda, kontrol grubuna göre daha yüksek bulunsa da istatistiksel olarak anlamlı değildi (p>0.05). Umbilikal arter ve uterin arterlerdeki Doppler sonografik indeksler, preeklamptik grupta kontrol grubuna göre anlamlı şekilde daha yüksekti (p<0.05). Tüm hastalar değerlendirildiğinde maternal ve plasental malondialdehit değerleri ile umbilikal ve uterin arter Doppler değerleri arasında anlamlı bir korelasyon saptanmadı. Sonuç Preeklamptik gebelerde, kan ve plasental dokudaki MDA düzeyleri ve fetomaternal Doppler değerleri kontrol grubuna göre anlamlı şekilde daha yüksek bulunmuş, ancak MDA düzeyleri ile Doppler değerleri arasında anlamlı bir korelasyon saptanmamıştır.

Anahtar Kelimeler

• Oksidatif stres
• lipid peroksidasyonu
• malondialdehit
• Doppler sonografi
• plasental yetmezlik
• preeklampsi

Correlation of maternal blood, cord blood and placental tissue malondialdehyde levels with fetomaternal Doppler values in preeclamptic pregnant women

Öz

Aim In this study, it was aimed to evaluate the correlation of malondialdehyde (MDA) levels in maternal blood, fetal blood and placental bed with fetomaternal Doppler values in preeclamptic pregnant women. Material and Methods The study was carried out with a total of 74 cases, 52 of whom were healthy and 22 were pregnant with preeclampsia.MDA levels were measured in maternal blood, cord blood and placenta tissues of the pregnant women. Doppler sonographic measurements were made in the uterine and umbilical arteries. Doppler values and MDA levels of preeclamptic and healthy pregnant women were compared. Results MDA levels in maternal blood and placental tissue in preeclamptic pregnant women were significantly higher than healthy pregnant women (p<0.05).Although umbilical artery and umbilical vein MDA levels were higher in the study group than in the control group, they were not statistically significant (p>0.05). Doppler sonographic indexes in the umbilical and uterine arteries were significantly higher in the preeclamptic group than in the control group (p<0.05). When all patients were evaluated, there was no significant correlation between maternal and placental malondialdehyde values and umbilical and uterine artery Doppler values. Conclusion MDA levels and fetomaternal Doppler values in blood and placental tissue were significantly higher in preeclamptic pregnants compared to the control group. However, no significant correlation was found between MDA levels and Doppler values.

Anahtar Kelimeler

• Oxidative stress
• lipid peroxidation
• malondialdehyde
• Doppler sonography
• placental insufficiency
• preeclampsia
• Oksidatif stres
• lipid peroksidasyonu
• malondialdehit
• Doppler sonografi
• plasental yetmezlik
• preeklampsi

Kaynakça

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