Yıl 2020, Cilt 4 , Sayı 4, Sayfalar 255 - 262 2020-11-07

EFFECT OF FTO rs9939609 POLIMORPHISM ON OBESITY IN TURKISH POPULATION

Meliha Merve HIZ ÇİÇEKLİYURT [1] , Sevilay OĞUZ KILIÇ [2] , Levent ELMAS [3]


Obesity is a disease that is affected by environmental conditions as well as genetic predisposition. This is a case-control study that aimed to investigate the relationship between FTO rs9939609 polymorphism and obesity. The relation between the rs9939609 polymorphism and obesity in 80 ower-weight (BMI 30) and 131 under/normal weight (BMI 30) subjects was examined. The allele and genotype frequencies of each group were determined by the allele counting method. The relationship between single nucleotide exchange and obesity risk was calculated using the odds ratio. Statistical analyzes were performed with SPSS 18.0. Results: The frequency of T allele was 0.58 and 0.45 respectively in the healthy and overweight group when allele frequencies of both groups were compared. The change in allele frequency increased the obesity rate by 1.8 fold. The rs99399609 polymorphism increases obesity risk by2.7 fold in the homozygotes model. Conclusions: In this research, we found statistically significant results in allele frequency difference and allele positivity. The relationship between rs9939609 polymorphism and obesity will be highlighted by larger population studies.
Adiposity, FTO, rs9939609, BMI, Body composition
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Birincil Dil en
Konular Tıp
Bölüm Health Sciences
Yazarlar

Orcid: 0000-0003-4303-9717
Yazar: Meliha Merve HIZ ÇİÇEKLİYURT
Kurum: CANAKKALE ONSEKIZ MART UNIVERSITY
Ülke: Turkey


Orcid: 0000-0003-3560-849X
Yazar: Sevilay OĞUZ KILIÇ
Kurum: CANAKKALE ONSEKIZ MART UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-6865-6466
Yazar: Levent ELMAS
Kurum: IZMIR BAKIRCAY UNIVERSITY
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 7 Kasım 2020

APA Hız Çi̇çekli̇yurt, M , Oğuz Kılıç, S , Elmas, L . (2020). EFFECT OF FTO rs9939609 POLIMORPHISM ON OBESITY IN TURKISH POPULATION . Journal of Scientific Perspectives , 4 (4) , 255-262 . DOI: 10.26900/jsp.4.022