Impact of the variations in the temperature on the first spike latency of a Hodgkin-Huxley neuron model

Yıl 2013, Cilt: 3 Sayı: 1 , 26 - 29 , 01.01.2013

Mahmut Özer Rukiye Uzun

https://izlik.org/JA65BS23XY

Öz

For stimuli just beyond threshold and certain noise strength, the Hodgkin–Huxley HH neuron model shows sensitivity to noise with respect to latency to first spike after stimulus onset. This effect has been called “noise delayed decay” NDD . Here we investigate how the NDD is affected by the variation in temperature using a HH model that includes stochastic ion channels. We show that the NDD effect increases and emerges for smaller noise strengths or larger cell sizes as the temperature increases. We also show that the potassium channel noise plays a key role on the appearance of the NDD effect.

Anahtar Kelimeler

First spike , Temperature effect , Hodgkin-Huxley neuron model.

Kaynakça

• Abeles, M. 1991. Corticonics: Neural Circuitry of the Cerebral Cortex, Cambridge: Cambridge University Press.
• Abeles, M., Bergman, H., Magalit, E., Vaadia, E. 1999. Spatio temporal firing patterns in the frontal cortex of behaving monkeys, J. Neurophysiol. 70, 1629-1638.
• Adrian, ED. 1926. The impulses produced by sensory nerve endings, J. Physiol. (Lond.), 61: 49-72.
• Bezanilla, F, Taylor, RE. 1978. Temperature effects on gating currents in the squid giant axon. Biophys J. 479–484.
• de Ruyter van Steveninck, R., Bialek, W. 1988. Real-time performance of a movement sensitive neuron in the blowfly visual system: coding and information transfer in short spike sequences. Proc. R. Soc. London Ser. B 234:379–414.
• Feng, J., Tuckwell, HC. 2003. Optimal control of neuronal activity. Phys. Rev. Lett., 91(1): 018101-4.
• Fox, RF. 1997. Stochastic versions of the Hodgkin–Huxley equations. J. Biophys., 72: 2068–2074.
• Hallett, M. 2007. Transcranial magnetic stimulation: A Primer, Neuron 55(2): 187-199.
• Hodgkin, AL. 1959. Ion movements during nerve activity. Ann. New York Acad. Sci.81:221-246.