Potasyum İyon Kanal Bloklama ile Öz-Sinaptik Hodgkin-Huxley Nöronunun Ateşleme Aktivitesinin Kontrolü

Yıl 2017, Cilt: 7 Sayı: 2, 558 - 562, 01.06.2017

Rukiye Uzun

Öz

Öz-sinaptik bağlantıya sahip bir Hodgkin-Huxley nöronunun ateşleme davranışı, bloke edilmiş potasyum iyon kanallarının ayarlanmasıyla araştırılmıştır. Kuplaj şiddeti ve iletim gecikmesiyle tanımlanan bir elektriksel özsinaps durumu ele alınmıştır. Orta öz-sinapstik iletkenlik seviyesinde öz-sinaptik zaman gecikmesine bağlı olarak bir çift koherans rezonansının oluştuğu ve yanı sıra potasyum iyon kanallarını bloke etmenin bu davranışı özsinaptik zaman gecikmesinin belirli bir aralığında belirli bir ölçüde bozduğu gösterilmiştir. Elde edilen sonuçlar ışığında; aktif potasyum iyon kanallarının sayısındaki azalmanın, elektriksel öz-sinaptik bağlantı olması durumunda nöronun ateşleme davranışını bozduğu sonucuna ulaşılmıştır

Anahtar Kelimeler

Öz-sinaps, Hodgkin-Huxley nöron, Potasyum iyon kanal bloklama, ateşleme davranışı

Controlling the Spiking Activity of Autaptic Hodgkin-Huxley Neuron by Potassium Ion Channel Blocking

Öz

We investigated the spiking activity of autaptic Hodgkin-Huxley neuron with a tunable fraction of blocked potassium ion channels. We consider an electrical autapse expressed by its coupling strength and delay time. We showed that there exists a double coherence resonance induced by autaptic time delay at an intermediate autaptic conductance level, as well potassium ion channel blocking impairs this behavior at a certain extent at a specific range of autaptic time delay. In the light of the obtained results; we concluded that the reduction of the number of active potassium ion channels destroys the spiking regularity of a single neuron in the presence of electrical autapse.

Anahtar Kelimeler

Autapse, Potassium ion channel blocking, Spiking activity, Hodgkin-Huxley neuron.

Kaynakça

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