Anti-Kanser Aktiviteye Sahip Bileşikler Olarak Flor-Sübstitüe Kalkonlar

Yıl 2017, Cilt: 7 Sayı: 2, 658 - 664, 01.06.2017

Serdar Burmaoğlu

Öz

Kalkonlar iki aromatik halkanın üç karbonla birbirine bağlandığı ve düz zincirinde α, β-doymamış bir karbonil veya doymuş bir karbonil grubu olan açık zincirli flavonoidlerdir. Kalkonlar basit kimyaya sahip ve kolaylıkla türevlendirilebilen önemli bileşiklerdir. Son yıllarda yapılarında flor atomu ihtiva eden potansiyel ilaç adayı olabilecek kalkonlar oldukça yaygın hale gelmiştir. Flor atomunun biyolojik olarak aktif bir molekülün yapısında yer alması minimum sterik etki göstermesine sebep olduğu ve enzimlerin aktif bölgeleri ve diğer biyolojik sistemlerle etkileşimi kolaylaştırdığı bildirilmektedir. Bu mini derleme, flor-sübstitüe kalkonların potansiyel antikanser etkili ilaç geliştirme çalışmalarındaki son gelişmelerin derlenmesini amaçlamaktadır

Anahtar Kelimeler

Antikanser aktivite, Flor, Kalkon

Fluoro-Substituted Chalcones as the Compounds Having Anticancer Activity

Öz

Chalcones consist of open chain flavonoids in which the two aromatic rings are linked by three carbons and have and/or α,β-unsaturated, saturated carbonyl systems in their open chains. Chalcones are important compounds with simple chemistry that have easy synthetic access to yield various substituted derivatives. In recent years the number chalcones as potential lead drugs containing fluorine in their structures have become quite common. It has been reported that insertion of a fluorine atom into a biologically active compound results in minimum steric changes and eases the interactions between the enzymes active site and other biological systems. This mini review intends the most recent updates on anticancer potential of fluoro-substituted chalcones.

Anahtar Kelimeler

Chalcone, fluorine, anticancer activity.

Kaynakça

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