Development of a Ribavirin Selective Potentiometric PVC-Membrane Microsensor based on Ribavirin Imprinted Polymer
Öz
In this study, a molecularly imprinted polymer
(MIP) of ribavirin, which is an antiviral active drug, was synthesized by suspension
polymerization and on the basis of the synthesized polymer, ribavirin selective
potentiometric microsensor was constructed. Potentiometric performance
characteristics of the microsensor was investigated. It was determined that the
sensor membrane at the ratio of 4% MIP, 67% nitrophenyloctylether and 29% polyvinyl
chloride performed the best potentiometric performance characteristics. For
this sensor; linear range, slope, detection limit and response time were
determined as 1×10-5-1.0×10-2 M, 29.8 mV/decade, 8,7×10-6
M, and ~ 10 s, respectively. Potentiometric determinations of ribavirin
in commercial drug samples were successfully performed by using ribavirin
selective microsensor.
Anahtar Kelimeler
Molecular imprinting,Ribavirin,Ion selective sensor,Potentiometry
Kaynakça
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