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The Effect of Pump on Early Postoperative Mortality and Cerebrovascular Accident in Coronary Bypass Surgery Patients

Yıl 2018, Cilt: 21 Sayı: 1, 9 - 15, 01.04.2018

Öz

Introduction:
This
study investigated the mortality rates during the postoperative early period
(one month) in patients who underwent on- or off-pump coronary artery bypass
grafting (CABG) and explored the effects of cardiopulmonary bypass (CPB) on
early mortality and cerebral accident.



Patients
and Methods:
This study comprises a total of 260 subjects that
underwent CABG surgery in our clinic. Patients who underwent CABG were grouped
according to two different surgical techniques: the first group (Group 1)
consisted of patients who underwent CABG using CPB and cross-clamp (on-pump);
the second group (Group 2) consisted of patients who underwent CABG by beating
heart (off-pump) technique. Proximal anastomoses were performed using side
clamps in all cases.



Results: Postoperative
follow-up was conducted on patients until Day 30 for mortality. We encountered
four dead cases and six cerebrovascular accidents.



Conclusion: The rates of cerebral
accidents (2.4% vs. 2.1%) and deaths (1.8% vs. 1%) have the same ratios and are
not statistically significant in on-pump CABG surgeries compared with off-pump
CABG surgeries.

Kaynakça

  • 1. Beckermann J, Van Camp J, Li S, Wahl SK, Collins A, Herzog CA. On-pump versus off-pump coronary surgery outcomes in patients requiring dialysis: perspectives from a single center and the United States experience. J Thorac Cardiovasc Surg 2006;131:1261-6.
  • 2. Diegeler A, Hirsch R, Schneider F, Schilling LO, Falk V, Rauch T, et al. Neuromonitoring and neurocognitive outcome in off-pump versus conventional coronary bypass operation. Ann Thorac Surg 2000;69:1162-6.
  • 3. Bucerius J, Gummert JF, Walther T, Schmitt DV, Doll N, Falk V, et al. On-pump versus off-pump coronary artery bypass grafting: impact on postoperative renal failure requiring renal replacement therapy. Ann Thorac Surg 2004;77:1250-6.
  • 4. Puskas J, Williams W, Duke P, Staples JR, Glas KE, Marshall JJ, et al. Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay: a prospective randomized comparison of two hundred unselected patients undergoing off-pump versus conventional coronary artery bypass grafting. J Thorac Cardiovasc Surg 2003;125:797-808.
  • 5. Mack M, Bachand D, Acuff T, Edgerton J, Prince S, Dewey T, et al. Improved outcomes in coronary artery bypass grafting with beating-heart techniques. J Thorac Cardiovasc Surg 2002;124:598-607.
  • 6. Reiner Z, Catapano AL, Backer GD, Backer GD, Grahem I, Taskinen MR, et al. The Task for the management of dyslipidaemias of th European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J 2011;32:1769-818.
  • 7. Salis S, Mazzanti VV, Merli G, Salvi L, Tedesco CC, Veglia F, et al. Cardiopulmonary bypass duration is an indipendent predictor of morbidity and mortality after cardiac surgery. J Cardiothorac Vasc Anesth 2008;22:814-22.
  • 8. Puskas JD, Williams WH, Mahoney EM, Huber PR, Block PC, Duke PG, et al. Off-pump vs conventional coronary artery bypass grafting: early and 1-year graft patency, cost, and quality-of-life outcomes. JAMA 2004;291:1841-9.
  • 9. Williams ML, Muhlbaier LH, Schroder JN, Hata JA, Peterson ED, Smith PK, et al. Risk-adjusted short-and long-term outcomes for on-pump versus off-pump coronary artery bypass surgery. Circulation 2005;112(Suppl 9): s366-70.
  • 10. Raja SG, Husain M, Popescu FL, Chudasama D, Daley S, Amrani M. Does off-pump coronary artery bypass grafting negatively impact long-term survival and freedom from reintervention? Biomed Res Int 2013:602871.
  • 11. Dalen M, Ivert T, Holzmann MJ, Sartipy U. Long-term survival after off-pump coronary artery bypass surgery: a Swedish nationwide cohort study. Ann Thorac Surg 2013;96:2054-60.
  • 12. Hueb W, Lopes NH, Pereira AC, Hueb AC, Soares PR, Favarato D, et al. Five-year follow-up of a randomized comparison between off-pump and on-pump stable multivessel coronary artery bypass grafting. The MASS III Trial. Circulation 2010;122(Suppl 11):s48-52.
  • 13. Lemma MG, Coscioni E, Tritto FP, Centofanti P, Fondacone C, Salica A, et al. On-pump versus off-pump coronary artery bypass surgery in high-risk patients: operative results of a prospective randomized trial (on-off study). J Thorac Cardiovasc Surg 2012;143:625-31.
  • 14. Barandon L, Richebé P, Munos E, Calderon J, Lafitte M, Couffinhal T, et al. Off-pump coronary artery bypass surgery in very high-risk patients: adjustment and preliminary results. Interact Cardiovasc Thorac Surg 2008;7:789-93.
  • 15. Marui A, Okabayashi H, Komiya T, Tanaka S, Furukawa Y, Kita T, et al. Benefits of off-pump coronary artery bypass grafting in high-risk patients. Circulation 2012;126(Suppl 11):s151-7.
  • 16. Vasques F, Rainio A, Heikkinen J, Mikkola R, Lahtinen J, Kettunen U, et al. Off-pump versus onpump coronary artery bypass surgery in patients aged 80 years and older: institutional results and meta-analysis. Heart Vessels 2013;28:46-56.
  • 17. Mack MJ, Pfister A, Bachand D, Emery R, Magee MJ, Connolly M, et al. Comparison of coronary bypass surgery with and without cardiopulmonary bypass in patients with multivessel disease. J Thorac Cardiovasc Surg 2004;127:167-73.
  • 18. Zangrillo A, Crescenzi G, Landoni G, Leoni A, Marino G, Calabro MG, et al. Off-pump coronary artery bypass grafting reduces postoperative neurologic complications. J Cardiothorac Vasc Anesth 2005;19:193-6.
  • 19. Farrokhyar F, Wang X, Kent R, Lamy A. Early mortality from off-pump and on-pump coronary bypass surgery in Canada: a comparison of the STS and the EuroSCORE risk prediction algorithms. Can J Cardiol 2007;23:879-83.
  • 20. Racz MJ, Hannan EL, Isom OW, Subramanian VA, Jones RH, Gold JP, et al. A comparison of short- and long-term outcomes after off-pump and on-pump coronary artery bypass graft surgery with sternotomy. J Am Coll Cardiol 2004;43:557-64.
  • 21. Gobran SR, Goldman S, Ferdinand F, Wertan MA, Trace C, Grunkemeier GL, et al. Outcomes after usage of a quality initiative program for off-pump coronary artery bypass surgery: a comparison with on-pump surgery. Ann Thorac Surg 2004;78:2015-21.
  • 22. Polomsky M, Puskas JD. Off-pump coronary artery bypass grafting--the current state. Circ J 2012;76:784-90.
  • 23. Selnes OA, Grega MA, Bailey MM, Pham LD, Zeger SL, Baumgartner WA, et al. Do management strategies for coronary artery disease influence 6-year cognitive outcomes? Ann Thorac Surg 2009;88:445-54.
  • 24. Van Dijk D, Spoor M, Hijman R, Nathoe HM, Borst C, Jansen EW, et al. Cognitive and cardiac outcomes 5 years after off-pump vs on-pump coronary artery bypass graft surgery. JAMA 2007;297:701-8.
  • 25. Van Dijk D, Nierich AP, Jansen EW, Nathoe HM, Suyker WJ, Diephuis JC, et al. Early outcome after off-pump versus on-pump coronary bypass surgery. Circulation 2001;104:1761-6.
  • 26. Plomondon ME, Cleveland JC Jr, Ludwig ST, Grunwald GK, Kiefe CI, Grover FL, et al. Off-pump coronary artery bypass is associated with improved risk-adjusted outcomes. Ann Thorac Surg 2001;72:114-9.

Açık Kalp Cerrahisinde, Pompanın Erken Postoperatif Mortalite ve Serebrovasküler Olay Üzerine Etkisi

Yıl 2018, Cilt: 21 Sayı: 1, 9 - 15, 01.04.2018

Öz

Giriş: Bu çalışma, son gelişmelerle pompalı/pompasız koroner arter baypas grafting
(KABGO) uygulanan hastalarda, postoperatif erken dönemde (bir ayda), kardiyopulmoner
baypas (KPB)'ın erken mortalite ve serebral olay üzerine etkileri araştırıldı.



Hastalar ve
Yöntem:
Çalışmamız, kliniğimizde koroner arter baypas greftleme
ameliyatı yapılan toplam 260 olguyu içermektedir. KABGO uygulanan hastalar iki
farklı cerrahi tekniğe göre gruplandırıldı. Birinci grup (Grup 1), CPB ve X
klemp (on-pump) kullanılarak KABGO uygulanan hastalardan oluştu. İkinci grup
(Grup 2), atan kalp (off-pump) tekniği ile KABGO uygulanan hastalardan oluştu.
Proksimal anastomozlar tüm olgularda yan klemp kullanılarak yapıldı.



Bulgular: Hastalar postoperatif otuzuncu güne kadar mortalite açısından takip edildi.
Dört ölüm olgusu ve altı serebrovasküler olayla karşı karşıya kaldık.



Sonuç: On-pump KABGO
ameliyatlarında off-pump KABGO ameliyatlarına kıyasla serebral kaza oranları
(%2.4’e karşı %2.1) ve ölüm (%1’e karşı %1.8) benzer oranda görülürken
istatistiksel olarak anlamlı değildir.

Kaynakça

  • 1. Beckermann J, Van Camp J, Li S, Wahl SK, Collins A, Herzog CA. On-pump versus off-pump coronary surgery outcomes in patients requiring dialysis: perspectives from a single center and the United States experience. J Thorac Cardiovasc Surg 2006;131:1261-6.
  • 2. Diegeler A, Hirsch R, Schneider F, Schilling LO, Falk V, Rauch T, et al. Neuromonitoring and neurocognitive outcome in off-pump versus conventional coronary bypass operation. Ann Thorac Surg 2000;69:1162-6.
  • 3. Bucerius J, Gummert JF, Walther T, Schmitt DV, Doll N, Falk V, et al. On-pump versus off-pump coronary artery bypass grafting: impact on postoperative renal failure requiring renal replacement therapy. Ann Thorac Surg 2004;77:1250-6.
  • 4. Puskas J, Williams W, Duke P, Staples JR, Glas KE, Marshall JJ, et al. Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay: a prospective randomized comparison of two hundred unselected patients undergoing off-pump versus conventional coronary artery bypass grafting. J Thorac Cardiovasc Surg 2003;125:797-808.
  • 5. Mack M, Bachand D, Acuff T, Edgerton J, Prince S, Dewey T, et al. Improved outcomes in coronary artery bypass grafting with beating-heart techniques. J Thorac Cardiovasc Surg 2002;124:598-607.
  • 6. Reiner Z, Catapano AL, Backer GD, Backer GD, Grahem I, Taskinen MR, et al. The Task for the management of dyslipidaemias of th European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J 2011;32:1769-818.
  • 7. Salis S, Mazzanti VV, Merli G, Salvi L, Tedesco CC, Veglia F, et al. Cardiopulmonary bypass duration is an indipendent predictor of morbidity and mortality after cardiac surgery. J Cardiothorac Vasc Anesth 2008;22:814-22.
  • 8. Puskas JD, Williams WH, Mahoney EM, Huber PR, Block PC, Duke PG, et al. Off-pump vs conventional coronary artery bypass grafting: early and 1-year graft patency, cost, and quality-of-life outcomes. JAMA 2004;291:1841-9.
  • 9. Williams ML, Muhlbaier LH, Schroder JN, Hata JA, Peterson ED, Smith PK, et al. Risk-adjusted short-and long-term outcomes for on-pump versus off-pump coronary artery bypass surgery. Circulation 2005;112(Suppl 9): s366-70.
  • 10. Raja SG, Husain M, Popescu FL, Chudasama D, Daley S, Amrani M. Does off-pump coronary artery bypass grafting negatively impact long-term survival and freedom from reintervention? Biomed Res Int 2013:602871.
  • 11. Dalen M, Ivert T, Holzmann MJ, Sartipy U. Long-term survival after off-pump coronary artery bypass surgery: a Swedish nationwide cohort study. Ann Thorac Surg 2013;96:2054-60.
  • 12. Hueb W, Lopes NH, Pereira AC, Hueb AC, Soares PR, Favarato D, et al. Five-year follow-up of a randomized comparison between off-pump and on-pump stable multivessel coronary artery bypass grafting. The MASS III Trial. Circulation 2010;122(Suppl 11):s48-52.
  • 13. Lemma MG, Coscioni E, Tritto FP, Centofanti P, Fondacone C, Salica A, et al. On-pump versus off-pump coronary artery bypass surgery in high-risk patients: operative results of a prospective randomized trial (on-off study). J Thorac Cardiovasc Surg 2012;143:625-31.
  • 14. Barandon L, Richebé P, Munos E, Calderon J, Lafitte M, Couffinhal T, et al. Off-pump coronary artery bypass surgery in very high-risk patients: adjustment and preliminary results. Interact Cardiovasc Thorac Surg 2008;7:789-93.
  • 15. Marui A, Okabayashi H, Komiya T, Tanaka S, Furukawa Y, Kita T, et al. Benefits of off-pump coronary artery bypass grafting in high-risk patients. Circulation 2012;126(Suppl 11):s151-7.
  • 16. Vasques F, Rainio A, Heikkinen J, Mikkola R, Lahtinen J, Kettunen U, et al. Off-pump versus onpump coronary artery bypass surgery in patients aged 80 years and older: institutional results and meta-analysis. Heart Vessels 2013;28:46-56.
  • 17. Mack MJ, Pfister A, Bachand D, Emery R, Magee MJ, Connolly M, et al. Comparison of coronary bypass surgery with and without cardiopulmonary bypass in patients with multivessel disease. J Thorac Cardiovasc Surg 2004;127:167-73.
  • 18. Zangrillo A, Crescenzi G, Landoni G, Leoni A, Marino G, Calabro MG, et al. Off-pump coronary artery bypass grafting reduces postoperative neurologic complications. J Cardiothorac Vasc Anesth 2005;19:193-6.
  • 19. Farrokhyar F, Wang X, Kent R, Lamy A. Early mortality from off-pump and on-pump coronary bypass surgery in Canada: a comparison of the STS and the EuroSCORE risk prediction algorithms. Can J Cardiol 2007;23:879-83.
  • 20. Racz MJ, Hannan EL, Isom OW, Subramanian VA, Jones RH, Gold JP, et al. A comparison of short- and long-term outcomes after off-pump and on-pump coronary artery bypass graft surgery with sternotomy. J Am Coll Cardiol 2004;43:557-64.
  • 21. Gobran SR, Goldman S, Ferdinand F, Wertan MA, Trace C, Grunkemeier GL, et al. Outcomes after usage of a quality initiative program for off-pump coronary artery bypass surgery: a comparison with on-pump surgery. Ann Thorac Surg 2004;78:2015-21.
  • 22. Polomsky M, Puskas JD. Off-pump coronary artery bypass grafting--the current state. Circ J 2012;76:784-90.
  • 23. Selnes OA, Grega MA, Bailey MM, Pham LD, Zeger SL, Baumgartner WA, et al. Do management strategies for coronary artery disease influence 6-year cognitive outcomes? Ann Thorac Surg 2009;88:445-54.
  • 24. Van Dijk D, Spoor M, Hijman R, Nathoe HM, Borst C, Jansen EW, et al. Cognitive and cardiac outcomes 5 years after off-pump vs on-pump coronary artery bypass graft surgery. JAMA 2007;297:701-8.
  • 25. Van Dijk D, Nierich AP, Jansen EW, Nathoe HM, Suyker WJ, Diephuis JC, et al. Early outcome after off-pump versus on-pump coronary bypass surgery. Circulation 2001;104:1761-6.
  • 26. Plomondon ME, Cleveland JC Jr, Ludwig ST, Grunwald GK, Kiefe CI, Grover FL, et al. Off-pump coronary artery bypass is associated with improved risk-adjusted outcomes. Ann Thorac Surg 2001;72:114-9.
Toplam 26 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Orijinal Araştırmalar
Yazarlar

Fatih Aygün Bu kişi benim

Mehmet Özülkü Bu kişi benim

Yayımlanma Tarihi 1 Nisan 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 21 Sayı: 1

Kaynak Göster

Vancouver Aygün F, Özülkü M. The Effect of Pump on Early Postoperative Mortality and Cerebrovascular Accident in Coronary Bypass Surgery Patients. Koşuyolu Heart Journal. 2018;21(1):9-15.