Monosit/ Yüksek Dansiteli Lipoprotein Kolesterol Oranı Stabil Anjina Pektorisi Olan Hastalarda Safen Ven Greft Açıklığını Öngördürebilir mi?

Yıl 2017, Cilt: 20 Sayı: 1, 7 - 12, 03.04.2017

Yakup Alsancak Sina Ali Serkan Sivri , Hasan Biçer Hatice Duygu Çiftçi Sivri Ayşe Saatçi Yaşar Mehmet Bilge

Öz

Giriş: Dolaşımdaki monosit sayısı yeni aterosklerotik plak gelişimi için
öngördürücü bir faktördür. Ayrıca, yüksek dansiteli lipoprotein kolesterol
(HDL) ile ateroskleroz arasında güçlü bir ters ilişki vardır. Monosit
sayısı/HDL oranının (MHR) yeni bir inflamatuvar belirteç olduğu gösterilmiştir.
Biz MHR ile safen ven greft hastalığı (SVGD) arasındaki ilişkiyi araştırmayı
amaçladık.

Hastalar ve
Yöntem: Toplam 369 hasta 3 gruba bölündü (SVGD olan grup= 150, SVGD
olmayan grup= 89, normal koroner arter grubu= 130). Bazal karakteristikler ve
laboratuvar parametreleri kayıt edildi ve gruplar arasında karşılaştırıldı.

Bulgular: Bazal karakteristiklere göre SVGD olan ve olmayan gruplarda, SVG yaşı ve
sol ventrikül ejeksiyon fraksiyonu haricinde istatistiksel farklılık yoktu.
C-reaktif protein, açlık kan şekeri ve ortalama platelet hacmi SVGD olan grupta
SVGD olmayan gruba göre daha yüksekti (sırasıyla p değerleri= 0.008, 0.048 ve
0.042). MHR değeri SVGD olan, SVGD olmayan (p= 0.169) ve normal koroner arter
grupları (p= 0.364) arasında istatistiksel farklılık göstermedi. CRP, SVGD için
bağımsız öngördürücü faktör olarak bulundu.

Sonuç: MHR ve koroner ateroskleroz
arasında ilişki yoktu. MHR, SVGD için bir öngördürücü faktör değildi.

Anahtar Kelimeler

Monosit sayısı, yüksek dansiteli lipoprotein kolesterol, ateroskleroz, safen ven greft hastalığı

Does Monocyte/High-Density Lipoprotein Cholesterol Ratio Predict Saphenous Vein Graft Patency in Patients with Stable Angina Pectoris?

Öz

Introduction:
Circulating monocyte count is a predictive factor of new
atherosclerotic plaque development. In addition, there is a strong inverse
relationship between high-density lipoprotein (HDL) cholesterol and
atherosclerosis. It has been shown that the monocyte/HDL cholesterol ratio
(MHR) is a novel inflammatory marker. We aimed to investigate the relationship
between MHR and saphenous vein graft disease (SVGD).

Patients
and Methods: A total of 3 69 patients were divided into 3 groups
(positive SVGD group= 150, negative SVGD group= 89, normal coronary artery
group= 130). Baseline characteristics and laboratory parameters were recorded
and compared among the groups.

Results: There were no significant differences between the positive and negative
SVGD groups, except for age of SVG and left ventricular ejection fraction,
according to baseline characteristics. C-reactive protein (CRP) levels, fasting
blood glucose levels and mean platelet volume were higher in the positive SVGD
group than in the negative SVGD group (p= 0.008, 0.048 and 0.042,
respectively). MHR was not significantly different between the positive and
negative SVGD groups (p= 0.169) and normal coronary artery group (p= 0.364).
CRP was found to be an independent predictor factor of SVGD.

Conclusion: There was no association
between MHR and coronary atherosclerosis. MHR was not a predictive factor of
SVGD.

Anahtar Kelimeler

Monocyte count, high-density lipoprotein cholesterol, atherosclerosis, saphenous vein graft disease

Kaynakça

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