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Koroner Yavaş Akımda P Dalga Dispersiyon ve QTc Dispersiyonu

Yıl 2017, Cilt: 20 Sayı: 1, 19 - 23, 03.04.2017

Öz

Giriş: Bu çalışmada  koroner yavaş akım
(KYA) tespit edilen hastalar ile normal koroner anatomi (NKA)  tespit edilen hastalar arasında P dalga
dispersiyonu ve QTc dispersiyonu karşılaştırıldı ve KYA ile P dalga
dispersiyonu ve  QTc dispersiyonu
arasındaki ilişkinin belirlenmesi 
amaçlandı.



Hastalar ve
Yöntem:
Çalışmaya 40 NKA ve 42 KYA olmak üzere toplam 82 hasta
alındı. Koroner kan akımı TIMI kare sayısına göre hesaplandı.
Elektrokardiyografi çekimleri her derivasyon için en az 3 QRS kompleksi
içerecek şekilde, 50 mm/saniye hızında, 20 mV amplitüdünde ve standart 12
derivasyonda çekildi. En uzun p dalgası Pmax ve en kısa p dalgası Pmin olarak
kabul edildi. En uzun P dalgası ile en kısa p dalgası arasındaki farkı P
dispersiyonu kabul edildi. QTc dispersiyonu ölçümleri için öncelikle kalp
hızına göre Bazzet formülü (QT/√R-R) ile düzeltilmiş QT aralığı hesaplandı. En
uzun QTc aralığı (QTcmax) ile en kısa QTc (QTcmin) aralığı arasındaki fark
hesaplanarak ölçüldü. Bütün ölçümler manuel olarak yapıldı.



Bulgular: Bu çalışma  KYA grubunda  P dispersiyonu (sırası ile  53.2 ± 5.35 ve 46.07 ± 4.12,  p< 0.0001),  Pmax (sırası ile 106.2 ± 10.11 ve 97.7 ±
8.17, p< 0.0001), maksimum QTc (sırası ile 438.96 ± 16.77 ve 426.13 ± 10.01,
p< 0.0001) ve QTc dispersiyonu (sırası ile 68.99 ± 4.34 ve 61.64 ± 4.15,
p< 0.0001) sürelerinin NKA grubuna 
göre istatistiksel olarak anlamlı derecede uzun olduğunu göstermektedir.



Sonuç: Bu çalışma koroner yavaş akım da P dalga
dispersiyonu ve QTc dispersiyonu sürelerinin arttığını göstermektedir.

Kaynakça

  • 1. Sezgin AT, Sığırcı M, Barutçu I. Vascular endothelial function in patients with slow coronary flow. Coron Artery Dis 2003;14:155-61.
  • 2. Day CP, McComb JM, Campbell RW. QT dispersion: an indication of arythmia risk in patients with long QT intervals. Br Heart J 1990;63:342-4.
  • 3. Pye MP, Cobbe SM. Mechanisms of venricular arhythmias in cardiac failure and hypertrophy. Cardiovasc Res 1992; 26:740-50.
  • 4. Higham PD, Furniss SS, Campbell RW. QT dispersion and components of the QT interval in ischemia and infarction. Br Heart J 1995;73:32-6.
  • 5. Puljevic D, Smalcelj A, Durokavic Z, Goldner V. Effects of postmyocardial nfarction scar size, cardiac function and severity of coronary artery disease on QT interval dispersion as a risk factor for complex ventricular arrhythmia. Pacing Clin Electropphysiol 1998; 21:1508-16.
  • 6. Kaya Y, Gür AK, Gönüllü E, Güvenç TS, Karakurt A, Güler A, et al. Determination of the relationship between the coronary slow flow phenomenon, and the P-wave Dispersion and QT Dispersion. Kafkas J Med Sci 2012; 2:49-53.
  • 7. Gialafos JE, Dilaveris PE, Gialafos EJ, Andrikopoulos GK, Richter DJ, Triposkiadis F, et al. P dispersion:a valuable electrocardiographic marker for the prediction of paroxysmal lone atrial fibrillation. Ann Noninvasive Electrocardiol 1999;4:39-45.
  • 8. Yılmaz R, Demirbağ R. P-wave dispersion in patients with stable coronary artery disease and its relationship with severity of the disease. J Electrocardiol 2005;38:279-84.
  • 9. Kawano S, Hiraoka M, Sawanobori T. Electrocardiographic features of p waves from patients with transient atrial fibrillation. Jpn Heart J 1988:29;57-67.
  • 10. Dilaveris PE, Gialafos EJ, Sideris S, Theopistou AM, Andrikopoulos GK, Kyriakidis M, et al. Simple electrocardiographic markers for the prediction of paroxysmal idiopathic atrial fibrillation. Am Heart J 1998;135:733-8.
  • 11. Gibson CM, Cannon CP, Daley WL, Dodge JT Jr, Alexander B Jr, Marble SJ, et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation 1996;93:879-88.
  • 12. Mangieri E, Macchiarelli G, Ciavolella M, Barilla F, AvellaA, Martinotti A. Slow coronary flow: clinical and histopathological features in patients with otherwise normal epicardial coronary arteries. Cathet Cardiovasc Diagn 1996;37:375-81.
  • 13. Burckhart BA, Mukerji V, Alpert MA. Coronary artery slow flow associated with angina pectoris and hypertension-a case report. Angiology 1998; 49: 483-7.
  • 14. Saya S, Hennebry TA, Lozano P, Lazzara R, Schechter E. Coronary slow flow phenomenon and risk for sudden cardiac death due to ventricular arrhythmias: a case report and review of literature. Clin Cardiol 2008;31:352-5.
  • 15. Pekdemir H, Cin VG, Çiçek D, Çamsarı A, Akkuş N, Döven O, et al. Slow coronary flow may be a sign of diffuse atherosclerosis. Contribution of FFR and IVUS. Acta Cardiol 2004;59:127-33.
  • 16. Aytemir K, Özer N, Atalar E, Sade E, Aksöyek S, Övünç K, et al. P wave dispersion on 12-lead electrocardiography in patients with paroxysmal atrial fibrillation. Pacing Clin Electrophysiol 2000;23:1109-12.
  • 17. Özer N, Aytemir K, Atalar E, Sade E, Aksöyek S, Övünç K, et al. P wave dispersion in hypertensive patients with paroxysmal atrial fibrillation. Pacing Clin Electrophysiol 2000;23:1859-62.
  • 18. Gökçe M, Görenek B. P Wave Dispersion. Turkish Journal of Arrhythmia, Pacing and Electrophysiology 2003;3:136-43.
  • 19. Papageorgiou P, Monahan K, Boyle NG, Seifert MJ, Beswick P, Zebede J, et al. Sitedependent intra-atrial conduction delay. Relationship to initiation of atrial fibrillation. Circulation 1996;94:384-9.
  • 20. Centurion OA, Isomoto S, Fukatani M, Shimuzu A, Konoe A, Tanigawa, et al. Relationship between atrial conduction defects and fractionated atrial endocardial electrograms in patients with sick sinus syndrome. Pacing Clin Electrophysiol 1993;16:2022-33.
  • 21. Dilaveris PE, Gialafos EJ, Andrikopoulos GK, Richter DJ, Papanikolau V, Poralis K, et al. Clinical and electrocardiographic predictors of recurrent atrial fibrillation. Pacing Clin Electrophysiol 2000;23:352-8.
  • 22. Senen K, Turhan H, Erbay AR, Başar N, Yaşar AS, Şahin O, et al. P-wave duration and P-wave dispersion in patients with dilated cardiomyopathy. Eur J Heart Fail 2004;6:567-9.
  • 23. Yalta K, Yılmaz A, Turgut OO, Yılmaz MB, Bektaşoğlu G, Karadaş F, et al. The effect of coronary collateral circulation on p-wave dispersion in patients with coronary artery disease. CU Med Fac J 2006;28:89-94.
  • 24. Özcan ÖU, Sepehri B, Gürlek A, Erol Ç. Effects of ectasia on electrocardiographic parameters among patients with isolated coronary artery ectasia. MN Cardiol 2015;22:26-9.
  • 25. Nihan F, Çağlar T, Çağlar İM, Aktürk F, Demir B, Yüksel Y, et al. The Association between QT dispersion-QT dispersion ratio and the severity-extent of coronary artery disease in patients with stable coronary artery disease. Istanbul Med J 2014;15:95-100.
  • 26. Meyberg RJ, Kessler KM, Castellanos A. Sudden cardiac death: structure, function and time dependent of risk. Circulation 1992;85(Suppl 1):I: I2-10.
  • 27. Malik M, Batchvarov VN. Measurement. Interpretation and clinical potential of QT dispersion. J Am Call Cardiol 2000;36:1749-66.
  • 28. Giedrimiene D, Giri S, Giedrimas A, Kiernan F, Kluger J. Effects of ischemia on repolarization in patients with single and multivessel coronary disease. Pacing Clin Electrophysiol 2003;26:390-3.
  • 29. Lyras TG, Papapanagiotou VA, Foukarakis MG, Panou FK, Skampas ND, Lakoumentas JA, et al. Evaluation of serial QT dispersion in patients with first non-Q-wave myocardial infarction: Relation to the severity of underlying coronary artery disease. Clin Cardiol 2003;26:189-95.
  • 30. Bayram H, Baştuğ S, Ertem AG, Ayhan H, Sarı C, Kasapkara HA. Comparison of the effects on QT dispersion of off-pump and on-pump coronary artery bypass technique. Sakarya Med J 2015;5:187-92.
  • 31. Nisanoğlu V, Özgür B, Sarı S, Aldemir M, Aksoy Y, Battaloğlu B, et al. Effect of coronary collateral circulation on preoperative and postoperative QT dispersion in patients undergoing coronary artery bypass grafting. J Turgut Ozal Med Cent 2007;14:7-11.

P-Wave and QT Dispersions on Electrocardiography in Coronary Artery Slow Flow Phenomenon

Yıl 2017, Cilt: 20 Sayı: 1, 19 - 23, 03.04.2017

Öz

Introduction:
 The purpose of this study was to analyse
P-wave and QT dispersions on electrocardiography in patients with CSFP and
compare the findings with those of patients with NCA.



Patients
and Methods:
This study included a total of 82 patients (40 patients
with NCA and 42 patients with CSFP). Coronary blood flow was calculated
according to the thrombolysis in myocardial infarction (TIMI) frame count.
Electrocardiograms were obtained at a rate of 50 mm/s and amplitude of 20 mV,
including at least 3 QRS complexes for each derivation, and were taken with 12
standard deviations. The longest P-wave duration was defined as Pmax, and the
shortest P-wave duration was defined as Pmin. The difference between Pmax and
Pmin was defined as P-wave dispersion. QTc, which is the QT interval corrected
for heart rate, was measured according to Bazett’s formula. The difference
between the longest QTc and shortest QTc was considered as QTc dispersion. All
measurements were performed manually.



Results: This study
demonstrated that P-wave dispersion (53.2 ± 5.35 and 46.07 ± 4.12, p <
0.0001, respectively), Pmax (106.2 ± 10.11 and 97.7 ± 8.17, p< 0.0001,
respectively), maximum QTc (438.96 ± 16.77 and 426.13 ± 10.01, p< 0.0001,
respectively) and QTc dispersion (68.99 ± 4.34 and 61.64 ± 4.15, p< 0.0001,
respectively) were significantly prolonged in the CSFP group than the NCA
group.



Conclusion: This study demonstrated that P-wave and QTc
dispersions were prolonged in the CSFP group.

Kaynakça

  • 1. Sezgin AT, Sığırcı M, Barutçu I. Vascular endothelial function in patients with slow coronary flow. Coron Artery Dis 2003;14:155-61.
  • 2. Day CP, McComb JM, Campbell RW. QT dispersion: an indication of arythmia risk in patients with long QT intervals. Br Heart J 1990;63:342-4.
  • 3. Pye MP, Cobbe SM. Mechanisms of venricular arhythmias in cardiac failure and hypertrophy. Cardiovasc Res 1992; 26:740-50.
  • 4. Higham PD, Furniss SS, Campbell RW. QT dispersion and components of the QT interval in ischemia and infarction. Br Heart J 1995;73:32-6.
  • 5. Puljevic D, Smalcelj A, Durokavic Z, Goldner V. Effects of postmyocardial nfarction scar size, cardiac function and severity of coronary artery disease on QT interval dispersion as a risk factor for complex ventricular arrhythmia. Pacing Clin Electropphysiol 1998; 21:1508-16.
  • 6. Kaya Y, Gür AK, Gönüllü E, Güvenç TS, Karakurt A, Güler A, et al. Determination of the relationship between the coronary slow flow phenomenon, and the P-wave Dispersion and QT Dispersion. Kafkas J Med Sci 2012; 2:49-53.
  • 7. Gialafos JE, Dilaveris PE, Gialafos EJ, Andrikopoulos GK, Richter DJ, Triposkiadis F, et al. P dispersion:a valuable electrocardiographic marker for the prediction of paroxysmal lone atrial fibrillation. Ann Noninvasive Electrocardiol 1999;4:39-45.
  • 8. Yılmaz R, Demirbağ R. P-wave dispersion in patients with stable coronary artery disease and its relationship with severity of the disease. J Electrocardiol 2005;38:279-84.
  • 9. Kawano S, Hiraoka M, Sawanobori T. Electrocardiographic features of p waves from patients with transient atrial fibrillation. Jpn Heart J 1988:29;57-67.
  • 10. Dilaveris PE, Gialafos EJ, Sideris S, Theopistou AM, Andrikopoulos GK, Kyriakidis M, et al. Simple electrocardiographic markers for the prediction of paroxysmal idiopathic atrial fibrillation. Am Heart J 1998;135:733-8.
  • 11. Gibson CM, Cannon CP, Daley WL, Dodge JT Jr, Alexander B Jr, Marble SJ, et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation 1996;93:879-88.
  • 12. Mangieri E, Macchiarelli G, Ciavolella M, Barilla F, AvellaA, Martinotti A. Slow coronary flow: clinical and histopathological features in patients with otherwise normal epicardial coronary arteries. Cathet Cardiovasc Diagn 1996;37:375-81.
  • 13. Burckhart BA, Mukerji V, Alpert MA. Coronary artery slow flow associated with angina pectoris and hypertension-a case report. Angiology 1998; 49: 483-7.
  • 14. Saya S, Hennebry TA, Lozano P, Lazzara R, Schechter E. Coronary slow flow phenomenon and risk for sudden cardiac death due to ventricular arrhythmias: a case report and review of literature. Clin Cardiol 2008;31:352-5.
  • 15. Pekdemir H, Cin VG, Çiçek D, Çamsarı A, Akkuş N, Döven O, et al. Slow coronary flow may be a sign of diffuse atherosclerosis. Contribution of FFR and IVUS. Acta Cardiol 2004;59:127-33.
  • 16. Aytemir K, Özer N, Atalar E, Sade E, Aksöyek S, Övünç K, et al. P wave dispersion on 12-lead electrocardiography in patients with paroxysmal atrial fibrillation. Pacing Clin Electrophysiol 2000;23:1109-12.
  • 17. Özer N, Aytemir K, Atalar E, Sade E, Aksöyek S, Övünç K, et al. P wave dispersion in hypertensive patients with paroxysmal atrial fibrillation. Pacing Clin Electrophysiol 2000;23:1859-62.
  • 18. Gökçe M, Görenek B. P Wave Dispersion. Turkish Journal of Arrhythmia, Pacing and Electrophysiology 2003;3:136-43.
  • 19. Papageorgiou P, Monahan K, Boyle NG, Seifert MJ, Beswick P, Zebede J, et al. Sitedependent intra-atrial conduction delay. Relationship to initiation of atrial fibrillation. Circulation 1996;94:384-9.
  • 20. Centurion OA, Isomoto S, Fukatani M, Shimuzu A, Konoe A, Tanigawa, et al. Relationship between atrial conduction defects and fractionated atrial endocardial electrograms in patients with sick sinus syndrome. Pacing Clin Electrophysiol 1993;16:2022-33.
  • 21. Dilaveris PE, Gialafos EJ, Andrikopoulos GK, Richter DJ, Papanikolau V, Poralis K, et al. Clinical and electrocardiographic predictors of recurrent atrial fibrillation. Pacing Clin Electrophysiol 2000;23:352-8.
  • 22. Senen K, Turhan H, Erbay AR, Başar N, Yaşar AS, Şahin O, et al. P-wave duration and P-wave dispersion in patients with dilated cardiomyopathy. Eur J Heart Fail 2004;6:567-9.
  • 23. Yalta K, Yılmaz A, Turgut OO, Yılmaz MB, Bektaşoğlu G, Karadaş F, et al. The effect of coronary collateral circulation on p-wave dispersion in patients with coronary artery disease. CU Med Fac J 2006;28:89-94.
  • 24. Özcan ÖU, Sepehri B, Gürlek A, Erol Ç. Effects of ectasia on electrocardiographic parameters among patients with isolated coronary artery ectasia. MN Cardiol 2015;22:26-9.
  • 25. Nihan F, Çağlar T, Çağlar İM, Aktürk F, Demir B, Yüksel Y, et al. The Association between QT dispersion-QT dispersion ratio and the severity-extent of coronary artery disease in patients with stable coronary artery disease. Istanbul Med J 2014;15:95-100.
  • 26. Meyberg RJ, Kessler KM, Castellanos A. Sudden cardiac death: structure, function and time dependent of risk. Circulation 1992;85(Suppl 1):I: I2-10.
  • 27. Malik M, Batchvarov VN. Measurement. Interpretation and clinical potential of QT dispersion. J Am Call Cardiol 2000;36:1749-66.
  • 28. Giedrimiene D, Giri S, Giedrimas A, Kiernan F, Kluger J. Effects of ischemia on repolarization in patients with single and multivessel coronary disease. Pacing Clin Electrophysiol 2003;26:390-3.
  • 29. Lyras TG, Papapanagiotou VA, Foukarakis MG, Panou FK, Skampas ND, Lakoumentas JA, et al. Evaluation of serial QT dispersion in patients with first non-Q-wave myocardial infarction: Relation to the severity of underlying coronary artery disease. Clin Cardiol 2003;26:189-95.
  • 30. Bayram H, Baştuğ S, Ertem AG, Ayhan H, Sarı C, Kasapkara HA. Comparison of the effects on QT dispersion of off-pump and on-pump coronary artery bypass technique. Sakarya Med J 2015;5:187-92.
  • 31. Nisanoğlu V, Özgür B, Sarı S, Aldemir M, Aksoy Y, Battaloğlu B, et al. Effect of coronary collateral circulation on preoperative and postoperative QT dispersion in patients undergoing coronary artery bypass grafting. J Turgut Ozal Med Cent 2007;14:7-11.
Toplam 31 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Orijinal Araştırmalar
Yazarlar

Mücahid Yılmaz Bu kişi benim

Hasan Korkmaz

Ökkeş Uku Bu kişi benim

Ertuğrul Kurtoğlu Bu kişi benim

Mehmet Nail Bilen Bu kişi benim

Mehmet Akbulut Bu kişi benim

Yayımlanma Tarihi 3 Nisan 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 20 Sayı: 1

Kaynak Göster

Vancouver Yılmaz M, Korkmaz H, Uku Ö, Kurtoğlu E, Bilen MN, Akbulut M. P-Wave and QT Dispersions on Electrocardiography in Coronary Artery Slow Flow Phenomenon. Koşuyolu Heart Journal. 2017;20(1):19-23.