İdiyopatik Perikardiyal Efüzyon ile İnflamatuvar Belirteçler Arasındaki İlişki

Yıl 2017, Cilt: 20 Sayı: 1, 53 - 58, 03.04.2017

Cemil Zencir , Mahmut Akpek Mithat Selvi Sevil Önay Hilal Bektaş Mustafa Yılmaz Mustafa Çetin Kayıhan Kahraman Çağdaş Akgüllü Hüseyin Elbi Hasan Güngör

Öz

Giriş: İnflamasyonun kardiyovasküler hastalıklardaki rolü hakkındaki kanıtların
gittikçe artmasıyla, çalışmalar inflamatuvar markerların hastalık aktivitesi ve
risk değerlendirmesindeki rolüne odaklanmıştır. Bu çalışmanın amacı
inflamatuvar belirteçlerin idiyopatik perikardiyal efüzyonla ile ilişkisini ve
hastalık aktivitesi ile olan korelasyonu olup olmadığının incelenmesidir.

Hastalar ve
Yöntem: Çalışma popülasyonu perikardiyal efüzyonu olan 107 hasta
ile yaş ve cinsiyet olarak benzer 35 sağlıklı gönüllülerden oluşmaktadır. Tüm
hastalar perikardiyal efüzyonun etyolojisine yönelik kapsamlı bir klinik
değerlendirmeye tabi tutulmuştur.

Bulgular: Plevral efüzyonu grubunda, yüksek sensitif C-reaktif protein (Hs-CRP),
nötrofil/lenfosit oranı (NLR) ve platelet/lenfosit oranı (PLR) (herbiri için
p< 0.001), sağlıklı gönüllülerin grubuna göre anlamlı olarak daha yüksekti.
Perikardiyal efüzyonu olan hastalar efüzyon miktarına göre 3 gruba bölündü.
Hs-CRP, NLR ve PLR perikardiyal efüzyon miktarıyla korele bir şekilde
artmaktadır. Çoklu analizde, NLR (OR 1.363, 95% CI 1.026-1.809; p= 0.033)  ve Hs-CRP (OR 1.090, %95 CI 1.030-1.152; p=
0.003), perikardiyal efüzyonu olan hastalarda ciddi perikardiyal efüzyonun
bağımsız bir prediktörleridir.

Sonuç: Hs-CRP, NLR ve PLR perikardiyal efüzyonu olan
hastalarda, hastalık aktivitesi, tedavi monitörizasyonunda ve risk
sınıflamasında kullanılabilir.

Anahtar Kelimeler

Yüksek sensitif C-reaktif protein, nötrofil/lenfosit oranı, perikardiyal efüzyon, platelet/ lenfosit oranı

The Relation of Inflammatory Markers to Idiopathic Pericardial Effusion

Öz

Introduction:
With
the growing evidence about the role of inflammation on cardiovascular
disorders, studies have been focused on inflammatory markers for risk
evaluation and disease activity monitoring. The aim of this study was to
investigate whether inflammation has a role in idiopathic pericardial effusion
(PE) and to reveal its correlation with the disease activity.

Patients
and Methods: The study population consisted of 107 patients with PE
and 35 age-matched and sex-matched healthy volunteers. Each patient underwent a
comprehensive clinical evaluation to identify the probable underlying systemic
diseases or other potential causes for PE.

Results: High-sensitivity
C-reactive protein levels (hs-CRP), neutrophil/lymphocyte ratio (NLR) and
platelet/lymphocyte ratio (PLR) (p< 0.001 for each) were significantly
higher in the PE group than in healthy volunteers. The patients with PE were
divided into three subgroups according to the amount of PE. hs-CRP, NLR and PLR
significantly correlated with the amount of PE. In the multivariate logistic
regression model NLR (OR 1.363, 95% CI 1.026-1.809; p= 0.033) and hs-CRP (OR
1.090, 95% CI 1.030-1.152; p= 0.003) remained as independent predictors of
severe PE in patients who have PE.

Conclusion: hs-CRP, NLR and PLR may be used for disease
activity monitoring, treatment response evaluation and risk stratification of
patients with PE.

Anahtar Kelimeler

High-sensitivity C-reactive protein, neutrophil/lymphocyte ratio, pericardial effusion, platelet/lymphocyte ratio

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