ST Segment Elevasyonlu Miyokart İnfarktüsünde Nötrofil/Lenfosit Oranının Kardiyojenik Şokla İlişkisi

Yıl 2016, Cilt: 19 Sayı: 2, 72 - 75, 01.08.2016

Elnur Alizade , Sinan Cerşit Mustafa Bulut Anıl Avcı Mehmet Mustafa Tabakcı Ahmet Güler Uğur Aslantaş Mehmet Yunus Emiroğlu Selçuk Pala

Öz

Giriş: Nötrofil-lenfosit oranı (NLO) akut koroner sendromların
fizyopatolojisi ile ilişkilidir. ST segment elevasyonlu miyokart infarktüsünde
(STEMİ) gözlenen inflamatuvar süreç NLO’da artışa sebep olabilir. Çalışmamızda,
STEMİ ile hastaneye başvuran hastalarda kardiyojenik şok (KŞ) gelişen ve
gelişmeyen gruplar arasında NLO’da fark olup olmadığı araştırıldı.

Hastalar
ve Yöntem: Çalışmaya akut STEMİ ile başvuran
toplam 203 hasta alındı. Yüz hasta KŞ grubunu oluşturdu. Yüz üç hastada ise
komplikasyonsuz STEMİ mevcuttu. Tüm hastalardan rutin kan örnekleri alındı. NLO
analizi yapıldı.

Bulgular: NLO gruplar arasında anlamlı olarak farklı bulundu (9.9
± 7.9 vs. 6.2 ± 4.3, sırasıyla, p< 0.001). 
“Multiple logistic regression” analizi, KŞ’yle komplike STEMİ’nin şok
izlenmeyen STEMİ hasta grubuna göre daha yüksek NLO değerlerine sahip olduğunu
gösterdi (β= 1.07, %95 CI 1.01-1.15, p= 0.03).

Sonuç: Çalışmamızda hastaneye başvuruda ölçülen NLO’nun  KŞ gelişen STEMİ hastalarında anlamlı olarak
daha yüksek olduğu bulundu. Artmış NLO oranı KŞ gelişecek hastaları predikte
etmede kullanılabilir.

Anahtar Kelimeler

Nötrofil/lenfosit oranı, karsinojenik şok, ST segment elevasyonlu miyokart infarktüsü, inflamasyon, ateroskleroz

Relationship Between Admission Neutrophil to Lymphocyte Ratio and ST-Elevation Myocardial İnfarction Complicated by Cardiogenic Shock

Öz

Introduction: Neutrophil
to lymphocyte ratio (NLR) is related to the pathogenesis of acute coronary
syndromes. The inflammatory process in ST-elevation myocardial infarction
(STEMI) may cause an increase in NLR. In this study, we aimed to investigate
whether admission NLR is associated with STEMI complicated by cardiogenic
shock.

Patients and Methods: The
study population comprised patients who had presented with acute STEMI. All
patients referred underwent routine blood tests, including common blood cell
counts, and NLR analysis.

Results: STEMI
showed characteristics of cardiogenic shock in 100 patients and was
uncomplicated in 103 patients. NLR was significantly different between the two
groups (9.9 ± 7.9 vs. 6.2 ± 4.3, respectively, p< 0.001). Multiple logistic
regression analyses showed that NLR was significantly associated with STEMI
complicated by cardiogenic shock (β= 1.07, 95% CI 1.01-1.15, p= 0.03).

Conclusion: Our results demonstrated that
admission NLR was higher in patients with STEMI complicated by cardiogenic
shock. To prove this relationship between NLR and cardiogenic shock, further
investigations are needed.

Anahtar Kelimeler

Neutrophil to lymphocyte ratio, cardiogenic shock, myocardial infarction, inflammation, atherosclerosis

Kaynakça

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