Kardiyak Sendrom X’li Hastalarda Epikardiyal Yağ Dokusu Kalınlığının ve Serum Omentin Seviyelerinin Değerlendirilmesi

Yıl 2019, Cilt: 22 Sayı: 1, 13 - 19, 11.04.2019

İsmail Ungan Ersan Oflar Alparslan Şahin Esra Dönmez İşler Mustafa Hakan Şahin Vusal Khankishiyev Atilla Koyuncu Alev Kural

Öz

Giriş: Bu çalışmanın amacı kardiyak sendrom X’li hastalarda epikardiyal yağ dokusu ile serum omentin
seviyeleri arasındanki ilişkiyi değerlendirmektir.
Hastalar ve Yöntem: Kliniğimizde tanısı konan 51 kardiyak sendrom X hastası, hasta grubuna ve 46 sağlıklı olgu ise kontrol grubuna dahil edilmiştir. Demografik veriler, rutin labarotuvar testleri hsCRP seviyeleri çalışıldı. Epikardiyal yağ dokusu kalınlığı transtorasik ekokardiyografi ile serum omentin seviyeleri ise
ELISA yontemi ile ölçüldü.
Bulgular: Epikardiyal yağ dokusu kalınlığı hasta grubunda anlamlı olarak daha kalındı (p< 0.001). Kontrol grubu ile karşılaştırıldığında, serum omentin seviyeleri hasta grubunda anlamlı olarak daha düşüktü (p<
0.001). Kardiyak sendrom X’li hastalarda medyan yaş anlamlı olarak daha yüksekti (p< 0.001). Lökosit sayımı ve hsCRP seviyleri iki grup arasından anlamlı farklılık göstermedi (sırasıyla; p= 0.46, p= 0.49 )
Sonuç: Güncel literatüre benzer şekilde, yapmış olduğumuz çalışmamızda, kardiyak sendrom X’li hastalarda epikardiyal yağ dokusu kalınlığının artmış ve serum omentin seviyelerinin düşük olduğunu gösterdik. Bu
bulgular ışığında artmış epikardiyal yağ dokusu, serum omentin seviyelerindeki düşüşe neden olarak koroner
sendrom X hastalığının patolojisinde rol oynayabilir.

Anahtar Kelimeler

Epikardiyal yağ dokusu, omentin, kardiyak sendrom X

Evaluation of the Epicardial Fat Tissue Thickness and Serum Omentin Levels in Patients with Cardiac Syndrome X

Öz

Introduction: The aim of this study was to evaluate the correlation between the epicardial fat tissue thickness
(EFTT) and serum omentin levels in patients with cardiac syndrome X (CSX).
Patients and Methods: A total of 51 patients with CSX admitted to our clinic were included in the patient
group, and 46 healthy subjects were included in the control group. Demographics, routine laboratory tests,
and high sensitive C-reactive protein (hsCRP) levels of all patients were recorded. The EFTT was measured
with transthoracic echocardiography (TTE). Serum omentin levels were measured with the enzyme-linked
immunosorbent assay.
Results: The EFTT was significantly higher in the CSX group (p< 0.001). Serum omentin levels were
significantly lower in patients with CSX in comparison with the control group (p< 0.001). The median age
was significantly higher in the CSX group (p< 0.001). The white blood count and hsCRP levels showed no
significant difference between the CSX and the control group (p= 0.46 and p= 0.49, respectively).
Conclusion: In our study, we found increased epicardial fat tissue (EFT) thickness and decreased serum
omentin levels in patients with CSX, a finding similar with the literature. Thus, increased EFT thickness may
play a role in the pathophysiology of CSX by causing a decrease in the serum omentin level.

Anahtar Kelimeler

Epicardial fat tissue, omentin, cardiac syndrome X

Kaynakça

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