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Beden Kitle İndeksi ile İzole Koroner Baypas Cerrahisi Sonrası Beklenen Göğüs Tüpü Drenajı Arasındaki Negatif Korelasyon

Yıl 2019, Cilt: 22 Sayı: 2, 74 - 78, 15.08.2019

Öz











Giriş: Obezitenin insanlık için iyi bilinen bir tehdit
unsuru olduğu kanıtlanmış bir gerçektir. Ancak yıllar içinde yapılan birtakım
araştırmalarda obezitenin belirli durumlarda koruyucu rolü olduğu gibi çelişik
durumlar gözlemlenmiştir. Bu çalışmada artmış beden kitle indeksi (BKİ)
değerleri ile koroner arter baypas greftleme (KABG) cerrahisi sonrası göğüs
tüpü drenajı arasındaki ilişkiyi ortaya koymayı amaçladık.




Hastalar ve Yöntem: Aralık 2015-Aralık 2016 tarihleri
arasında, izole KABG operasyonu geçirmiş 421 hastanın verileri retrospektif
olarak tarandı. BKİ değerleri, Amerikan Kalp Derneği ve Dünya Sağlık Örgütü
tarafından belirlenen alt sınıflara gruplandırıldı. Bu alt gruplar; zayıf (<
20 kg/m2), normal (20-25 kg/m2), fazla kilolu (25-30 kg/m2), obez (30-35 kg/m2)
ve morbid obez (> 35 kg/m2) olarak kabul edildi. Postoperatif göğüs tüpü drenaj
değeri KABG sonrası ilk 24 saatte ölçülen değer olarak kaydedildi.




Bulgular: Çalışmaya katılan ortalama hasta yaşı 61.6 ± 1.06
idi. Hasta popülasyonunun çoğunluğunu 251 (%59.6) hasta ile erkekler
oluşturmaktaydı. Hastalar önce kabaca obez (> 30 kg/m2) (n= 136) ve non-obez
(< 30 kg/m2) (n= 193) olmak üzere iki gruba ayrıldı. Obez olmayan grupta
postoperatif ortalama göğüs tüpü drenaj miktarı 630 ± 360 mL iken, obez hasta
grubunda 463 ± 303 mL bulundu. BKİ ile KABG sonrası göğüs tüpü drenajı
arasındaki ilişkinin analizi için bağımsız t-test kullanıldı. Test sonucunda
ortaya çıkan ilişki istatistiksel olarak anlamlı idi. Bunun üzerine ileri
analiz amaçlı olarak KABG sonrası göğüs tüpü drenajının beş farklı BKİ alt
grubu ile ilişkisini değerlendirmeye karar verdik. Bunun için varyans analizi
(ANOVA) yapıldı ve sonuçların istatistiksel olarak anlamlı olduğu görüldü.




Sonuç: BKİ ile KABG sonrası göğüs tüpü drenajı arasında
negatif bir korelasyon bulunmaktadır. BKİ’nin ileride planlanabilecek kanama
öngörü skorlarında kullanılabileceğini düşünmekteyiz.



Kaynakça

  • 1. Apovian C, Aronne L. The 2013 American Heart Association/American College of Cardiology/The Obesity Society Guideline for the Management of Overweight and Obesity in Adults. Circulation 2015;132:1586-91.
  • 2. Erem C. Prevalence of overweight and obesity in Turkey. IJC Metabolic&Endocrine 2015;8:38-41.
  • 3. Costa V, Ferolla S, Reis T, Rabello R, Rocha E, Couto C, et al. Impact of body mass index on the outcome in patients undergoing coronary artery bypass grafting and or valve replacement surgery. Revista Brasileira de Cirurgia Cardiovascular, 2015.
  • 4. Roselli E, Pettersson G, Blackstone E, Brizzio M, Houghtaling P, Hauck R, et al. Adverse events during reoperative cardiac surgery: Frequency, characterization, and rescue. The Journal of Thoracic and Cardiovascular Surgery 2008;135:316-23.e6.
  • 5. Guru V, Fremes S. Impact of off-pump coronary artery bypass surgery on postoperative bleeding: Current best available evidence. Journal of Cardiac Surgery 2006;21:42-3.
  • 6. Nolan H, Davenport D, Ramaiah C. BMI Is an independent preoperative predictor of intraoperative transfusion and postoperative chest-tube out-put. International Journal of Angiology 2013;22:031-06.
  • 7. Reeves B, Ascione R, Chamberlain M, Angelini G. Effect of body mass index on early outcomes in patients undergoing coronary artery bypass surgery. ACC Current Journal Review 2003;12:63.
  • 8. Gruberg L, Weissman N, Waksman R, Fuchs S, Deible R, Pinnow E, et al. The impact of obesity on the short-term andlong-term outcomes after percutaneous coronary intervention: the obesity paradox? Journal of the American College of Cardiology 2002;39:578-84.
  • 9. Le-Bert G, Santana O, Pineda A, Zamora C, Lamas G, Lamelas J. The obesity paradox in elderly obese patients undergoing coronary artery bypass surgery. Interactive CardioVascular and Thoracic Surgery 2011;13:124-7.
  • 10. Alam M, Siddiqui S, Lee V, Elayda M, Nambi V, Yang E, et al. Isolated coronary artery bypass grafting in obese individuals. Circulation Journal 2011;75:1378-85.
  • 11. Wang M, Chen M, Ao H, Chen S, Wang Z. The effects of different BMI on blood loss and transfusions in chinese patients undergoing coronary artery bypass grafting. Annals of Thoracic and Cardiovascular Surgery 2017;23:83-90.
  • 12. Mertens I, Gaal L. Obesity, haemostasis and the fibrinolytic system. Obesity Reviews 2002;3:85-101.
  • 13. Jia Z, Tian G, Ren Y, Sun Z, Lu W, Hou X. Pharmacokinetic model of unfractionated heparin during and after cardiopulmonary bypass in cardiac surgery. Journal of Translational Medicine 2015;1-11.
  • 14. Aykut A, Sabuncu Ü, Demir ZA, Balcı E, Soran Türkcan B, Ünal U, et al. Heparin dose calculated according to lean body weight during on-pump heart surgery. Turkish Journal of Thoracic and Cardiovascular Surgery 2018;26.
  • 15. Vivacqua A, Koch C, Yousuf A, Nowicki E, Houghtaling P, Blackstone E, et al. Morbidity of bleeding after cardiac surgery: is it blood transfusion, reoperation for bleeding, or both? The Annals of Thoracic Surgery 2011;91:1780-90.
  • 16. Brascia D, Onorati F, Reichart D, Perrotti A, Ruggieri V, Santarpino G, et al. Prediction of severe bleeding after coronary surgery: the WILL-BLEED Risk Score. Thrombosis and Haemostasis 2017;117:445-56.
  • 17. Mariscalco G, Gherli R, Ahmed A, Zanobini M, Maselli D, Dalén M, et al. Validation of the european multicenter study on coronary artery bypass grafting (E-CABG) bleeding severity definition. The Annals of Thoracic Surgery 2016;101:1782-8.

Negative Correlation Between Body Mass Index and Chest Tube Out-put After Coronary Artery Bypass Graft Surgery

Yıl 2019, Cilt: 22 Sayı: 2, 74 - 78, 15.08.2019

Öz











Introduction: The
obvious threat of obesity to human life is well-known, but some contradictory
outcomes have been encountered during previous medical research. Interestingly,
obesity was recognized as a protective factor for some specific obesity-related
situations. We aimed to correlate increased body mass index (BMI) and chest
tube out-put after coronary artery bypass grafting (CABG).



 



Patients and Methods:
We retrospectively collected data of 421 patients who underwent isolated CABG
surgery between dates of December 2015 and December 2016. Obtained BMI values
were grouped into: underweight (< 20 kg/m2 ), normal weight (20-25 kg/m2 ),
overweight (25-30 kg/m2 ), obese (30-35 kg/m2 ), and severely obese (> 35 kg/m2
) subclasses. The postoperative chest tube output volume corresponded drainage
at first 24 hours after the CABG surgery.



 



Results: The mean age
was 61.6 (± 1.06) years. Female to male ratio was found 40, 9/59, 6 (n=
170/251). The patient population was divided into 2 groups as BMI below and
above 30 kg/m2 to approximately evaluate the relation between BMI and chest
tube out-put. Overall, 193 patients were in the non-obese group, and 136
patients were in the obese group. The mean drainage amounts of non-obese and
obese groups were 630 ± 360 and 463 ± 303 mL, respectively. We ran independent
t-test to evaluate the relationship between BMI and chest tube out-put. It was
statistically significant. The relationship between drainage and five different
BMI subgroups was evaluated. Analysis of variance (ANOVA) showed statistically
significant chest tube output difference between the normal and obese groups as
well as the severely obese group.



 



Conclusion: BMI is
negatively correlated with bleeding after CABG surgery and should be considered
in future bleeding prediction systems.



Kaynakça

  • 1. Apovian C, Aronne L. The 2013 American Heart Association/American College of Cardiology/The Obesity Society Guideline for the Management of Overweight and Obesity in Adults. Circulation 2015;132:1586-91.
  • 2. Erem C. Prevalence of overweight and obesity in Turkey. IJC Metabolic&Endocrine 2015;8:38-41.
  • 3. Costa V, Ferolla S, Reis T, Rabello R, Rocha E, Couto C, et al. Impact of body mass index on the outcome in patients undergoing coronary artery bypass grafting and or valve replacement surgery. Revista Brasileira de Cirurgia Cardiovascular, 2015.
  • 4. Roselli E, Pettersson G, Blackstone E, Brizzio M, Houghtaling P, Hauck R, et al. Adverse events during reoperative cardiac surgery: Frequency, characterization, and rescue. The Journal of Thoracic and Cardiovascular Surgery 2008;135:316-23.e6.
  • 5. Guru V, Fremes S. Impact of off-pump coronary artery bypass surgery on postoperative bleeding: Current best available evidence. Journal of Cardiac Surgery 2006;21:42-3.
  • 6. Nolan H, Davenport D, Ramaiah C. BMI Is an independent preoperative predictor of intraoperative transfusion and postoperative chest-tube out-put. International Journal of Angiology 2013;22:031-06.
  • 7. Reeves B, Ascione R, Chamberlain M, Angelini G. Effect of body mass index on early outcomes in patients undergoing coronary artery bypass surgery. ACC Current Journal Review 2003;12:63.
  • 8. Gruberg L, Weissman N, Waksman R, Fuchs S, Deible R, Pinnow E, et al. The impact of obesity on the short-term andlong-term outcomes after percutaneous coronary intervention: the obesity paradox? Journal of the American College of Cardiology 2002;39:578-84.
  • 9. Le-Bert G, Santana O, Pineda A, Zamora C, Lamas G, Lamelas J. The obesity paradox in elderly obese patients undergoing coronary artery bypass surgery. Interactive CardioVascular and Thoracic Surgery 2011;13:124-7.
  • 10. Alam M, Siddiqui S, Lee V, Elayda M, Nambi V, Yang E, et al. Isolated coronary artery bypass grafting in obese individuals. Circulation Journal 2011;75:1378-85.
  • 11. Wang M, Chen M, Ao H, Chen S, Wang Z. The effects of different BMI on blood loss and transfusions in chinese patients undergoing coronary artery bypass grafting. Annals of Thoracic and Cardiovascular Surgery 2017;23:83-90.
  • 12. Mertens I, Gaal L. Obesity, haemostasis and the fibrinolytic system. Obesity Reviews 2002;3:85-101.
  • 13. Jia Z, Tian G, Ren Y, Sun Z, Lu W, Hou X. Pharmacokinetic model of unfractionated heparin during and after cardiopulmonary bypass in cardiac surgery. Journal of Translational Medicine 2015;1-11.
  • 14. Aykut A, Sabuncu Ü, Demir ZA, Balcı E, Soran Türkcan B, Ünal U, et al. Heparin dose calculated according to lean body weight during on-pump heart surgery. Turkish Journal of Thoracic and Cardiovascular Surgery 2018;26.
  • 15. Vivacqua A, Koch C, Yousuf A, Nowicki E, Houghtaling P, Blackstone E, et al. Morbidity of bleeding after cardiac surgery: is it blood transfusion, reoperation for bleeding, or both? The Annals of Thoracic Surgery 2011;91:1780-90.
  • 16. Brascia D, Onorati F, Reichart D, Perrotti A, Ruggieri V, Santarpino G, et al. Prediction of severe bleeding after coronary surgery: the WILL-BLEED Risk Score. Thrombosis and Haemostasis 2017;117:445-56.
  • 17. Mariscalco G, Gherli R, Ahmed A, Zanobini M, Maselli D, Dalén M, et al. Validation of the european multicenter study on coronary artery bypass grafting (E-CABG) bleeding severity definition. The Annals of Thoracic Surgery 2016;101:1782-8.
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Orijinal Araştırmalar
Yazarlar

Mehmet Aksüt Bu kişi benim 0000-0002-0280-7890

Ekin Can Çelik 0000-0002-9404-7306

Deniz Günay Bu kişi benim 0000-0003-1656-6984

Tanıl Özer Bu kişi benim 0000-0002-2701-2058

Mustafa Mert Özgür Bu kişi benim 0000-0001-8204-9008

Mehmet Kaan Kırali Bu kişi benim 0000-0003-0044-4691

Yayımlanma Tarihi 15 Ağustos 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 22 Sayı: 2

Kaynak Göster

Vancouver Aksüt M, Çelik EC, Günay D, Özer T, Özgür MM, Kırali MK. Negative Correlation Between Body Mass Index and Chest Tube Out-put After Coronary Artery Bypass Graft Surgery. Koşuyolu Heart Journal. 2019;22(2):74-8.