ST Yükselmeli Miyokart İnfarktüslü Hastalarda C-Reaktif Protein/Albumin Oranı ile Yeni Başlangıçlı Atriyal Fibrilasyon Arasındaki İlişkinin Değerlendirilmesi

Yıl 2019, Cilt: 22 Sayı: 2, 100 - 106, 15.08.2019

Mahmut Yesin Metin Çağdaş Yavuz Karabağ İbrahim Rencüzoğulları Macit Kalçık Cengiz Burak Tufan Çınar Süleyman Karakoyun Ozan Mustafa Gürsoy İbrahim Tanboğa

Öz

Giriş: Daha önceden
yapılan çalışmalar, inflamatuvar belirteçlerin koroner arter hastalığı olan
hastalarda yeni başlayan atriyal fibrilasyon (AF)’un gelişimi ile ilişkili
olduğunu göstermiştir. Bununla birlikte, ST yükselmeli miyokart infarktüslü
(STEMİ) hastalarda AF gelişimi için serum C-reaktif protein (CRP)’in serum
albumin oranı (CAR)’na göre prediktif değeri henüz araştırılmamıştır. Bu
nedenle, bu çalışmada, primer perkütan koroner girişim (pPKG) yapılan STEMİ
hastalarında AF’ı öngörmedeki değerini değerlendirmeyi amaçladık.

 

Hastalar ve Yöntem:
Bu çalışma, pPKG uygulanan 1153 STEMİ hastasına ilişkin verilerin geriye
yönelik analiz edilmesi ile yapıldı. CRP düzeyleri immünoturbidimetrik yönteme
göre ölçüldü ve serum albumin düzeyleri bromkresol yeşili yöntemiyle analiz
edildi. CAR, CRP değerlerinin serum albumin oranı olarak tanımlandı.

 

Bulgular: Hastanede
kalış sırasında AF insidansı %5.2 (n= 62 hasta) idi. AF olan hastalar, AF
olmayanlara kıyasla yüksek CAR değerlerine sahipti. Çok değişkenli lojistik regresyon
analizleri, yüksek CAR değerinin AF’ın bağımsız bir belirleyicisi olduğunu
ortaya koydu (OR: 3.280, %95 CI: 1.564-6.878; p= 0.002). Ayrıca, ROC curve
eğrilerinin karşılaştırıldığında, CAR’ın öngörücü performansının sırasıyla CRP
ve albuminden daha yüksek olduğunu göstermiştir.

 

Sonuç: Bu çalışmada
pPKG ile tedavi edilen STEMİ hastalarında yüksek CAR değerlerinin AF gelişimi
ile bağımsız olarak ilişkili olduğunu gözlemledik.

Anahtar Kelimeler

C-reaktif protein/albumin oranı, yeni başlayan atriyal fibrilasyon, ST yükselmeli miyokart infarktüsü

Assessment of the Relationship Between C-Reactive Protein to Albumin Ratio and New-Onset Atrial Fibrillation in Patients with ST Elevation Myocardial Infarction

Öz

Introduction:
Previous studies reported that inflammatory markers are associated with the
development of new-onset atrial fibrillation (NOAF) in patients with coronary
artery disease. However, the predictive value of serum C-reactive protein (CRP)
to serum albumin ratio (CAR) for the development of NOAF in patients with ST
elevation myocardial infarction (STEMI) has not been investigated yet. Hence,
the aim of the present study was to evaluate the potential utility of the CAR
in predicting NOAF in patients with STEMI who underwent primary percutaneous
coronary intervention (pPCI).

 

Patients and Methods:
The present study was a retrospective analysis of the data related to 1153
patients with STEMI who underwent pPCI. CRP levels were measured according to
the immunoturbidimetric method, and serum albumin levels were analyzed by the
bromocresol green method. The CAR was defined as the serum CRP level divided by
the serum albumin level.

 

Results: The
incidence of NOAF during in-hospital stay was 5.2% (n= 62 patients). Patients
with NOAF had higher CAR values than those without NOAF. Multivariate logistic
regression analyses revealed that elevated CAR value was an independent
predictor of NOAF (odds ratio 3.280, 95% confidence interval 1.564-6.878; p=
0.002). Furthermore, comparison of receiver operating characteristic curves
yielded that the predictive performance of CAR was higher than CRP and albumin
alone, respectively.

 

Conclusion: In the
present study, we observed that elevated CAR values were independently
associated with NOAF development in patients with STEMI treated with pPCI.

Anahtar Kelimeler

C-reactive protein to albumin ratio, new-onset atrial fibrillation, ST elevation myocardial infarction

Kaynakça

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