The Relationship Between Atherosclerotic Risk Factors and Female Gender

Yıl 2023, Cilt: 26 Sayı: 2, 48 - 54, 12.07.2023

Asibe Özkan Esra Karagöz

Öz

Introduction: Identification and control of cardiovascular risk factors form the basis of strategies for protecting cardiovascular health. However, according to the results of many studies, women are less aware of their own risk factors and participate less in screening programs than men. This study was conducted to determine the risk of experiencing atherosclerotic events and risk-related factors in women aged 40-79 years.

Patients and Methods: This retrospective, cross-sectional analysis was conducted by the primary physician of the laboratory values used in atherosclerotic cardiovascular disease (ASCVD) risk assessment, who applied to the consultant outpatient clinics (pulmonary diseases, infectious diseases, nephrology, internal medicine outpatient clinics) in a training and research hospital between September and November 2021. The data of 131 female patients between the ages of 40-79 were analyzed.

Results: The average age of the 131 women included in the study was 51.6 years. It was observed that women predominantly had three or four risk factors. The five most common risk factors identified were as follows: a total cholesterol level above 170 mg/dL (86.3%), menopause (65.6%), HDL cholesterol below 50 mg/dL (64.1%), systolic blood pressure above 130 mmHg (56.4%), and smoking (32.1%). In the study, when investigating the relationship between the ASVCD risk calculator, atherosclerosis risk factors, and the menopausal period, statistically significant associations were observed between age, systolic blood pressure, total cholesterol, HDL, LDL, 10-year risk ratio, optimal risk ratio, and lifetime risk ratio.

Conclusion: The study determined that the average lifelong expected ASCVD risk among the women participating in the study, in terms of cardiovascular diseases, was 39.87 ± 8.81%. This finding highlights the significance of cardiovascular diseases and underscores the importance of conducting comprehensive risk assessments at the individual level to prevent them.

Anahtar Kelimeler

Atherosclerosis, cardiovascular diseases; menopause, risk assessment, women’s health

Kaynakça

• 1. Tanrıverdi B, Savaş Tetik Ş. Aterosklerozun patofizyolojisi ve risk faktörleri. Marmara Pharmaceutical J 2017;21:1-9. [Crossref]
• 2. Mora S, Wenger NK, Cook NR, Liu J, Howard BV, Limacher BC, et al. Evaluation of the pooled cohort risk equations for cardiovascular risk prediction in a multiethnic cohort from the women’s health initiative. JAMA Intern Med 2018;178(9):1231-40. [Crossref]
• 3. Rosenfeld AG. State of the heart: Building science to ımprove women’s cardiovascular health. Am J Crit Care 2006;15(6):556-66. [Crossref] 54 Koşuyolu Heart J 2023;26(2):48-54 ● Atherosclerotic Risk Factors and Female Gender
• 4. Mosca L, Mochari-Greenberger H, Dolor RJ, Newby LK, Robb KJ. Twelve-year follow-up of american women’s awareness of cardiovascular disease risk and barriers to heart health. Circ Cardiovasc Qual Outcomes 2010;3(2):120-7. [Crossref]
• 5. Öz Alkan H, Enç N. Kadınlarda kardiyovasküler hastalıkların önlenmesinde hemşirenin rolü. Turk Soc Turkish J Cardiovasc Nurs 2013;4(5):14- 29. [Crossref]
• 6. Papas A. Raising women’s awareness of cardiovascular risks. Elsevier Masson Consulte 2017;66(233):22-3. [Crossref]
• 7. TÜİK. Ölüm nedeni istatistikleri. Available from: http://www.tuik.gov.tr/ PreHaberBultenleri.do?id=30626 (Accessed date: 14.07.2022).
• 8. Onat A. TEKHARF 2017 Tıp dünyasının kronik hastalıklarına öncülük. Available from: https://file.tkd.org.tr/PDFs/TEKHARF-2017.pdf (Accessed date: 25.06.2022).
• 9. Zengin H. Aterosklerozis patogenezi. J Exp Clin Med 2012;29:101-6. [Crossref]
• 10. Çengel A. TKD Kadın ve kalp sağlığı proje ekibi makaleleri-Kadınlarda kardiyovasküler risk faktörleri. Arch Turk Soc Cardiol 2010;38(1):17-24.
• 11. Kim KY, Hong S, Han K, Park CY. Assessing the validity of the criteria for the extreme risk category of atherosclerotic cardiovascular Disease: A nationwide population-based study. J Lipid Atheroscler 2022;11(1):73-83. [Crossref]
• 12. Langlois MR, Nordestgaat BG, Langsted A, Chapman MJ, Aakre KM, Baum H, et al. Quantifying atherogenic lipoproteins for lipid-lowering strategies: Consensus-based recommendations from EAS and EFLM. Clin Chem Lab Med 2020;58(4):496-517. [Crossref]
• 13. Özcan H, Oskay Ü. Menopoz döneminde semptom yönetiminde kanıta dayalı uygulamalar. Göztepe Tıp Derg 2013;28(4):157-63.
• 14. Kızıltan G. Kadın ve kalp damar sağlığı. Turkiye Klinikleri 2015;1(1):47- 53.
• 15. Alquaiz AM, Kazi A, Alodhayani AA, Almeneessier A, Alhabeeb AA, Sıddık AR, et al. Age and gender differences in the prevalence of chronic diseases and atherosclerotic cardiovascular disease risk scores in adults in Riyadh city, Saudi Arabia. Saudi Med J 2021;42(5):526-36. [Crossref]
• 16. Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study. Lancet 2004;364(9438):937-52. [Crossref]
• 17. Eray A, Set T, Ateş E. Yetişkin bireylerde kardiyovasküler hastalık riskinin değerlendirilmesi. Türk Aile Hek Derg 2018;22(1):12-9. [Crossref]
• 18. Li Y, Zhu G, Ding V, Jiang B, Ball RL, Ahuja N, et al. Assessing the relationship between American Heart Association atherosclerotic cardiovascular disease risk score and coronary artery imaging findings. J Comput Assist Tomogr 2018;42(6):898-905. [Crossref]
• 19. Öztürk Turhan N, Simavlı S, İnegöl Gümüş İ. Postmenopozal hormon tedavisi kardiyovasküler hastalık riskini azaltıyor mu? Yeni Tıp Derg 2010;27:76-9.
• 20. Özcan H, Kızılkaya Beji N. Menopoz döneminde cinsellik. Türk Fertilite Derg 2014;58:209-11.
• 21. Kurrelmeyer K. Cardiovascular disease in women. Methodist Debakey Cardiovasc J 2017;13(4):183-4. [Crossref]
• 22. Newson L. Menopause and cardiovascular disease. Post Reprod Health 2018;24(1):44-9. [Crossref]
• 23. Zilberman JM. Menopause: Hypertension and vascular disease. Hipertens Riesgo Vasc 2018;35(2):77-83. [Crossref]
• 24. Zhu D, Chung HF, Dobson AJ, Pandeya N, Giles GG, Bruinsma F, et al. Age at natural menopause and risk of incident cardiovascular disease: A pooled analysis of individual patient data. Lancet Pub Health 2019;4(11):553-64. [Crossref]
• 25. El-Khoudary SR. Age at menopause onset and risk of cardiovascular disease around the world. Maturitas 2020;141:33-8. [Crossref]
• 26. Tekeşin Aİ, Hayıroğlu Mİ, Çinier G, Soluk Özdemir Y, İnan D, Yüksel G, et al. Yüksek kardiyovasküler riski olan hastalarda mobil teknoloji ve akıllı cihazlar kullanılarak yaşam tarzı müdahalesi: Pragmatik, randomize bir klinik çalışma. Turk Kardiyol Dern Ars. 2020; 48(2): 149-157