KEMİK İLİĞİ METASTAZI OLAN SOLİD MALİGNİTELİ HASTALARDA KLİNİK VE LABORATUVAR PARAMETRELERİNİN ÖNEMİ-TEK MERKEZ DENEYİMİ

Öz

Amaç: Solid tümörlerde kemik iliği biyopsisi, kemik iliği tutulumunun tanısında etkili ve kesin bir tanı yöntemidir. Son yıllarda, kemik iliği incelemesi tümörlerin metastatik tutulumunu belgelemede giderek daha kullanışlı hale gelmiştir. Yöntem: Merkezimizde solid malignitesi olan ve hematolojik parametrelerinde anormallikleri olan hastaların periferik kan morfolojisi değerlendirildi. Hasta özellikleri; periferik kan sayımları, periferik kan morfolojisi, önceki tedavilerini dahil edecek şekilde kaydedildi. Bu çalışmanın amacı; solid kanserli hastalarda açıklanamayan hematolojik anormallikler için kemik iliği biyopsisi ve aspirasyonunu incelemek, bu tür hastaların patolojik bulgularını, klinik ve hematolojik laboratuvar özelliklerini ve sonuçlarını kurumumuzda araştırmaktı. Ayrıca bu hastaların yönetimi ve sağkalımı ile ilgili detaylar bildirildi. Bulgular: Kemik iliği biyopsi tutulumu olmayan grupta daha düşük RDW-Cv değeri, kemik iliği biyopsi tutulumu olan gruba göre istatistiksel olarak anlamlı bulundu (p=0,005; p<0.01). Kemik iliği biyopsisi tutulumu olmayan grubun fibrozis değerinin kemik iliği biyopsisi tutulumu olan gruba göre daha düşük olması istatistiksel olarak anlamlı bulundu (p=0.016; p<0.05). Kemik iliği biyopsi tutulumu olmayan grubun LDH değerinin kemik iliği biyopsi tutulumu olan gruba göre daha düşük olması istatistiksel olarak anlamlı bulundu (p=0,002; p<0.01). Kemik iliği biyopsi tutulumu ile periferik yayma bulguları (p=0.001; p<0.01), PET-BT'de kemik iliği tutulumu (p=0.001; p<0.01), anemi (p=0.028; p<0.05) ve kemik metastazı (p=0.001; p<0.01) arasında istatistiksel olarak anlamlı ilişki bulundu. Sonuç: Bu çalışmanın sonucunda klinik pratikte açıklanamayan hematolojik anormallikler, özellikle açıklanamayan anemi ve yüksek RDW ve LDH parametreleri saptandığında kemik iliği metastazı şüphesi düşünülmeli ve kesin tanı için kemik iliği biyopsisi önerilmektedir.

Anahtar Kelimeler

• Solid Tümör
• Kemik İliği Biyopsi
• Metastaz

THE IMPORTANCE OF CLINICAL AND LABORATORY PARAMETERS OF BONE MARROW METASTASIS IN PATIENTS WITH SOLID MALIGNANCY-SINGLE CENTER EXPERIENCE

Öz

Objective: Bone marrow biopsy is an efficient and reliable diagnostic procedure for the identification of bone marrow involvement. In recent years, bone marrow examination has become more helpful in documenting the metastatic involvement of malignancies. Method: Patients with solid tumors and anomalies in hematological parameters had their peripheral blood morphology examined at our facility. Each instance included information on the patient's peripheral blood counts, peripheral blood morphology, and prior therapies. The purpose of this study was to analyze bone marrow biopsy and aspiration for unexplained hematological abnormalities in solid cancer patients and to look into the pathological findings, clinical and hematological laboratory features, and outcomes of such patients in our facility. Additionally, we provided information on the treatment and prognosis of these patients. Results: When compared to the group that had bone marrow biopsy involvement, the lower RDW-Cv value in the former group was shown to be statistically significant (p=0.005; p<0.01). It was determined that the difference between the fibrosis values of the groups with and without bone marrow biopsy involvement was statistically significant (p=0.016; p<0.05). It was determined to be statistically significant (p=0.002; p<0.01) that the LDH value of the group without bone marrow biopsy involvement was lower than that of the group with BM biopsy involvement. Anemia (p=0.028; p<0.05), bone metastases (p=0.001; p<0.01), bone marrow biopsy involvement in PET-CT (p=0.001; p<0.01), and peripheral smear results (p=0.001; p<0.01) all showed a statistically significant correlation. Conclusion: In conclusion, bone marrow metastasis should be considered when inexplicable hematological abnormalities, particularly unexplained anemia, and elevated RDW and LDH parameters are found in clinical practice. A bone marrow biopsy is advised for a conclusive diagnosis.

Anahtar Kelimeler

• Solid Malignancy
• Bone Marrow Biopsy
• Metastasis

Kaynakça

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