KOAH HASTALARINDA VÜCUT AĞIRLIĞI-YÜRÜME MESAFESİNİN SAĞLIKLA İLİŞKİLİ YAŞAM KALİTESİ İLE İLİŞKİSİ: 6 DAKİKALIK YÜRÜME MESAFESİ İLE KARŞILAŞTIRMALI BİR ÇALIŞMA

Öz

Amaç: Bu çalışmanın amacı, geliştirilmiş bir sonuç ölçütü olarak 6 dakika yürüme testi mesafesi-vücut ağırlığı çarpımı (yani 6 dakikalık yürüme işi-6DK-İŞİ) ile sağlıkla ilişkili yaşam kalitesi arasındaki ilişkiyi incelemek ve bu ilişkiyi 6 dakika yürüme testi mesafesi ile karşılaştırmaktı. Yöntem: Bu retrospektif kesitsel çalışmaya orta-ağır KOAH'lı toplam 81 hasta (ortalama yaş: 61.0±4.6 yıl) dahil edildi. Çalışma Ocak 2025 ile Mart 2025 tarihleri arasında gerçekleştirildi. Hastaların klinik özellikleri, akciğer fonksiyon testleri, 6 dakika yürüme testi mesafeleri ve Saint George Solunum Anketi (SGRQ) ile ölçülen sağlıkla ilişkili yaşam kalitesi sonuçları kaydedildi. 6DK-İŞİ, 6 dakika yürüme testi mesafesi ve vücut ağırlığının birbiriyle çarpımı olarak hesaplandı ve kg.metre (kg.m) olarak kaydedildi. SGRQ ile 6 dakika yürüme testi mesafesi ve 6DK-İŞİ arasındaki korelasyon katsayıları ve basit doğrusal regresyonlar değerlendirildi. Bulgular: Hastaların ortalama 6 dakika yürüme testi mesafesi ve 6DK-İŞİ sırasıyla 441.5±83.3 m ve 33176.2±9865.8 kg.m idi. 6DK-İŞİ SGRQ alt alanlarıyla (r=−.582 ile −.641 arasında, p<.001) 6 dakika yürüme testi mesafesine (r =−.381 ile −.455 arasında, p<.001) kıyasla daha güçlü korelasyonlar gösterdi. Ayrıca basit doğrusal regresyon analizine göre, SGRQ toplam puanı ile 6 dakika yürüme testi mesafesi arasındaki belirleme katsayısı (R2) .207 iken 6DK-İŞİ ise .411 idi. Sonuç: Bulgularımız 6 dakika yürüme testinde kat edilen basit mesafe yerine 6DK-İŞİ’nin kullanılmasının, yaşam kalitesi ile ilişkisi nedeniyle orta-ağır KOAH'lı hastalarda daha avantajlı olduğunu göstermektedir. Bu nedenle 6DK-İŞİ orta-ağır KOAH'lı hastalarda fonksiyonel kapasiteyi tahmin etmek için daha etkili bir sonuç parametresi olabilir. Daha geniş, daha çeşitli popülasyonlarla ve uzunlamasına tasarımlarlı gelecek çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

• KOAH
• Yaşam Kalitesi
• Altı Dakika Yürüme Testi
• Vücut Ağırlığı

CORRELATION OF THE BODY WEIGHT-WALKING DISTANCE WITH HEALTH-RELATED QUALITY OF LIFE IN PATIENTS WITH COPD: A COMPARATIVE STUDY WITH THE 6-MINUTE WALK DISTANCE

Öz

Objective: This study aimed to examine the relationship between the 6-minute walk test distance – body weight product (i.e. 6-minute walk work-6MWORK) as an improved outcome measure with health-related quality of life and to compare this relationship with the 6-minute walk test distance. Method: A total of 81 patients (mean age: 61.0±4.6 years) with moderate-to-severe COPD were included in this retrospective cross-sectional study. This study conducted between January 2025 and March 2025. The patients' clinic characteristics, lung function tests, 6-minute walk test distance, and health-related quality of life measured by Saint George Respiratory Questionnaire (SGRQ) outcomes were recorded. The 6MWORK was calculated as product of 6-minute walk test distance and body weight by multiplying each other and recorded as kg.meters (kg.m). Correlation coefficients and simple linear regressions were evaluated between SGRQ with 6-minute walk test distance and 6MWORK. Results: The mean 6-minute walk test distance and 6MWORK of patients were 441.5±83.3 m and 33176.2±9865.8 kg.m, respectively. The 6MWORK showed stronger correlations with SGRQ sub-domains (r=−.582 to −.641, p <.001) compared to the 6-minute walk test distance (r=−.381 to −.455, p<.001). Moreover, according to simple linear regression analysis, the coefficient of determination (R2) between SGRQ total score and the 6-minute walk test distance was .207, whereas it was .411 with 6MWORK. Conclusion: Our findings suggest that the use of 6MWORK instead of simple distance covered in a 6-minute walk test is more advantageous in patients with moderate-to-severe COPD due to its relationship with quality of life. Thus, the 6MWORK may be a more effective outcome for estimating functional capacity in patients with moderate-to-severe COPD. Future studies with larger, more diverse populations and longitudinal designs are needed.

Anahtar Kelimeler

• COPD
• Quality Of Life
• Six-Minute Walk Test
• Body Weight

Kaynakça

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