Neutrophil to lymphocyte ratio on admission: Is a predictor of cardiovascular outcome in patients with acute coronary syndrome as it predicts mortality ?

Yıl 2014, Cilt: 17 Sayı: 3, 153 - 158, 01.03.2013

Murat Eren Ebru Özpelit Fatih Aytemiz Hasan Güngör Sema Güneri

Öz

Introduction: It has been recently shown that inflammation may play a role in acute coronary syndrome (ACS). The risk classification of the patients with ACS is inadequite, it requires improving with new and practical parameters. The aim of this study was to invastigate the utility of admission neutrophil / lymphocyte ratio (NLR) in predicting the likelihood of poor outcomes in patients with ACS. Patients and Methods: 209 consecutive patients (mean age: 63.0+10.7, 152 men) admitted to our department with the diagnosis of ACS were included in this study. Patients were divided into three, low (4.7) according to the NLR. The admitting findings, laboratory values, GRACE and TIMI risk scores was recorded and in-hospital mortality, and the total mortality/hospitalisation due to cardiovasculary complications after discharge evaluated in three NLR groups. Results: Significant positive correlation was found between NLR and CRP (p=0.001, r=0.238) troponin I (p

Anahtar Kelimeler

Acute coronary syndrome, cardiovascular outcome, mortality, neutrophil to lymphocyte ratio

Başvuru sırasındaki nötrofil/lenfosit oranı: Akut koroner sendromlu hastalarda mortalitenin olduğu gibi kardiyovasküler sonuçların da bir öngördürücüsü müdür ?

Öz

Giriş: İnflamasyonun miyokardiyal iskemide önemli bir rol oynadığı gösterilmiştir. Bu hastaların risk sınıflaması açık noktalar içermektedir ve gösterilmiş bu yüksek risk özellikleri yeni ve daha pratik parametreler ile geliştirilmeye ihtiyaç göstermektedir. Bu çalışmada akut koroner sendrom (AKS) tanılı hastalarda başvuru sırasında değerlendirilen nötrofil /lenfosit oranın (NLR) kötü kardiyovasküler sonuçları ve mortaliteyi öngördürücü özelliği değerlendirilmeye çalışılmıştır.Hastalar ve Yöntem: Merkezimizde AKS tanısı (anstabil anjina pektoris / ST-segment yükselmesi olmayan AKS / ST segment yükselmeli AKS ) ile tedavi görmüş 209 hasta çalışmaya dahil edildi. Hastalar NLR'ye göre düşük ( 4,7 ) olmak üzere 3 grup altında değerlendirildi. Hastaların başvuru bulguları, laboratuvar değerleri, GRACE ve TIMI risk skorları kaydedildi ve hastane içi mortalite, 6. ay ve taburculuk sonrası mortalite ve kardiyak nedenli hastane yatış NLR grupları arasında karşılaştırıldı. Bulgular: NLR ile CRP ( p=0,001 r=0,238 ) troponin I (p=

Anahtar Kelimeler

Akut koroner sendrom, kardiyovasküler sonuçlar, mortalite, nötrofil lenfosit oranı

Kaynakça

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