IN-STENT RESTENOSIS

Yıl 2006, Cilt: 10 Sayı: 2, 34 - 47, 01.02.2006

Osman Karakaya Ali Metin Esen

Öz

The introduction of intracoronary stents into clinical practice has dramatically changed treatment of obstructive coronary artery disease. Unfortunately, the procedure's utility is limited by a frequent complication: restenosis At the moment, repeat balloon angioplasty is considered to be the first line treatment option, especially in focal lesions. The recent introduction of drug-eluting stents (DESs) may help prevent ISR. However, DESs have not been universally successful, and they may introduce new complications that require further refinement. This review summarizes the current understanding of the pathogenesis of ISR and provides an objective overview of DESs.

Anahtar Kelimeler

PTCA, stent, restenosis, drug eluting stents

Stent Içi Restenoz

Öz

Koroner girisimlerde stentlerin kullanılması koroner arter hastalıgının tedavisini dramatik olarak degistirmistir. Ancak bu girisim sıklıkla restenoz adı verilen bir süreçle sınırlanmaktadır. Restenozun özellikle fokal restenozların ilk tedavi seçenegi tekrarlayan balon anjiyoplastilerdir. Son yıllarda ilaç kaplı stentlerin (IKS) kullanılmaya baslanmasıyla birlikte stent içi restenoz oranları azalmaya baslamıstır. Bununla beraber IKS kullanımında universal bir basarı tanımlanmamıs üstelik yeni komplikasyonların tanınmaya baslamasıyla tartısılır hale gelmistir. Bu derlemede stent içi restenozun fizyopatolojisini güncel bilgiler ısıgında anlamayı ve IKS lerin bu süreci nasıl etkiledigini gözden geçirecegiz

Anahtar Kelimeler

Osman Karakaya

Kaynakça

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