Synthesis of Temperature-Sensitive Hyaluronic Acid Hydrogels Containing Flaxseed Mucilage

Yıl 2025, Cilt: 11 Sayı: 2, 240 - 252, 31.12.2025

Halide Ceren Hazavitligil Burcu Okutucu

https://doi.org/10.34186/klujes.1686769

Öz

Hydrogels are cross-linked polymeric structures synthesized through the reaction of one or more monomers. Depending on their monomer sources, hydrogels can be natural or synthetic polymeric materials. Hydrogels prepared from natural biopolymers are used in the medical field due to their biocompatibility, biodegradability, low toxicity, high flexibility resembling natural tissue characteristics, and ease of modification. Natural biopolymers can be carbohydrates, proteins, or mucilages derived from animal, plant, or waste sources. Plant-based biopolymers (mucilage) are preferred as hydrogel components because they are non-toxic, low-cost, non-irritating, and act as natural softening agents.

Hyaluronic acid is widely used in cosmetic products, wound healing drugs, tissue regeneration and treatment, as well as various medical (implant) applications
In this study, hyaluronic acid hydrogels were synthesized using flaxseed mucilage, selected as the natural biopolymer component, and the temperature-sensitive monomer poly(N-isopropylacrylamide) (PNIPAM). By incorporating flaxseed mucilage as a natural component, the elasticity of temperature-sensitive hyaluronic acid hydrogels was enhanced, thereby increasing their potential for medical applications.

Anahtar Kelimeler

Temperature- Sensitive Hydrogel , Flaxseed , Mucilage , Hyaluronic acid

Proje Numarası

Ege Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimine (22937)

Keten Tohumu Müsilajı İçeren Sıcaklık Duyarlı Hyaluronik Asit Hidrojellerinin Sentezi

Öz

Hidrojeller, bir veya daha fazla monomerin reaksiyonu ile sentezlenen çapraz bağlı polimerik yapılardır. Hidrojeller monomer kaynaklarına göre doğal ve sentetik polimerik malzemelerdir. Doğal biyopolimerlerden hazırlanan hidrojeller; biyolojik olarak uyumlu olmaları, biyolojik olarak parçalanabilir olmaları, düşük toksisiteye sahip olmaları, karakteristik dokuya benzer şekilde yüksek derecede esnekliğe sahip olmaları ve modifikasyonlarının kolay olmasından dolayı medikal alanda kullanılmaktadırlar. Doğala biyopolimerler hayvansal, bitkisel ya da atıklardan elde edilen karbohidrat, protein ya da müsilajlar olabilir. Hidrojel bileşeni olarak bitki bazlı biyopolimer (müsilaj) toksik olmaması, düşük maliyeti, yumuşatıcı ve tahriş edici olmaması nedeniyle tercih edilir. Hyaluronik asit; kozmetik ürünlerin üretiminde, yara için ilaçların üretiminde, doku rejenerasyonunda ve tedavisinde ve bir çok medikal (implant) kullanım alanı mevcuttur Bu çalışmada doğal biyopolimer bileşeni olarak seçilen Keten tohumu müsilajı ve sıcaklık duyarlı monomer poli (N- izopropilakrilamid) PNIPAM ile Hyaluronik asit hidrojelinin sentezi gerçekleştirildi. Doğal bileşeni keten tohumu müsilajı olan sıcaklık duyarlı hyaluronik asit hidrojellerinin elastikiyetini artırarak medikal kullanım olanakları arttırılmıştır.

Anahtar Kelimeler

Sıcaklık duyarlı hidrojel , Keten tohumu , Müsilaj , Hyaluronik asit

Etik Beyan

Etik izne tabi bir çalışma değildir

Destekleyen Kurum

Ege Üniversitesi

Proje Numarası

Ege Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimine (22937)

Teşekkür

Yüksek Biyokimyager Hüseyin Özay’a ve Ege Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimine (22937) teşekkür ederiz.

Kaynakça

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