ULTRASONIC-PROMOTED SYNTHESIS OF FUNCTIONALIZED TETRAHYDROPYRIDINES USING TRIFLATE

Yıl 2017, Cilt: 3 Sayı: 2, 107 - 122, 30.12.2017

Zuhal Turgut , Emel Pelit

Öz

An easy, and effective multicomponent synthesis of a
highly substituted tetrahydropyridines has been achieved by reaction of
different substituted aromatic aldehydes, β-ketoester (methyl acetoacetate),
and p-methoxyaniline, in the presence of ytterbium(III)
trifluoromethanesulfonate, Yb(OTf)₃, 
as an efficient catalyst under ultrasound irradiation. This method has
supplied a different approach for the synthesis of highly substituted
tetrahydropyridines in moderate to good yields.

Anahtar Kelimeler

Heterocycles, tetrahydropyridine, triflate, ultrasound

ULTRASONIC-PROMOTED SYNTHESIS OF FUNCTIONALIZED TETRAHYDROPYRIDINES USING TRIFLATE

Öz

Yüksek derecede sübstitüe edilmiş
tetrahidropiridinler, iterbiyum(III)triflorometansülfonat Yb(OTf)₃ katalizörlüğünde,
farklı sübstitüe aromatik aldehitler, β-ketoester (metil asetoasetat) ve
p-metoksianilinin kolay ve etkili reaksiyonuyla ultrason ışıması altında elde
edilmiştir. Bu yöntem yüksek derecede sübstitüe edilmiş tetrahidropiridinlerin
iyi verimlerle sentezi için farklı bir yaklaşım sağlamıştır.

Anahtar Kelimeler

Heterosiklikler, tetrahidropiridin, triflat, ultrason

Kaynakça

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