Polibromlu Dibenzo-p-Dioksinler/Furanlar (PBDD/F'lar) ve Hegzabromosiklododekanlar (HBCDD’lar): Kimyasal Oluşum, İzleme, Etki ve Ölçüm

Fatma Şevval Sönmez; Barış Güzel; Oltan Canlı

doi:10.53410/koufbd.1178809

Polibromlu Dibenzo-p-Dioksinler/Furanlar (PBDD/F'lar) ve Hegzabromosiklododekanlar (HBCDD’lar): Kimyasal Oluşum, İzleme, Etki ve Ölçüm

Öz

Kalıcı organik kirleticiler (KOK'lar), biyolojik olarak parçalanmamaları nedeniyle çevrede daha uzun süre kalabilen organik kimyasallardır. Polibromlu dibenzo-p-dioksinler/furanlar (PBDD/F’ler), istemeden üretilen ve Stockholm Sözleşmesi'ne henüz dahil olmamış kirleticilerdir. PBDD/F’ler poliklorlu dibenzo-p-dioksinler/furanlar (PCDD/F'ler) gibi kalıcı halojenize organik kirleticiler olup, lipofilik ve biyoakümülatif özelliklerinden ötürü besin zincirlerinde birikerek insan sağlığı ve çevre üzerinde olumsuz sonuçlar doğurma potansiyeline sahiptirler. PBDD/F'ler esas olarak bromlu alev geciktiricilerin (BFR’lerin) yanması, elektrikli ve elektronik ekipmanların sökülmesi, metal eritme ve atık yakma gibi termal koşullar altında ortaya çıkmaktadır. Hegzabromosiklododekanlar (HBCDD’lar) ise Stockholm KOK'lar Sözleşmesi'nin Ek A kısmında listelenmiş olup; insan maruziyetinin meydana geldiği başta su, toz, hava ve toprak yoluyla taşınarak çevreyi kirletirler. Kontamine olmuş yiyecekler, nefes alma ve içme suyu, insanların HBCDD'lere maruz kalması için üç önemli yoldur. Özellikle balık tüketimi, insanların HBCDD'lere maruz kalmasının ana yollarından biridir. Günümüzde, varlığı, özellikleri, etkileri ve ölçüm yöntemleri de dahil olmak üzere PBDD/F'ların ve HBCDD'lerin kapsamlı bir açıklanması eksiktir; bu nedenle, bu derleme bu bilgileri sağlamak için yapılmıştır.

Anahtar Kelimeler

Kaynakça

[1] Jensen, S., Johnels, A.G., Olsson, M., Otterlin, G., 1969. DDT and PCB in marine animals from Swedish waters. Nature 224, 247‐250.
[2] Arnoldsson, K., 2012. Polybrominated dibenzo-p-dioxins: natural formation mechanisms and biota retention, maternal transfer, and effects. Umeå Universitet, Doctoral Dissertation.
[3] Xiao, X. Hu, J. Chen, D. Bi, X., 2016. Characterization of polybrominated dibenzo-p-dioxins and dibenzo-furans (PBDDs/Fs) in environmental matrices from an intensive electronic waste recycling site, South China. Environmental Pollution 212, 464-471.
[4] Shen, X., Yang, Q., Shen, J., Yang, L., Wang, M., Yang, Y., Liu, G., 2021. Characterizing the emissions of polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs) from electric arc furnaces during steel-making. Ecotoxicology and Environmental Safety 208, 11722.
[5] Lin, Y., Le, S., Feng, C., Qiu, X., Xu, Q., Jin, S., Lu, D., 2021. Exposure and health risk assessment of secondary contaminants closely related to brominated flame retardants (BFRs): Polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs) in human milk in Shanghai. Environmental Pollution 268, 115121.
[6] Canli, O., Güzel, B., Karademir, A., 2022. Determination of PCDD/F and DL-PCB pollution levels, source appointment and risk assessment of surface sediments in dam lakes in Istanbul, Türkiye. Environmental Science and Pollution Research 60(29), 90923-90935.
[7] Ebert, J., Bahadir, M., 2003. Formation of PBDD/F from flame-retarded plastic materials under thermal stress. Environment International 29, 711-716.
[8] Zhou, Y., Liu, J., 2018. Emissions, environmental levels, sources, formation pathways, and analysis of polybrominated dibenzo-p-dioxins and dibenzofurans: A review. Environmental Science and Pollution Research 25(33), 33082-33102.

[9] Hanari, N., Kannan, K., Miyake, Y., Okazawa, T., Kodavanti, P.R.S., Aldous, K.M., Yamashita, N., 2006. Occurrence of polybrominated biphenyls, polybrominated dibenzo-p-dioxins, and polybrominated dibenzofurans as ımpurities in commercial polybrominated diphenyl ether mixtures. Environment Science & Technology 40(14), 4400-4405.
[10] Ren, M., Cai, Y., Chen, D., Zhou, L.,Chen, P., Hu, J., 2011. PBDD/F impurities in some commercial deca-BDE. Environmental Pollution 159 (5), 1375-1380.
[11] Andersson, Ö., Blomkvist, G., 1981. Polybrominated aromatic pollutants found in fish from Sweden. Chemosphere 10, 1051–1060.
[12] Law, R.J., Covaci, A., Harrad, S., Herzke, D., Abdallah, M.A.E., Fernie, K., 2014. Takigami, H., Levels and trends of PBDEs and HBCDs in the global environment: Status at the end of 2012. Environment International 65, 147-158.
[13] Altarawneh, M., Saeed, A., Al-Harahsheh, M., Dlugogorski, B.Z., 2019. Thermal decomposition of brominated flame retardants (BFRs): Products and mechanisms. Progress in Energy and Combustion Science 70, 212–259.
[14] Zhang, M.M., Buekens, A., Li, X.D., 2016a. Brominated flame-retardants and the formation of dioxins and furans in fires and combustion. Journal of Hazardous Materials, 304, 26–39.
[15] Bjurlid, F., Roos, A., Jogsten, I.E. Hagberg, J., 2018. Temporal trends of PBDD/Fs, PCDD/Fs, PBDEs and PCBs in ringed seals from the Baltic Sea (pusa hispida botnica) between 1974 and 2015. Science of the Total Environment 616, 1374–1383.
[16] Jogsten, I.E., Hagberg, J., Lindstrom, G., Bavel, B., 2010. Analysis of POPs in human samples reveal a contribution of brominated dioxin of up to 15% of the total dioxin TEQ. Chemosphere 78 (2), 113–120.
[17] Song, A., Li, H., Liu, M., Hu, J., Sheng, G., Ying, G., 2022. Polybrominated dibenzo-p-dioxins/furans (PBDD/Fs) in soil around municipal solid waste incinerator: A comparison with polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs). Environmental Pollution 293, 118563.
[18] Sellström, U., Kierkegaard, A., Wit, C.D., Jansson, B., 1998. Polybrominated diphenyl ethers and hexabromocyclododecane in sediment and fish from a swedish river. Environmental Toxicology and Chemistry 17, 1065–1075.
[19] De Wit, C.A., Herzke, D., Vorkamp, K., 2010. Brominated flame retardants in the arctic environment–trends and new candidates. Science of the Total Environment 408, 2885–2918.
[20] Zhang, Y., Ruan, Y., Sun, H., Zhao, L., Gan, Z., 2013. Hexabromocyclododecanes in surface sediments and a sediment core from rivers and harbor in the northern chinese city of Tianjin. Chemosphere 90, 1610–1616.
[21] Alaee, M., Arias, P., Sjodin, A., Bergman, A., 2003. An overview of commercially used brominated flame retardants, their applications, their use patterns in different countries/regions and possible modes of release. Environment International 29(6), 683-689.
[22] Zhang, Y.Q., Li, Q.F., Lu, Y.L., Jones, K., Sweetman, A.J., 2016b. Hexabromocyclododecanes (HBCDDs) in surface soils from coastal cities in north China: Correlation between diastereoisomer profiles and ındustrial activities. Chemosphere 148, 504-510.
[23] Cao, X., Lu, Y., Zhang, Y., Khan, K., Wang, C., Baninla, Y., 2018. An overview of Hexabromocyclododecane (HBCDs) in environmental media with focus on their potential risk and management in China. Environmental Pollution 236, 283-295.
[24] Feiteiro, J., Mariana, M., Cairrão, E., 2021. Health toxicity effects of brominated flame retardants: from environmental to human exposure. Environmental Pollution 285, 117475.
[25] Güzel, B., 2022. Temporal Variations and Source Identification of Polycyclic Aromatic Hydrocarbons (PAHs) in Rainwater Collected in a Semi-Urban Area within an Industrial Area in Turkey. Polycyclic Aromatic Compounds 42(8), 4965-4983.
[26] POPRC, 2011. Report of the Persistent Organic Pollutants Review Committee on the Work of its Seventh Meeting: Risk Management Evaluation on Hexabromocyclododecane. UNEP/POPS/POPRC.7/19/Add.
[27] POPRC, 2012. Report of the Persistent Organic Pollutants Review Committee on the Work of its Eighth Meeting: Addendum to the Risk Management Evaluation on Hexabromocyclododecane. UNEP/POPS/POPRC.8/16/Add.3,
[28] Lin, Y., Le, S., Feng, C., Qiu, X., Xu, Q., Jin, S., Lu, D., 2021. Exposure and health risk assessment of secondary contaminants closely related to brominated flame retardants (BFRs): Polybrominated dibenzo-p-dioxins and dibenzofurans (PBDD/Fs) in human milk in Shanghai. Environmental Pollution 268, 115121.
[29] Piskorska-Pliszczynska, J., Maszewski, S., 2014. Brominated dioxins: Little-Known new health hazards - A review. Bulletin of Veterinary Institute in Pulawy 58, 327-335.
[30] Pajurek, M., Pietron, W., Maszewski, S., Mikolajczyk, S., Piskorska-Pliszczynska, J., 2019. Poultry eggs as a source of PCDD/Fs, PCBs, PBDEs and PBDD/Fs. Chemosphere 223, 651-658.
[31] Fernandes, A.R., Falandysz, J., 2021. Polybrominated dibenzo-p-dioxins and furans (PBDD/Fs): contamination in food, humans and dietary exposure. Science of the Total Environment 761, 143191.
[32] Ortuno, N., Conesa, J.A., Molto, J., Font, R., 2014. De novo synthesis of brominated dioxins and furans. Environmental Science & Technology 48(14), 7959–7965.
[33] Goto, A., Tue, N.M., Someya, M., Isobe, T., Takahashi, S., Tanabe, S., Kunisue, T., 2017b. Occurrence of natural mixed halogenated dibenzo-p-dioxins: specific distribution and profiles in mussels from seto ınland Sea, Japan. Environmental Science & Technology 51(20), 11771–11779.
[34] Van den Berg, M., Denison, M.S., Birnbaum, L.S., DeVito, M.J., Fiedler, H., Falandysz, J., Rose, M., Schrenk, D., Safe, D., Tohyama, C., Tritscher, A., Tysklind, M., Peterson, R.E., 2013. Polybrominated dibenzo-p-dioxins, dibenzofurans, and biphenyls: Inclusion in the toxicity equivalency factor concept for dioxin-like compounds. Toxicological Sciences 133(2), 197–208.
[35] Ballschmiter, K., Bacher, R., 2008. Dioxine - Chemie, Analytik, Vorkommen, Umweltverhalten und Toxikologie der halogenierten Dibenzo-p-dioxine und Dibenzofurane, VCH Weinheim, 3-527-28768-X, 1196.
[36] WHO, 1998. Environmental Health Criteria 205: Polybrominated Dibenzo-p-dioxins and Dibenzofurans, World Health Organisation, Geneva, Switzerland.
[37] Heeb, N.V., Schweizer, W.B., Kohler, M., Gerecke, A.C., 2005. Structure elucidation of hexabromocyclododecanes - A class of compounds with a complex stereochemistry. Chemosphere 61(1), 65–73.
[38] Hunziker, R.W., Gonsior, S., MacGregor, J.A., Desjardins, D., Ariano, J., Friederich, U., 2004. Fate and effect of hexabromocyclododecane in the environment. Organohalogen Compounds 66, 2300-2305.
[39] Janák, K., Covaci, A., Voorspoels, S., Becher, G., 2005. Hexabromocyclododecane in marine species from the western scheldt estuary: Diastereoisomer- and enantiomer-specific accumulation Environmental Science & Technology 39, 1987–1994.
[40] Lyche, J.L, Rosseland, C., Berge, G., Polder, A., 2015. Human health risk associated with brominated flame-retardants (BFRs). Environment International 74, 170-180.
[41] Karahan, İ., 2018. Investigation of Biotic Degradation of Hexabromocyclododecane (HBCDD), Middle East Technical University, Master's Thesis, Ankara.
[42] Bakış, P., 2007. Enantiyomerik Saflıkta 1-Fenil-1-Propanolün Transesterleşme Tepkimesiyle Biyoreaktörde Kinetik Rezolüsyonu, Ankara Üniversitesi, Yüksek Lisans Tezi, Fen Bilimleri Enstitüsü, Kimya Mühendisliği Anabilim Dalı, Ankara.
[43] Zegers, B.N., Mets, A., Van Bommel, R., Minkenberg, C., Hamers, T., Kamstra, J.H., Pierce, G.J., Boon, J.P., 2005. Levels of hexabromocyclododecane in harbor porpoises and common dolphins from western european seas, with evidence for stereoisomer-specific biotransformation by cytochrome P450. Environmental Science & Technology 39, 2095–2100.
[44] Abdallah, M., Harrad, S., 2009. Personal exposure to HBCDs and ıts degradation products via ıngestion of ındoor dust. Environment International 35, 870–876.
[45] Johnson-Restrepo, B., Adams, D.H., Kannan, K., 2008. Tetrabromobisphenol A (TBBPA) and hexabromocyclododecanes (HBCDs) in tissues of humans, dolphins, and sharks from the United States. Chemosphere 70, 1935–1944.
[46] Schecter, A., Szabo, D.T., Miller, J., Gent, T.L., Malik-Bass, N., Petersen, M., Birnbaum, L.S., 2012. Hexabromocyclododecane (HBCD) stereoisomers in US food from Dallas, Texas. Environmental Health Perspectives 120(9), 1260-1264.
[47] Davis, J.W., Gonsior, S.J., Marty, G., Ariano, J., 2005. The transformation of hexabromocyclododecane in aerobic and anaerobic soils and aquatic sediments. Water Research 39(6), 1075-1084.
[48] Güzel, B., Canli, O., Celebi, A., 2022. Characterization, Source and Risk Assessments of Sediment Contaminants (PCDD/Fs, DL-PCBs, PAHs, PCBs, OCPs, Metals) in the Urban Water Supply Area. Applied Geochemistry 143, 105394, 1-10.
[49] Rose, M., Fernandes, A., 2010. Are BFRs responsible for brominated dioxins and furans (PBDD/Fs) in food?. Proceedings of the 5th International Symposium on Brominated Flame-Retardants, Kyoto, Japan.
[50] Canli, O., Çetintürk, K., Güzel, B., 2023. A comprehensive assessment, source input determination and distribution of Persistent Organic Pollutants (POPs) along with Heavy Metals (HMs) in reservoir lake sediments from Çanakkale province, Türkiye. Environmental Geochemistry and Health 45 (6), 3985-4006.
[51] Güzel, B., Canli, O., Dede, D., Karademir, A., 2020. Assessment of PCDD/F and dioxin-like PCB levels in environmental and food samples in the vicinity of IZAYDAS waste ıncinerator plant (WIP): from past to present. Environmental Science and Pollution Research 27, 13902-13914.
[52] Covaci, A., Voorspoels, S., Ramos, L., Neels, H., Blust, R., 2007. Recent developments in the analysis of brominated flame-retardants and brominated natural compounds. Journal of Chromatography A 1153(1-2), 145-171.
[53] Kuc, J., Grochowalski, A., 2014. Methods for the determination of hexabromocyclododecane in food. Technical Transactions Chemistry 111, 45–55.
[54] Plassmann, M.M., Schmidt, M., Brack, W., Krauss, M., 2015. Detecting a wide range of environmental contaminants in human blood samples-combining QuEChERS with LC-MS and GC-MS methods. Analytical and Bioanalytical Chemistry 407, 7047–7054.
[55] Yuan, J.P., Sun, Y.M., Liu, J.H., Yao, Y.X., Chen, Y., 2016. Determination of hexabromocyclododecane enantiomers in chicken whole blood by a modified quick, easy, cheap, effective, rugged, and safe method with liquid chromatography and tandem mass spectrometry. Journal of Separation Science 39, 2846–2852.
[56] Li, J., Chen, T., Wang, Y., Shi, Z., Zhou, X., Sun, Z., Wang, D., Wu, Y., 2017. Simple and fast analysis of tetrabromobisphenol A, hexabromocyclododecane ısomers, and polybrominated diphenyl ethers in serum using solid-phase extraction or quechers extraction followed by tandem mass spectrometry coupled to HPLC and GC. Journal of Separation Science 40, 709–716.
[57] Schrenk, D., Bignami, M., Bodin, L., Chipman, J.K., del Mazo, J., Vleminckx, C., 2021. Update of the risk assessment of hexabromocyclododecanes (HBCDDs) in food. EFSA Journal 19(3), e06421.
[58] Zhou, S.N., Reiner, E.J., Marvin, C., Kolic, T., Riddell, N., Helm, P., Brindle, I.D., 2010. Liquid Chromatography–atmospheric pressure photoionization tandem mass spectrometry for analysis of 36 halogenated flame retardants in fish. Journal of Chromatography A 1217(5), 633-641.
[59] Butt, C.M., Miranda, M.L., Stapleton, H.M., 2016. Development of an analytical method to quantify PBDEs, OH-BDEs, HBCDs, 2,4,6-TBP, EH-TBB, and BEH-TEBP in human serum. Analytical and Bioanalytical Chemistry 408, 2449–2459.
[60] Baek, S.Y., Lee, S., Kim, B., 2017. separation of hexabromocyclododecane diastereomers: Application of C18 and phenyl‐hexyl ultra‐performance liquid chromatography columns. Journal of Chromatography A 1488, 140–145.
[61] Zacs, D., Rjabova, J., Pugajeva, I., Nakurte, I., Viksna, A., Bartkevics, V., 2014. Ultra high performance liquid chromatography–time-of-flight high resolution mass spectrometry in the analysis of hexabromocyclododecane diastereomers: Method development and comparative evaluation versus ultra high performance liquid chromatography coupled to orbitrap high resolution mass spectrometry and triple quadrupole tandem mass spectrometry. Journal of Chromatography A 1366, 73–78.
[62] Riddell, N., Van Bavel, B., Ericson-Jogsten, I., McCrindle, R., McAlees, A., Chittim, B., 2017. Coupling supercritical fluid chromatography to positive ıon atmospheric pressure ionization mass spectrometry: Ionization optimization of halogenated environmental contaminants. International Journal of Mass Spectrometry 421, 156–163.
[63] Zacs, D., Rjabova, J., Bartkevics, V., 2013. Occurrence of brominated persistent organic pollutants (PBDD/DFs, PXDD/DFs, and PBDEs) in baltic wild salmon (salmo salar) and correlation with PCDD/DFs and PCBs. Environmental Science & Technology 47(16), 9478-9486.
[64] Fernandes, A., Mortimer, D., Rose, M., Smith, F., Panton, S., 2014. Brominated dioxins and PBDEs: Occurrence trend in UK food. Organohalogen Compouds 76, 764-767.
[65] Diletti, G., Ceci, R., De Benedictis, A., Leva, M., Migliorati, G., Pirito, L., Fernandes, A.R., Polybrominated dibenzo-p-dioxins and furans (PBDD/Fs) in italian food: Occurrence and dietary exposure. Science of the Total Environment 741, 139916, 2020.
[66] Fernandes, A.R., Mortimer, D., Gem, M., Dicks, P., Smith, F., White, S., Rose, M., 2009. Polybrominated diphenylethers (PBDEs) and brominated dioxins (PBDD/Fs) in Irish food of animal origin. Food Addititives & Contaminants – Part B 2, 86–94.
[67] Mortimer, D., Acheampong, R., Fernandes, A., Rose, M., 2013. Consumer exposure to chlorinated and brominated dioxins and biphenyls and polybrominated diphenyl ethers: New UK total diet study. Organohalogen Compouds 75, 1138-1141.
[68] Fernandes, A., D’Silva, K., Driffield, M., White, S., Rose, M., Branch, E.C., Rose, M., 2005. Brominated Flame-Retardants and Brominated Dioxins in 2003 Total Diet samples, In Report to the Food Standards Agency, London, UK. Report FD-04/37.
[69] URL-1, 1995. Toxic Chemicals, https://www.epa.gov/ toxics-release-inventory-tri-program/tri-listed-chemicals.
[70] BfR Expert Opinion, 2007. Impact of the Revised Toxicity Equivalency Factors (TEFs) on The Toxic Equivalents (TEQs) of the World Health Organisation.
[71] Fromme, H., Hilger, B., Albrecht, M., Gries, W., Leng, G., Völkel, W., 2016. Occurrence of chlorinated and brominated dioxins/furans, PCBs, and brominated flame retardants in blood of german adults. International Journal Hygiene and Environmental Health 219(4-5), 380-388.
[72] Barghi, M., Shin, E.S., Kim, J.C., Choi, S.D., Chang, Y.S., 2017. Human exposure to HBCD and TBBPA via indoor dust in Korea: Estimation of external exposure and body burden. Science of the Total Environment 593, 779-786.
[73] Morris, S., Allchin, C.R., Zegers, B.N., Haftka, J.J., Boon, J.P., Belpaire, C., De Boer, J., 2004. Distribution and fate of HBCD and TBBPA brominated flame retardants in north sea estuaries and aquatic food webs. Environmental Science & Technology 38(21), 5497-5504.
[74] Barghi, M., Shin, E.S., Choi, S.D., Behrooz, R.D., Chang, Y.S., 2018. HBCD and TBBPA in human scalp hair: Evidence of internal exposure. Chemosphere 207, 70-77.
[75] Schuhmacher, M., Nadal, M., Domingo, J.L., 2009. Environmental monitoring of PCDD/Fs and metals in the vicinity of a cement plant after using sewage sludge as a secondary fuel. Chemosphere 74(11), 1502-1508.
[76] Schlummer, M., Moser, G.A., McLachlan, M.S., 1998. Digestive tract absorption of PCDD/Fs, PCBs, and HCB in humans: mass balances and mechanistic considerations. Toxicology and Applied Pharmacology 152(1), 128-137.
[77] Safe, S.H., Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annual Review of Pharmacology and Toxicology 26(1), 371-399, 1986.
[78] Ssebugere, P., Sillanpää, M., Matovu, H., Mubiru, E., 2019. Human and environmental exposure to PCDD/Fs and dioxin-like PCBs in Africa: A review. Chemosphere 223, 483-493.
[79] EFSA, 2005. Opinion of the scientific panel on contaminants in the food chain on a request from the commission related to the presence of non dioxin-like polychlorinated biphenyls (PCB) in feed and food. The EFSA Journal 284, 1-13.
[80] Chen, H.L., Su, H., Guo, Y.L., Liao, P.C., Hung, C.F., Lee, C.C., 2006. Biochemistry examinations and health disorder evaluation of taiwanese living near ıncinerators and with low serum PCDD/Fs levels. Science of the Total Environment 366(2-3), 538-548.
[81] Birnbaum, L.S., Staskal, D.F., Diliberto, J.J., 2003. Health effects of polybrominated dibenzo-p-dioxins (PBDDs) and dibenzofurans (PBDFs). Environment International 29(6), 855-860.
[82] Lundstedt, S., 2016. Sources and Levels of PBDD/Fs in the Swedish Environment, 43-55.
[83] Yu, Y.J., Li, Z.R., Zhu, Y., Li, L.Z., Zhang, L.H., Xiang, M.D., Zeng, E.Y., 2022. Significance of biotransformation and excretion on the enantioselective bioaccumulation of hexabromocyclododecane (HBCDD) in laying hens and developing chicken embryos. Journal of Hazardous Materials 422, 126749.
[84] Fernandes, A.R., Mortimer, D., Rose, M., Smith, F., Panton, S., Garcia-Lopez, M., 2016. Bromine content and brominated flame retardants in food and animal feed from the UK. Chemosphere 150, 472-478.
[85] Coelho, S.D., Sousa, A.C.A., Isobe, T., Kim, J.W., Kunisue, T., Nogueira, A.J.A., Tanabe, S., 2016. Brominated, chlorinated and phosphate organic contaminants in house dust from Portugal. Science of the Total Environment 569-570, 442-449.
[86] Pawar, G., Abdallah, M.E., de Sáa, E., Stuart, H., 2017. Dermal bioaccessibility of flame retardants from ındoor dust and the ınfluence of topically applied cosmetics. Journal of Exposure Science & Environmental Epidemiology 27, 100–105.
[87] Darnerud, P.O., 2003. Toxic effects of brominated flame retardants in man and ın wildlife. Environment International 29, 841-853.
[88] Yamada-Okabe, T., Sakai, H., Kashima, Y., Yamada-Okabe, H., 2005. Modulation at a cellular level of the thyroid hormone receptormediated gene expression by 1,2,5,6,9,10-hexabromocyclododecane (HBCD), 4,4′-diiodobiphenyl (DIB), and nitrofen (NIP). Toxicology Letters 155, 127-133.
[89] Mariussen, E., Fonnum, F., 2003. The effect of brominated flame retardants on neurotransmitter uptake into rat brain synaptosomes and vesicles. Neurochemistry International 43, 533-542.
[90] Graves, W.C., Swigert, J.P. 1997. Hexabromocyclododecane (HBCD): A 96-hour Flow-Through Acute Toxicity Test with The Rainbow Trout (Oncorhynchus Mykiss).
[91] Drottar, K.R., MacGregor, J.A., Krueger, H.O., 2001. Hexabromocyclododecane (HBCD): An Early Life-Stage Toxicity Test with Rainbow Trout (Oncorhynchus Mykiss).
[92] Drottar, K.R., Krueger, H.O., 2000. PFOS: A flow through Life-Cycle Toxicity Test With The Saltwater Mysid (Mysidopsis Bahia), Wildlife International, Ltd., Project, (454A-107).
[93] Roberts, C.A., Swigert, J.P., 1997. Hexabromocyclododecane (HBCD): A 96-Hour Toxicity Test with The Freshwater Alga (Selenastrum Capricornutum), Final report.
[94] Walsh, G.E., Yoder, M.J., McLaughlin, L.L., Lores, E.M., 1987. Responses of marine unicellular algae to brominated organic compounds in six growth media. Ecotoxicology and Environmental Safety 14(3), 215-222.
[95] Desjardins, D., MacGregor, J.A., Krueger, H.O., 2005. Hexabromocyclododecane (HBCD): A 72-Hour Toxicity Test with the Marine Diatom (Skeletonema Costatum) Using A Co-Solvent, Chapter 1.

Ayrıntılar

Birincil Dil

Türkçe

Konular

Çevre Mühendisliği

Bölüm

Derleme

Yazarlar

Fatma Şevval Sönmez
0000-0002-6884-4686
Türkiye

Barış Güzel ^*
0000-0002-6709-2339
Türkiye

Oltan Canlı
0000-0002-2652-844X
Türkiye

Yayımlanma Tarihi

31 Temmuz 2023

Gönderilme Tarihi

22 Eylül 2022

Kabul Tarihi

20 Aralık 2022

Yayımlandığı Sayı

Yıl 2023 Cilt: 6 Sayı: 1

DOI

https://doi.org/10.53410/koufbd.1178809

IZ

https://izlik.org/JA98UU88XY

Kaynak Göster

RIS / Bibtex

APA

Sönmez, F. Ş., Güzel, B., & Canlı, O. (2023). Polibromlu Dibenzo-p-Dioksinler/Furanlar (PBDD/F’lar) ve Hegzabromosiklododekanlar (HBCDD’lar): Kimyasal Oluşum, İzleme, Etki ve Ölçüm. Kocaeli Üniversitesi Fen Bilimleri Dergisi, 6(1), 14-26. https://doi.org/10.53410/koufbd.1178809

AMA

1.Sönmez FŞ, Güzel B, Canlı O. Polibromlu Dibenzo-p-Dioksinler/Furanlar (PBDD/F’lar) ve Hegzabromosiklododekanlar (HBCDD’lar): Kimyasal Oluşum, İzleme, Etki ve Ölçüm. KOUFBD. 2023;6(1):14-26. doi:10.53410/koufbd.1178809

Chicago

Sönmez, Fatma Şevval, Barış Güzel, ve Oltan Canlı. 2023. “Polibromlu Dibenzo-p-Dioksinler/Furanlar (PBDD/F’lar) ve Hegzabromosiklododekanlar (HBCDD’lar): Kimyasal Oluşum, İzleme, Etki ve Ölçüm”. Kocaeli Üniversitesi Fen Bilimleri Dergisi 6 (1): 14-26. https://doi.org/10.53410/koufbd.1178809.

EndNote

Sönmez FŞ, Güzel B, Canlı O (01 Temmuz 2023) Polibromlu Dibenzo-p-Dioksinler/Furanlar (PBDD/F’lar) ve Hegzabromosiklododekanlar (HBCDD’lar): Kimyasal Oluşum, İzleme, Etki ve Ölçüm. Kocaeli Üniversitesi Fen Bilimleri Dergisi 6 1 14–26.

IEEE

[1]F. Ş. Sönmez, B. Güzel, ve O. Canlı, “Polibromlu Dibenzo-p-Dioksinler/Furanlar (PBDD/F’lar) ve Hegzabromosiklododekanlar (HBCDD’lar): Kimyasal Oluşum, İzleme, Etki ve Ölçüm”, KOUFBD, c. 6, sy 1, ss. 14–26, Tem. 2023, doi: 10.53410/koufbd.1178809.

ISNAD

Sönmez, Fatma Şevval - Güzel, Barış - Canlı, Oltan. “Polibromlu Dibenzo-p-Dioksinler/Furanlar (PBDD/F’lar) ve Hegzabromosiklododekanlar (HBCDD’lar): Kimyasal Oluşum, İzleme, Etki ve Ölçüm”. Kocaeli Üniversitesi Fen Bilimleri Dergisi 6/1 (01 Temmuz 2023): 14-26. https://doi.org/10.53410/koufbd.1178809.

JAMA

1.Sönmez FŞ, Güzel B, Canlı O. Polibromlu Dibenzo-p-Dioksinler/Furanlar (PBDD/F’lar) ve Hegzabromosiklododekanlar (HBCDD’lar): Kimyasal Oluşum, İzleme, Etki ve Ölçüm. KOUFBD. 2023;6:14–26.

MLA

Sönmez, Fatma Şevval, vd. “Polibromlu Dibenzo-p-Dioksinler/Furanlar (PBDD/F’lar) ve Hegzabromosiklododekanlar (HBCDD’lar): Kimyasal Oluşum, İzleme, Etki ve Ölçüm”. Kocaeli Üniversitesi Fen Bilimleri Dergisi, c. 6, sy 1, Temmuz 2023, ss. 14-26, doi:10.53410/koufbd.1178809.

Vancouver

1.Fatma Şevval Sönmez, Barış Güzel, Oltan Canlı. Polibromlu Dibenzo-p-Dioksinler/Furanlar (PBDD/F’lar) ve Hegzabromosiklododekanlar (HBCDD’lar): Kimyasal Oluşum, İzleme, Etki ve Ölçüm. KOUFBD. 01 Temmuz 2023;6(1):14-26. doi:10.53410/koufbd.1178809

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