Investıgatıon Of Vitamin B12, Folate And Vitamin DLevels İn Children With Autistic Spectrum Disorder

Abstract

Otistik Spektrum Bozukluğu BulunanÇocuklarda Vitamin B12, Folat ve Vitamin D Seviyelerinin İncelenmesi

Öz

ÖzOtizm spektrum bozukluğu (OSB) bulunan çocuklarda belirgin yiyecek seçiciliği vebazı davranış özellikleri bulunmaktadır. Bunun sonucunda bu çocuklarda besin öğele-ri eksiklikleri gelişebilmektedir. Ayrıca tek karbon metabolizması ve vitamin D,OSB’nun patogenezinde rol oynayabilmektedir. Bu amaçla yapılan incelemede OSB bu-lunan çocuklarda Vitamin B12 ve Vitamin D eksikliği belirgin şekilde saptanmıştır (heriki değer için de p<0.001). Folat düzeylerinde ise anlamlı bir farklılık tespit edilememiş-tir (p:0.487). Ayrıca sözel iletişim yetersizliği ile vitamin B12 ve vitamin D değerleri ara-sında anlamlı olarak negatif  korelasyonlar bulunmuştur (r:-0.234; p:0.042 ve r:-0297;p:0.009 sırasıyla). Bununla birlikte OSB şiddetini gösteren Çocukluk çağı otizm dere-celendirme ölçeği (CARS, Childhood autism rating scale) skoru ile vitamin B12 ve vi-tamin D arasında anlamlı olarak negatif korelasyon bulunmuştur (r:-0.293; p:0.001 ver:-0.320; p<0.001, sırasıyla) .  Buna göre vitamin B12 ve vitamin D, OSB’nin patoge-nezinde rol oynayabilir ve OSB belirtilerinin şiddetlenmesine neden olabilir. Ayrıca OSBbulunan çocuklar sıklıkla vitamin eksiklikleri geliştirebilirler. 

Anahtar Kelimeler

• Otizm Spektrum Bozukluğu,Vitamin B12,Folat,VitaminD,tek karbon metabolizmas

Kaynakça

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