The Effect of Tirofiban on Average Platelet Volumein Patients with Acute Coronary Syndrom

Abstract

Abstract

Introduction: Cardiovascular diseases are known as leading causes of death. The ti-rofiban GPIIb / IIIa receptor antagonist effectively inhibits platelet aggregation. MeanPlatelet Volume is a marker indicating platelet activation. We aimed to evaluate the ef-fect of tirofiban on the mean platelet volume in our study.

Methods:The patients were divided into two groups: the control group treat with 300mg aspirin 600 mg clopidogrel (n: 20) and the other group (tirofiban group n: 56) in addition to these two antiplatelet treatments. Hematological parameters of these two groups were evaluated before and after treatment.

Results:When the mean platelet volume was compared before and after the procedure, it was observed that the mean platelet volume decreased statistically in the tirofiban group. (8,31 ± 1,12; 7,89 ± 0,81 p <0,001).

Conclusion:in our study has been shown that the use of tirofiban in patients withintense thrombus load a positive effect on the reduction of mean platelet volume.

Akut Koroner Sendromlu Hastalarda Tirofibanın Ortalama Trombosit Hacmine Etkisi

Öz

Öz

Giriş: Kardiyovasküler hastalıklar önde gelen ölüm nedenleri olarak bilinmektedir.Tirofiban GPIIb / IIIa reseptör antagonisti olup , trombosit agregasyonunu etkili bir şekilde inhibe eder. Ortalama Trombosit Hacmi trombosit aktivasyonunu gösteren bir markerdir. Çalışmamızda tirofibanın ortalam trombosit hacmine etkisini değerlendirmeği amaçladık.

Yöntem: Çalışmaya tedavisine 300 mg aspirin 600 mg klopidogrel verilen grup (n:20)ve bu ikili antiplatelet tedaviye ek olarak tirofiban eklenen grup (n:56) olmak üzereiki gruba ayrıldı. Bu iki gurubun tedavi öncesi ve sonrası hematolojik parametreleri değerlendirildi. Bulgular: İşlem öncesi ve sonrası ortalam trombosit hacmi karşılaştırıldığında ortalama trombosit hacminin tirofiban verilen gurupta istatistiksel olarak anlamlı şekilde düştüğü izlendi. (8,31±1,12; 7,89±0,81 p<0,001).

Sonuç:Çalışmamızda yoğun trombüs yükü olan hastalarda tirofibanın kullanılmasının ortalama trombosit hacmi nin azalaması üzerine olumlu etkisi olduğu gösterilmiştir.

Anahtar Kelimeler

• Tirofiban,Ortalama Trombosit Hacmi

Kaynakça

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