Diyet ve Pankreas Kanseri

Yıl 2016, Cilt: 8 Sayı: 4, 3 - 6, 29.07.2016

Türkan Öztürk Topcu

Öz

Pankreas kanseri çok iyi bilindiği gibi prognozu kötü ve sağkalım süresi kısa olan

bir kanser türüdür. Bu kanser türünün erken evrede tanı almasının zor olması, kemoterapi

ve radyoterapi tedavilerine dirençli olmasından dolayı agresif bir hastalıktır. Bu nedenlerden

dolayı pankreas kanserinin nedeninin ve etkili bir tedavi yönteminin bulunması

önemlidir. Fazla kilolu olma, diyabet, sigara ve diyet tanımlanan bazı risk faktörlerindendir.

Sağlıklı yaşama, düzenli egzersiz, sigara içmeme, ideal kiloyu koruma, düşük

yağ ve şeker içeren diyetler pankreas kanseri ve daha birçok kanseri önleme de etkili

olduğu gösterilmiştir. Taze meyve ve sebze tüketimi pankreas kanseri gelişim riskini

azaltmaktadır. Son çalışmalarda kabuklu yemişlerin tüketiminin koruyucu etki gösterdiği

saptanmıştır. Diyetin pankreas kanserine karşı etkili olduğunu gösteren çalışmalara

rağmen bu alanda çok daha fazla araştırmaya ihtiyaç vardır. Bu çalışmada diyet alışkanlığı

ve pankreas kanseri arasındaki ilişkiyi tartıştık.

Anahtar Kelimeler

pankreas kanseri, kanserden korunma, diyet

Kaynakça

• 1. Li Y, Go VL, Sarkar FH. The Role of Nutraceuticals in Pancreatic Cancer Prevention and Therapy: Targeting Cellular Signaling, MicroRNAs, and Epigenome. Pancreas. 2015;44(1):1-10. 2. Li HY, Cui ZM, Chen J, Guo XZ, Li YY. Pancreatic cancer: diagnosis and treatments. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 2015;36(3):1375-84. 3. Stan SD, Singh SV, Brand RE. Chemoprevention strategies for pancreatic cancer. Nature reviews Gastroenterology & hepatology. 2010;7(6):347-56. 4. Magruder JT, Elahi D, Andersen DK. Diabetes and pancreatic cancer: chicken or egg? Pancreas. 2011;40(3):339-51. 5. Harris DM, Srihari P, Go VL. Pancreatic cancer prevention and the 2010 Dietary Guidelines for Americans. Pancreas. 2011;40(5):641-3. 6. Bidoli E, Pelucchi C, Zucchetto A, Negri E, Dal Maso L, Polesel J, et al. Fiber intake and pancreatic cancer risk: a case-control study. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2012;23(1):264-8. 7. Bao Y, Hu FB, Giovannucci EL, Wolpin BM, Stampfer MJ, Willett WC, et al. Nut consumption and risk of pancreatic cancer in women. British journal of cancer. 2013;109(11):2911-6. 8. Garrido-Laguna I, Hidalgo M. Pancreatic cancer: from state- of-the-art treatments to promising novel therapies. Nature reviews Clinical oncology. 2015;12(6):319-34. 9. Mohammed A, Janakiram NB, Lightfoot S, Gali H, Vibhudutta A, Rao CV. Early detection and prevention of pancreatic cancer: use of genetically engineered mouse models and advanced imaging technologies. Current medicinal chemistry. 2012;19(22):3701-13. www.kliniktipdergisi.com 5 10. Provenzano PP, Cuevas C, Chang AE, Goel VK, Von Hoff DD, Hingorani SR. Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer cell. 2012;21(3):418-29. 11. Schmitz KH, Neuhouser ML, Agurs-Collins T, Zanetti KA, Cadmus- Bertram L, Dean LT, et al. Impact of obesity on cancer survivorship and the potential relevance of race and ethnicity. Journal of the National Cancer Institute. 2013;105(18):1344-54. 12. Azvolinsky A. Cancer risk: the fat tissue-BMI-obesity connection. Journal of the National Cancer Institute. 2014;106(4):dju100. 13. Frossard JL, Lescuyer P, Pastor CM. Experimental evidence of obesity as a risk factor for severe acute pancreatitis. World journal of gastroenterology. 2009;15(42):5260-5. 14. Navina S, Acharya C, DeLany JP, Orlichenko LS, Baty CJ, Shiva SS, et al. Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity. Science translational medicine. 2011;3(107):107ra10. 15. Kolodecik T, Shugrue C, Ashat M, Thrower EC. Risk factors for pancreatic cancer: underlying mechanisms and potential targets. Frontiers in physiology. 2013;4:415. 16. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132(1):27-42. 17. Gukovsky I, Li N, Todoric J, Gukovskaya A, Karin M. Inflammation, autophagy, and obesity: common features in the pathogenesis of pancreatitis and pancreatic cancer. Gastroenterology. 2013;144(6):1199-209 e4. 18. Baenke F, Peck B, Miess H, Schulze A. Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development. Disease models & mechanisms. 2013;6(6):1353-63. 19. Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell. 2010;140(1):49-61. 20. Louie SM, Roberts LS, Mulvihill MM, Luo K, Nomura DK. Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids. Biochimica et biophysica acta. 2013;1831(10):1566-72. 21. Kuemmerle NB, Rysman E, Lombardo PS, Flanagan AJ, Lipe BC, Wells WA, et al. Lipoprotein lipase links dietary fat to solid tumor cell proliferation. Molecular cancer therapeutics. 2011;10(3):427-36. 22. Johansen D, Stocks T, Jonsson H, Lindkvist B, Bjorge T, Concin H, et al. Metabolic factors and the risk of pancreatic cancer: a prospective analysis of almost 580,000 men and women in the Metabolic Syndrome and Cancer Project. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2010;19(9):2307-17. 23. Rebours V, Gaujoux S, d'Assignies G, Sauvanet A, Ruszniewski P, Levy P, et al. Obesity and Fatty Pancreatic Infiltration Are Risk Factors for Pancreatic Precancerous Lesions (PanIN). Clinical cancer research : an official journal of the American Association for Cancer Research. 2015;21(15):3522-8. 24. Arslan AA, Helzlsouer KJ, Kooperberg C, Shu XO, Steplowski E, Bueno-de-Mesquita HB, et al. Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan). Archives of internal medicine. 2010;170(9):791-802. 25. Li D, Morris JS, Liu J, Hassan MM, Day RS, Bondy ML, et al. Body mass index and risk, age of onset, and survival in patients with pancreatic cancer. Jama. 2009;301(24):2553-62. 26. Genkinger JM, Spiegelman D, Anderson KE, Bernstein L, van den Brandt PA, Calle EE, et al. A pooled analysis of 14 cohort studies of anthropometric factors and pancreatic cancer risk. International journal of cancer Journal international du cancer. 2011;129(7):1708-17. 27. Hori M, Kitahashi T, Imai T, Ishigamori R, Takasu S, Mutoh M, et al. Enhancement of carcinogenesis and fatty infiltration in the pancreas in N-nitrosobis(2-oxopropyl)amine-treated hamsters by high-fat diet. Pancreas. 2011;40(8):1234-40. 28. La Vecchia C. Association between Mediterranean dietary patterns and cancer risk. Nutrition reviews. 2009;67 Suppl 1:S126-9. 29. Liu RH. Potential synergy of phytochemicals in cancer prevention: mechanism of action. The Journal of nutrition. 2004;134(12 Suppl):3479S-85S. 30. Liu RH. Dietary bioactive compounds and their health implications. Journal of food science. 2013;78 Suppl 1:A18-25. 31. Aad G, Abbott B, Abdallah J, Abdinov O, Aben R, Abolins M, et al. Combined Measurement of the Higgs Boson Mass in pp Collisions at sqrt[s]=7 and 8 TeV with the ATLAS and CMS Experiments. Physical review letters. 2015;114(19):191803. 32. Hasima N, Ozpolat B. Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer. Cell death & disease. 2014;5:e1509. 33. Barreto SG, Neale RE. Vitamin D and pancreatic cancer. Cancer letters. 2015;368(1):1-6. 34. Sherman MH, Yu RT, Engle DD, Ding N, Atkins AR, Tiriac H, et al. Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy. Cell. 2014;159(1):80-93.