Topical NSAIDs in the Treatment of Osteoarthritis

Yıl 2017, Cilt: 9 Sayı: 4, 6 - 11, 26.07.2017

Prof. Dr. N. Emel Lüleci

Öz

Abstract

Osteoarthritis, the most common chronic disease in the joints, resulting destruction.It is the most common cause of pain and loss of function in society. Overall, as manyas 40% of those aged over 65 in the community may have symptomatic OA. The aimsof the treatment in OA are reducing joint pain and stiffness, maintaining and improvingjoint mobility, reducing physical disability and handicap, improving health related quality of life, limiting the progression of joint damage and educating patients about the nature of the disorder and its progression.  The recommended pharmacological modalities include acetaminophen, non-steroidal anti-inflammatory drugs, drugs and capsaicin,intraarticular injections of corticosteroids and hyaluronates, symptomatic slow acting drugsfor osteoarthritis and opioid analgesics.  In this review, current effectivneess of topical NSAİDs’  will be discussed in osteoarthritis.

Anahtar Kelimeler

Osteoarthritis, topical nonsteroid anti-inflammatorydrugs, treatment guidelines

Osteoartrit Tedavisinde Topikal NSAİİ’lerin Yeri

Öz

Öz

Osteoartrit (OA), eklemlerde en sık rastlanan, destruksiyonla sonuçlanan kronik birhastalıktır. Eklemlerdeki ağrı ve fonksiyon kaybının toplumdaki en sık nedenidir. Genel olarak toplumda 65 yaş üzeri bireylerde semptomatik OA %40’a varan oranlarda görülebilir. OA’da tedavinin amaçları eklem ağrısı ve tutukluğunu azaltmak, eklem mobilitesini korumak ve iyileştirmek, fiziksel kısıtlılıkları ve engelliliği azaltmak, yaşam ka-litesini arttırmak, eklem hasarının ilerlemesini önlemek ve hastalığın seyri ve sonuçları konusunda hastayı eğitmektir. Önerilen farmakolojik modaliteler ise asetaminofen, nonsteroid antiinflamatuvar ilaçlar, topikal antiinflamatuvar ilaçlar ve kapsaisin, intraartiküler kortikosteroid ve hiyalüronatlar, semptomatik yavaş etkili OA ilaçları ve opioid analjezikleri içerir. Bu derlemede OA li hastalarda topikal NSAİ ilaçların etkinliği üzerinde duracağız

Anahtar Kelimeler

Osteoarthritis, topikal nonsteroid antiinflamatuar ilaçlar, tedavi klavuzları

Kaynakça

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