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To Soft Tissue Injuries Approach and Place of Oral Nonsteroid Antiinflammatory Drugs in Treatment

Yıl 2017, Cilt: 9 Sayı: 6, 0 - 0, 27.11.2017

Öz

Abstract

Soft tissue injuries of the upper or lower extremities are common in general population.  When mechanical load on soft tissues exceeds their tensil strenght, tissue injuryoccur. Sport activities, high physical strain, or prolonged repetetive physical factors cause ligament, tendon, tendon sheat, bursae, nerve and muscle injuries. Local tissue injuryand  inflammation causes swelling and pain; limits mobility and functions. The objective of the initial treatment of the acut soft tissue injury is the control of the inflammation and pain. Rest, ice, compression, and elevation (RICE) protocol is the basic principle of the initial treatment but functional treatment approach is more effective than theRICE protocol because progressive mechanical loads cause the functional healing of theinjured tissues.Nonsteroidal anti-inflammatory drugs are commonly prescribed for soft tissue injuries because of their anti-inflammatory and analgesic effects, but they have high adver-se effect profile.  Physical agents  can control the pain; exercise and rehabilitation protocols should be used for the functional gains for the patients with soft tissue injury.

Kaynakça

  • Kaynaklar 1.Oral A, Ilieva EM, Küçükdeveci AA, Varela E, Valero R, Ber-teanu M, Christodoulou N; UEMS-PRM Section ProfessionalPractice Committee. Local soft tissue musculoskeletal disor-ders and injuries. The role of physical and rehabilitation me-dicine physicians. The European perspective based on the bestevidence. A paper by the UEMS-PRM Section ProfessionalPractice Committee. Eur J Phys Rehabil Med. 2013;49(5):727-4 2. PubMed PMID: 241452312.Goldgrub R, Côté P, Sutton D, Wong JJ, Yu H, Randhawa K,et al. The effectiveness of multimodal care for the managementof soft tissue injuries of The shoulder: a systematic review bythe Ontario protocol for traffic injury Management (OPTIMa)collaboration. J Manipulative Physiol Ther 2016;39:121-139. 3.Sutton D, Gross DP, Côté P, Randhawa K, Yu H, Wong JJ,et al. Multimodal care for the management of musculoskele-tal disorders of the elbow, forearm, wrist and hand: a syste-matic review by the Ontario Protocol for Traffic Injury Ma-nagement (OPTIMa)Collaboration. Chiropr Man Therap.2016;24:8. 4.Sutton DA, Nordin M, Côté P, Randhawa K, Yu H, Wong JJ,et al. The effectiveness of multimodal care for soft tissue in-juries of the lower extremity: a systematic review by the On-tario Protocol for Traffic injury management (OPTIMA) col-laboration. J Manipulative Physiol Ther 2016;39:95-109. 5.Lambers K, Ootes D, Ring D. Incidence of patients with lo-wer extremity injuries presenting to US emergency departmentsby anatomic region, disease category, and age. Clin OrthopRelat Res 2012;470:284-90. 6.Ootes D, Lambers KT, Ring DC. The epidemiology of upperextremity injuries presenting to the emergency department inthe United States. Hand (N Y) 2012;7:18-22. 7.Hill CL, Gill TK, Shanahan EM, Taylor AW. Prevalence andcorrelates of shoulder pain and stiffness in a populationba-sed study: the North West Adelaide Health Study. Int J Rhe-um Dis 2010;13:215-22. 8.Piper S, Shearer HM, Cote P, Wong JJ, Yu H, VaratharajanS. The effectiveness of soft-tissue therapy for the managementof musculoskeletal disorders and injuries of the upper and lo-wer extremities: A systematic review by the Ontario Protocolfor Traffic Injury management (OPTIMa) collaboration.Manual Therapy 2016; 21: 18-34. 9.Dale AM, Harris-Adamson C, Rempel D, Gerr F, HegmannK, Silverstein B, et al. Prevalence and incidence of carpal tun-nel syndrome in US working populations: pooled analysis ofsix prospective studies. Scand J Work Environ Health2013;39:495-505. 10.Shiri R, Viikari-Juntura E, Varonen H, Heliovaara M. Pre-valence and determinants of lateral and medial epicondylitis:a population study. Am J Epidemiol. 2006;164:1065–74. 11.Descatha A, Dale AM, Jaegers L, Herquelot E, Evanoff B. Self-reported physical exposure association with medial and la-teral epicondylitis incidence in a large longitudinal study. Oc-cup Environ Med. 2013;7:670–3. 12.Mondelli M, Giannini F, Ballerini M, Ginanneschi F, Mar-torelli E. Incidence of ulnar neuropathy at the elbow in the pro-vince of Siena (Italy). J Neurol Sci. 2005;234(1–2):5–10. 13.Gregg EW, Sorlie P, Paulose-Ram R, Gu Q, Eberhardt MS,Wolz M, et al. Prevalence of lower-extremity disease in the USadult population >40 years of age with and without diabe-tes: 1999-2000 National health and nutrition examination sur-vey. Diabetes Care 2004;27:1591-7. 14.de Jonge S, van den Berg C, de Vos RJ, van der Heide HJ, WeirA, Verhaar JA, et al. Incidence of midportion Achilles tendi-nopathy in the general population. Br J Sports Med2011;45:1026-8. 15.Petersen W, Rembitzki IV, Koppenburg AG, Ellermann A, Lie-bau C, Bruggemann GP, et al. Treatment of acute ankle liga-ment injuries: a systematic review. Arch Orthop Trauma Surg2013;133:1129-41. 16.Ferran NA, Maffulli N. Epidemiology of sprains of the late-ral ankle ligament complex. Foot Ankle Clin 2006;11:659-62. 17.Riddle DL, Schappert SM. Volume of ambulatory care visitsand patterns of care for patients diagnosed with plantar fas-ciitis: a national study of medical doctors. Foot Ankle Int2004;25:303-10. 18.Tong KB, Furia J. Economic burden of plantar fasciitis tre-atment in the United States. Am J Orthop (Belle Mead NJ)2010;39:227-31. 19.Barlow Y, Willoughby J. Pathophysiology of soft tissue repa-ir. Br Med Bull 1992;48: 698-711. 20.Almekinders LC, Gilbert JA. Healing of experimental musc-le strains and the effects of nonsteroidal antiinflammatory me-dication. Am J Sports Med 1986; 14:303-308. 21.Sloan J. Soft tissue injuries: introduction and basic princip-les. Emerg Med J. 2008;25:33-7.Review. 22.Bleakley, CM, Glasgow, P, MacAuley, DC. PRICE needs up-dating, should we call the POLICE? British Journal ofSports Medicine, 2012;46: 220–221. 23.Kerkhoffs GM, van den Bekerom M, Elders LA, et al. Di-agnosis, treatment and prevention of ankle sprains: an evi-dence-based clinical guideline. Br J Sports Med2012;46:854-60. 24.Seah R, Mani-Babu S. Managing ankle sprains in primary care:what is best practice? A systematic review of the last 10 ye-ars of evidence. Br Med Bull 2011;97: 105-35. 25.van Rijn RM, van Ochten J, Luijsterburg PA, van Middelko-op M, Koes BW, Bierma-Zeinstra SM. Effectiveness of addi-tional supervised exercises compared with conventional tre-atment alone in patients with acute lateral ankle sprains: syste-matic review. BMJ 2010;341:c5688 .26.O'Driscoll J, Delahunt E. Neuromuscular training to enhan-ce sensorimotor and functional deficits in subjects withchronic ankle instability: a systematic review and best eviden-ce synthesis. Sports Med Arthrosc Rehabil Ther Technol2011;3:19. 27.Habets B, van Cingel RE. Eccentric exercise training in chro-nic mid-portion Achilles tendinopathy: a systematic review ondifferent protocols. Scand J Med Sci Sports 2014;25:3-15. 28.Woitzik E, Jocobs C, Wong JJ, Cote P, Shearer HM, Rand-hawa K, et al. The effectiveness of exercise on recovery andclinical outcomes of soft tissue injuries of the leg, ankle, andfoot: A systematic review by the Ontario Protocol for TrafficInjury Management (OPTIMa) Collaboration. Manual The-rapy. 2015;20: 633-645. 29.Brown CK, Southerst D, Côté P, Shearer HM, Randhawa K,Wong JJ, et al. The effectiveness of exercise on recovery andclinical outcomes in patients with soft tissue injuries of the hip,thigh, or Knee: a systematic review by the Ontario Protocolfor Traffic Injury Management (optima) collaboration. J Ma-nipulative Physiol Ther 2016;39:110-120. 30.Mehallo CJ, Drezner JA, Bytomski JR. Practical management:nonsteroidal antiinflammatory drug (NSAID) use in athleticinjuries. Clin J of Sport Med 2006;16:170–4. 31.Lionberger DR, Brennan MJ. Topical nonsteroidal anti-inflam-matory drugs for the treatment of pain due to soft tissue in-jury: diclofenac epolamine topical patch. Journal of Pain Re-search 2010:3 223–233. 32.Brater DC. Effects of nonsteroidal anti-inflammatory drugs onrenal function: focus on cyclooxygenase-2-selective inhibiti-on. Am J Med. 1999;107(6A):S65–S70; discussion S70–S71. 33.Cannon CP, Curtis SP, FitzGerald GA, et al; for the MEDALSteering Committee. Cardiovascular outcomes with etorico-xib and diclofenac in patients with osteoarthritis and rheuma-toid arthritis in the Multinational Etoricoxib and DiclofenacArthritis Longterm (MEDAL) programme: a randomised com-parison. Lancet. 2006;368:1771–1781 .34.Busti AJ, Hooper JS, Amaya CJ, Kazi S. Effects of periope-rative antiinflammatory and immunomodulating therapy onsurgical wound healing. Pharmacotherapy 2005;25:1566–1591. 35.Chen MR, Dragoo JL. The effect of nonsteroidal anti-inflam-matory drugs on tissue healing. Knee Surg Sports TraumatolArthrosc. 2013 Mar;21:540-9. Review. 36.Stovitz SD, Johnson RJ. NSAIDs and musculoskeletal treat-ment: what is the clinical evidence? Phys Sportsmed2003;31:35–52. 37.Hertel J. Oral non-steroidal anti-inflammatory drugs versusother oral analgesic agents for acute soft tissue injury. J AthlTrain 1997;32:350–8. 38.Hinz B, Renner B, Brune K. Drug insight: cyclo-oxygenase-2 inhibitors – a critical appraisal. Nat Clin Pract Rheumatol2007;3:552-60. 39.Gierer P, Mittlmeier T, Bordel R, et al. Selective cyclooxyge-nase-2 inhibition reverses microcirculatory and inflammatorysequelae of closed soft-tissue trauma in an animal model. JBone Joint Surg Am 2005;87:153-60. 40.Jones P and Lamdin R. Oral cyclo-oxygenase 2 inhibitorsversus other oral analgesics for acute soft tissue injury. Syste-matic Review and Meta-Analysis. Clin Drug Investig2010;30:419-437. 41.van den Bekerom MPJ. No difference in pain, swelling or func-tion with NSAIDs compared with paracetamol for soft tissue in-jury (Commentary on: Jones P, Dalziel SR, Lamdin R, et al. Oralnonsteroidal anti-inflammatory drugs versus other oral anal-gesic agents for acute soft tissue injury. Cochrane Database SystRev 2015;7:CD007789), Evid Based Nurs 2016 19: 21.

Yumuşak Doku Yaralanmalarına Yaklaşım ve Tedavide Oral Nonsteroid Antiinflamatuvar İlaçların Yeri

Yıl 2017, Cilt: 9 Sayı: 6, 0 - 0, 27.11.2017

Öz

Öz

Üst ve alt ekstremite yumuşak doku yaralanmaları toplumda sık rastlanan rahatsızlıklardır. Yumuşak dokulara mekanik yüklenme bu dokuların gerilebilme, karşı koyabilme güçlerinin üzerindeyse doku hasarı gelişir. Sportif aktiviteler sırasında, büyük fiziksel zorlanmalarda veya uzun süre tekrarlayan fiziksel travmalar olduğunda ligaman, tendon, tendon kılıfı, bursa, sinir ve kaslarda yaralanma olur. Lokal doku hasarı ardındangelişen inflamasyon şişlik ve ağrıya neden olur; mobilite kısıtlanır, fonksiyonlar etkilenir. Akut yumuşak doku yaralanmasının erken dönem tedavisinin amacı ağrı ve infla-masyonun kontroludur. RICE (Rest-istirahat, Ice-buz, Compression-kompresyon, Elevation-elevasyon) protokolu ilk tedavinin temel prensibidir; ancak progressif mekanikyükler yaralanmış dokuların fonksiyonel iyileşmesini sağladığından, fonksiyonel tedavi yaklaşımı RICE protokolundan daha etkindir.   Yumuşak doku yaralanmalarında antiinflammatuvar ve analjezik etkileri nedeniyle nonsteroid antiinflammatuvar ilaçlar yaygın olarak reçetelenir, ancak yan etki profilleri yüksektir. Fiziksel ajanlar da ağrı kont-rolu sağlayabilir, egzersiz ve rehabilitasyon uygulamaları yumuşak doku yaralanmalı hastalarda fonksiyonel kazançların sağlanması için kullanılmalıdır.

Kaynakça

  • Kaynaklar 1.Oral A, Ilieva EM, Küçükdeveci AA, Varela E, Valero R, Ber-teanu M, Christodoulou N; UEMS-PRM Section ProfessionalPractice Committee. Local soft tissue musculoskeletal disor-ders and injuries. The role of physical and rehabilitation me-dicine physicians. The European perspective based on the bestevidence. A paper by the UEMS-PRM Section ProfessionalPractice Committee. Eur J Phys Rehabil Med. 2013;49(5):727-4 2. PubMed PMID: 241452312.Goldgrub R, Côté P, Sutton D, Wong JJ, Yu H, Randhawa K,et al. The effectiveness of multimodal care for the managementof soft tissue injuries of The shoulder: a systematic review bythe Ontario protocol for traffic injury Management (OPTIMa)collaboration. J Manipulative Physiol Ther 2016;39:121-139. 3.Sutton D, Gross DP, Côté P, Randhawa K, Yu H, Wong JJ,et al. Multimodal care for the management of musculoskele-tal disorders of the elbow, forearm, wrist and hand: a syste-matic review by the Ontario Protocol for Traffic Injury Ma-nagement (OPTIMa)Collaboration. Chiropr Man Therap.2016;24:8. 4.Sutton DA, Nordin M, Côté P, Randhawa K, Yu H, Wong JJ,et al. The effectiveness of multimodal care for soft tissue in-juries of the lower extremity: a systematic review by the On-tario Protocol for Traffic injury management (OPTIMA) col-laboration. J Manipulative Physiol Ther 2016;39:95-109. 5.Lambers K, Ootes D, Ring D. Incidence of patients with lo-wer extremity injuries presenting to US emergency departmentsby anatomic region, disease category, and age. Clin OrthopRelat Res 2012;470:284-90. 6.Ootes D, Lambers KT, Ring DC. The epidemiology of upperextremity injuries presenting to the emergency department inthe United States. Hand (N Y) 2012;7:18-22. 7.Hill CL, Gill TK, Shanahan EM, Taylor AW. Prevalence andcorrelates of shoulder pain and stiffness in a populationba-sed study: the North West Adelaide Health Study. Int J Rhe-um Dis 2010;13:215-22. 8.Piper S, Shearer HM, Cote P, Wong JJ, Yu H, VaratharajanS. The effectiveness of soft-tissue therapy for the managementof musculoskeletal disorders and injuries of the upper and lo-wer extremities: A systematic review by the Ontario Protocolfor Traffic Injury management (OPTIMa) collaboration.Manual Therapy 2016; 21: 18-34. 9.Dale AM, Harris-Adamson C, Rempel D, Gerr F, HegmannK, Silverstein B, et al. Prevalence and incidence of carpal tun-nel syndrome in US working populations: pooled analysis ofsix prospective studies. Scand J Work Environ Health2013;39:495-505. 10.Shiri R, Viikari-Juntura E, Varonen H, Heliovaara M. Pre-valence and determinants of lateral and medial epicondylitis:a population study. Am J Epidemiol. 2006;164:1065–74. 11.Descatha A, Dale AM, Jaegers L, Herquelot E, Evanoff B. Self-reported physical exposure association with medial and la-teral epicondylitis incidence in a large longitudinal study. Oc-cup Environ Med. 2013;7:670–3. 12.Mondelli M, Giannini F, Ballerini M, Ginanneschi F, Mar-torelli E. Incidence of ulnar neuropathy at the elbow in the pro-vince of Siena (Italy). J Neurol Sci. 2005;234(1–2):5–10. 13.Gregg EW, Sorlie P, Paulose-Ram R, Gu Q, Eberhardt MS,Wolz M, et al. Prevalence of lower-extremity disease in the USadult population >40 years of age with and without diabe-tes: 1999-2000 National health and nutrition examination sur-vey. Diabetes Care 2004;27:1591-7. 14.de Jonge S, van den Berg C, de Vos RJ, van der Heide HJ, WeirA, Verhaar JA, et al. Incidence of midportion Achilles tendi-nopathy in the general population. Br J Sports Med2011;45:1026-8. 15.Petersen W, Rembitzki IV, Koppenburg AG, Ellermann A, Lie-bau C, Bruggemann GP, et al. Treatment of acute ankle liga-ment injuries: a systematic review. Arch Orthop Trauma Surg2013;133:1129-41. 16.Ferran NA, Maffulli N. Epidemiology of sprains of the late-ral ankle ligament complex. Foot Ankle Clin 2006;11:659-62. 17.Riddle DL, Schappert SM. Volume of ambulatory care visitsand patterns of care for patients diagnosed with plantar fas-ciitis: a national study of medical doctors. Foot Ankle Int2004;25:303-10. 18.Tong KB, Furia J. Economic burden of plantar fasciitis tre-atment in the United States. Am J Orthop (Belle Mead NJ)2010;39:227-31. 19.Barlow Y, Willoughby J. Pathophysiology of soft tissue repa-ir. Br Med Bull 1992;48: 698-711. 20.Almekinders LC, Gilbert JA. Healing of experimental musc-le strains and the effects of nonsteroidal antiinflammatory me-dication. Am J Sports Med 1986; 14:303-308. 21.Sloan J. Soft tissue injuries: introduction and basic princip-les. Emerg Med J. 2008;25:33-7.Review. 22.Bleakley, CM, Glasgow, P, MacAuley, DC. PRICE needs up-dating, should we call the POLICE? British Journal ofSports Medicine, 2012;46: 220–221. 23.Kerkhoffs GM, van den Bekerom M, Elders LA, et al. Di-agnosis, treatment and prevention of ankle sprains: an evi-dence-based clinical guideline. Br J Sports Med2012;46:854-60. 24.Seah R, Mani-Babu S. Managing ankle sprains in primary care:what is best practice? A systematic review of the last 10 ye-ars of evidence. Br Med Bull 2011;97: 105-35. 25.van Rijn RM, van Ochten J, Luijsterburg PA, van Middelko-op M, Koes BW, Bierma-Zeinstra SM. Effectiveness of addi-tional supervised exercises compared with conventional tre-atment alone in patients with acute lateral ankle sprains: syste-matic review. BMJ 2010;341:c5688 .26.O'Driscoll J, Delahunt E. Neuromuscular training to enhan-ce sensorimotor and functional deficits in subjects withchronic ankle instability: a systematic review and best eviden-ce synthesis. Sports Med Arthrosc Rehabil Ther Technol2011;3:19. 27.Habets B, van Cingel RE. Eccentric exercise training in chro-nic mid-portion Achilles tendinopathy: a systematic review ondifferent protocols. Scand J Med Sci Sports 2014;25:3-15. 28.Woitzik E, Jocobs C, Wong JJ, Cote P, Shearer HM, Rand-hawa K, et al. The effectiveness of exercise on recovery andclinical outcomes of soft tissue injuries of the leg, ankle, andfoot: A systematic review by the Ontario Protocol for TrafficInjury Management (OPTIMa) Collaboration. Manual The-rapy. 2015;20: 633-645. 29.Brown CK, Southerst D, Côté P, Shearer HM, Randhawa K,Wong JJ, et al. The effectiveness of exercise on recovery andclinical outcomes in patients with soft tissue injuries of the hip,thigh, or Knee: a systematic review by the Ontario Protocolfor Traffic Injury Management (optima) collaboration. J Ma-nipulative Physiol Ther 2016;39:110-120. 30.Mehallo CJ, Drezner JA, Bytomski JR. Practical management:nonsteroidal antiinflammatory drug (NSAID) use in athleticinjuries. Clin J of Sport Med 2006;16:170–4. 31.Lionberger DR, Brennan MJ. Topical nonsteroidal anti-inflam-matory drugs for the treatment of pain due to soft tissue in-jury: diclofenac epolamine topical patch. Journal of Pain Re-search 2010:3 223–233. 32.Brater DC. Effects of nonsteroidal anti-inflammatory drugs onrenal function: focus on cyclooxygenase-2-selective inhibiti-on. Am J Med. 1999;107(6A):S65–S70; discussion S70–S71. 33.Cannon CP, Curtis SP, FitzGerald GA, et al; for the MEDALSteering Committee. Cardiovascular outcomes with etorico-xib and diclofenac in patients with osteoarthritis and rheuma-toid arthritis in the Multinational Etoricoxib and DiclofenacArthritis Longterm (MEDAL) programme: a randomised com-parison. Lancet. 2006;368:1771–1781 .34.Busti AJ, Hooper JS, Amaya CJ, Kazi S. Effects of periope-rative antiinflammatory and immunomodulating therapy onsurgical wound healing. Pharmacotherapy 2005;25:1566–1591. 35.Chen MR, Dragoo JL. The effect of nonsteroidal anti-inflam-matory drugs on tissue healing. Knee Surg Sports TraumatolArthrosc. 2013 Mar;21:540-9. Review. 36.Stovitz SD, Johnson RJ. NSAIDs and musculoskeletal treat-ment: what is the clinical evidence? Phys Sportsmed2003;31:35–52. 37.Hertel J. Oral non-steroidal anti-inflammatory drugs versusother oral analgesic agents for acute soft tissue injury. J AthlTrain 1997;32:350–8. 38.Hinz B, Renner B, Brune K. Drug insight: cyclo-oxygenase-2 inhibitors – a critical appraisal. Nat Clin Pract Rheumatol2007;3:552-60. 39.Gierer P, Mittlmeier T, Bordel R, et al. Selective cyclooxyge-nase-2 inhibition reverses microcirculatory and inflammatorysequelae of closed soft-tissue trauma in an animal model. JBone Joint Surg Am 2005;87:153-60. 40.Jones P and Lamdin R. Oral cyclo-oxygenase 2 inhibitorsversus other oral analgesics for acute soft tissue injury. Syste-matic Review and Meta-Analysis. Clin Drug Investig2010;30:419-437. 41.van den Bekerom MPJ. No difference in pain, swelling or func-tion with NSAIDs compared with paracetamol for soft tissue in-jury (Commentary on: Jones P, Dalziel SR, Lamdin R, et al. Oralnonsteroidal anti-inflammatory drugs versus other oral anal-gesic agents for acute soft tissue injury. Cochrane Database SystRev 2015;7:CD007789), Evid Based Nurs 2016 19: 21.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm makaleler
Yazarlar

Ayşe Yalıman Bu kişi benim

Yayımlanma Tarihi 27 Kasım 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 9 Sayı: 6

Kaynak Göster

APA Yalıman, A. (2017). Yumuşak Doku Yaralanmalarına Yaklaşım ve Tedavide Oral Nonsteroid Antiinflamatuvar İlaçların Yeri. Klinik Tıp Aile Hekimliği, 9(6).
AMA Yalıman A. Yumuşak Doku Yaralanmalarına Yaklaşım ve Tedavide Oral Nonsteroid Antiinflamatuvar İlaçların Yeri. Aile Hekimliği. Kasım 2017;9(6).
Chicago Yalıman, Ayşe. “Yumuşak Doku Yaralanmalarına Yaklaşım Ve Tedavide Oral Nonsteroid Antiinflamatuvar İlaçların Yeri”. Klinik Tıp Aile Hekimliği 9, sy. 6 (Kasım 2017).
EndNote Yalıman A (01 Kasım 2017) Yumuşak Doku Yaralanmalarına Yaklaşım ve Tedavide Oral Nonsteroid Antiinflamatuvar İlaçların Yeri. Klinik Tıp Aile Hekimliği 9 6
IEEE A. Yalıman, “Yumuşak Doku Yaralanmalarına Yaklaşım ve Tedavide Oral Nonsteroid Antiinflamatuvar İlaçların Yeri”, Aile Hekimliği, c. 9, sy. 6, 2017.
ISNAD Yalıman, Ayşe. “Yumuşak Doku Yaralanmalarına Yaklaşım Ve Tedavide Oral Nonsteroid Antiinflamatuvar İlaçların Yeri”. Klinik Tıp Aile Hekimliği 9/6 (Kasım 2017).
JAMA Yalıman A. Yumuşak Doku Yaralanmalarına Yaklaşım ve Tedavide Oral Nonsteroid Antiinflamatuvar İlaçların Yeri. Aile Hekimliği. 2017;9.
MLA Yalıman, Ayşe. “Yumuşak Doku Yaralanmalarına Yaklaşım Ve Tedavide Oral Nonsteroid Antiinflamatuvar İlaçların Yeri”. Klinik Tıp Aile Hekimliği, c. 9, sy. 6, 2017.
Vancouver Yalıman A. Yumuşak Doku Yaralanmalarına Yaklaşım ve Tedavide Oral Nonsteroid Antiinflamatuvar İlaçların Yeri. Aile Hekimliği. 2017;9(6).