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Tamoksifenle Tedavi Edilen Meme Kanser Hastalarında CYP 2D6 Genetik Polimorfizminin Önemi

Yıl 2018, Cilt: 6 Sayı: 2, 30 - 39, 04.02.2018

Öz

Öz

Tamoksifen östrojen reseptör pozitif meme kanser hastalarının tedavisinin temel taşını oluşturmaktadır. Tamoksifenin etkinliği biyotransformasyonuna bağımlıdır. Biyotransformasyonu baskın olarak CYP 2D6 izoformu tarafından gerçekleştirilerek, tamoksifen aktif metaboliti olan endoksifene dönüştürülmektedir. Hem genetik hem de çevresel faktörler CYP 2D6 enzim aktivitesini değiştirebilmekte, bu durumda aktif tamoksifen metabolitlerinin konsantrasyonlarını direkt olarak etkileyebilmektedir. Çok sayıda çalışmada, CYP 2D6 genetik varyantlarının adjuvant tamoksifenle tedavi edilen hastaların klinik sonuçlarını etkileyebileceği gösterilmiştir. Kişiye özel tedavi uygulamalarında, CYP 2D6 genotipleri ve TAM tedavisinin klinik yanıtı arasındaki bağlantı özellikle meme kanser hastalarında yoğun bir şekilde araştırılmaktadır. Derlememizde tamoksifenin tedavi yanıtıyla ilişkilendirilen CYP 2D6 genetik polimorfizminin moleküler dinamiğini ve klinikteki önemini özetlemeye çalıştık. Bu bilgilerin diğer çalışmalara ışık tutacağına inanmaktayız.

Kaynakça

  • Kaynaklar 1.Horner-Glister E1, Maleki-Dizaji M, Guerin CJ, Johnson SM, StylesJ, White IN Influence of oestradiol and tamoxifen on oestrogen re-ceptors-alpha and -beta protein degradation and non-genomic sig-nalling pathways in uterine and breast carcinoma cells. J Mol En-docrinol. 2005 Dec;35(3):421-32 2.Mendelsohn ME, Karas RH. Molecular and cellular basis of cardio-vascular gender differences. Science 2005; 308:1583-1587. 3.Cauley JA, Seeley DG, Ensrud K, et al. Estrogen Replacement The-rapy and Fractures in Older Women. Annals of Internal Medicine1995; 122:9-16. 4.Mora S, Kershner DW, Vigilance CP, et al. Coronary Artery Disea-se in Postmenopausal Women. Current treatment options in cardio-vascular medicine 2001; 3: 67-79. 5.Riggs BL, Khosla S, Melton LJ. Sex steroids and the construction andconservation of the adult skeleton. Endocrine Reviews 2002;23:279-302. 6.Sherwin BB. Estrogen and cognitive aging in women. Trends in Phar-macological Sciences 2002; 23: 527-53. 7.Feigelson HS, Henderson BE. Estrogens and breast cancer. Carci-nogenesis 1996; 17: 2279-2284 8.Korach KS, Hewitt SC, Couse JF. Estrogen receptor transcription andtransactivation Estrogen receptor knockout mice: what their phenoty-pes reveal about mechanisms of estrogen action. Breast Cancer Re-search 2000; 2: 345-352 9.Green S, Walter P, Greene G, et al. Cloning of the human oestrogenreceptor cDNA. Journal of Steroid Biochemistry 1986; 24: 77-83 10.Kuiper GG, Enmark E, Pelto-Huikko M, et al. Cloning of a novel re-ceptor expressed in rat prostate and ovary. Proceedings of the Na-tional Academy of Sciences of the United States of America 1996;93: 5925-5930 21 11.Ricketts D, Turnbull L, Ryall G, et al. Estrogen and progesterone re-ceptors in the normal female breast. Cancer Research 1991; 51: 1817-1822 12.Leygue E, Dotzlaw H, Watson PH, et al. Altered estrogen receptoralpha and beta messenger RNA expression during human breast tu-morigenesis. Cancer Research 1998; 58: 3197-3201. 13.Ali S, Coombes RC. Estrogen receptor alpha in human breast can-cer: occurrence and significance. Journal of Mammary Gland Bio-logy and Neoplasia 2000; 5: 271-281 14.Khan SA, Rogers MA, Khurana KK, et al. Estrogen receptor expres-sion in benign breast epithelium and breast cancer risk. Journal ofthe National Cancer Institute 1998; 90: 37-42 15.Dahlman-Wright K, Cavailles V, Fuqua SA, et al. International Uni-on of Pharmacology. LXIV. Estrogen receptors. Pharmacological Re-views 2006; 58: 773-781 16.Shiau AK, Barstad D, Loria PM, et al. The structural basis of estro-gen receptor/coactivator recognition and the antagonism of this in-teraction by tamoxifen. Cell 1998; 95: 927-937, 17.Brzozowski AM, Pike AC, Dauter Z, Hubbard RE, Bonn T, EngstromO, Ohman L, Greene GL, Gustafsson JA, and Carlquist M. Molecu-lar basis of agonism and antagonism in the oestrogen receptor. Na-ture. 1997; 389: 753–758. 18.Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, et al. Endoc-rine-Disrupting Chemicals: An Endocrine Society Scientific State-ment. Endocrine Reviews 2009; 30: 293-342 19.O'Reilly EJ, Mirzaei F, Forman MR, et al. Diethylstilbestrol Expo-sure in Utero and Depression in Women. American Journal of Epi-demiology 2010; 171:876-882. 20.Giusti RM, Iwamoto K, Hatch EE. Diethylstilbestrol Revisited - a Re-view of the Long-Term Health-Effects. Annals of Internal Medicine1995; 122:778-788. 21.Warri A, Saarinen N, Makela S, et al. The role of early life geniste-in exposures in modifying breast cancer risk. British Journal of Can-cer 2008; 98: 1485-1493. 22.Messina MJ, Persky V, Setchell KDR, et al. Soy Intake and CancerRisk - a Review of the in-Vitro and in-Vivo Data. Nutrition and Can-cer-an International Journal 1994; 21: 113-131. 23.Matsumura A, Ghosh A, Pope GS, et al. Comparative study of oes-trogenic properties of eight phytoestrogens in MCF7 human breastcancer cells. Journal of Steroid Biochemistry and Molecular Biology2005; 94: 431-443. 24.Ju YH, Allred KF, Allred CD, et al. Genistein stimulates growth ofhuman breast cancer cells in a novel, postmenopausal animal mo-del, with low plasma estradiol concentrations. Carcinogenesis2006; 27: 1292-1299. 25.Booth EA, Marchesi M, Knittel AK, et al. The pathway-selective es-trogen receptor ligand WAY169916 reduces infarct size after myocar-dial ischemia and reperfusion by an estrogen receptor dependent mec-hanism. Journal of Cardiovascular Pharmacology 2007; 49: 401-407 26.Keith JC, Albert LM, Leathurby Y, et al. The utility of pathway se-lective estrogen receptor ligands that inhibit nuclear factor-kappaB transcriptional activity in models of rheumatoid arthritis. Arthri-tis Research & Therapy 2005; 7:R427-R438. 27.Chadwick CC, Chippari S, Matelan E, et al. Identification of path-way-selective estrogen receptor ligands that inhibit NF-kappaB trans-criptional activity. Proceedings of the National Academy of Scien-ces of the United States of America 2005; 102:2543-2548. 28.Bruning JB, Parent AA, Gil G, et al. Coupling of receptor confor-mation and ligand orientation determine graded activity. Nature Che-mical Biology 2010; 6: 837-843 29.Manas ES, Xu ZB, Unwalla RJ, et al. Understanding the selectivityof genistein for human estrogen receptor-beta using X-ray crystal-lography and computational methods. Structure 2004; 12: 2197-2207. 30.Riggs BL, Hartmann LC. Drug therapy: Selective estrogen-receptormodulators - Mechanisms of action and application to clinical prac-tice. New England Journal of Medicine 2003; 348:618629. 31.Blizzard TA, DiNinno F, Morgan JD, et al. Estrogen receptor ligands.Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrro-lidine side chains and linkers. 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The İmportance Of Genetic Polymorphism Of CYP 2D6 İn Breast Cancer Patients Treated With Tamoxifen

Yıl 2018, Cilt: 6 Sayı: 2, 30 - 39, 04.02.2018

Öz

Abstract

Tamoxifen constitutes the cornerstone of the treatment of estrogen receptor positi-ve breast cancer patients. Tamoxifen effectiveness is dependent on the biotransformation. Metabolism is predominantly carried out by the CYP 2D6 isoform and tamoksifen is converted to its active metabolit endoxifen. Both genetic and environmental factors can modify the CYP 2D6 enzyme activity, hence it can directly affect the concentrations of active metabolite of tamoxifen. In a number of studies it has shown CYP 2D6genetic variants may affect the clinical outcomes of patients treated with adjuvant tamoxifen. People in private therapy practice, the link between the CYP 2D6 genotype andthe clinical response of TAM treatment being studied intensively, especially in breast cancer patients. In this review, we tried to summarize themolecular dynamics of CYP 2D6 genetic polymorphism which is associated with tamoxifen treatment response andthe importance of the clinic. We believe this information willshed light on the other studies.

Kaynakça

  • Kaynaklar 1.Horner-Glister E1, Maleki-Dizaji M, Guerin CJ, Johnson SM, StylesJ, White IN Influence of oestradiol and tamoxifen on oestrogen re-ceptors-alpha and -beta protein degradation and non-genomic sig-nalling pathways in uterine and breast carcinoma cells. J Mol En-docrinol. 2005 Dec;35(3):421-32 2.Mendelsohn ME, Karas RH. Molecular and cellular basis of cardio-vascular gender differences. Science 2005; 308:1583-1587. 3.Cauley JA, Seeley DG, Ensrud K, et al. Estrogen Replacement The-rapy and Fractures in Older Women. Annals of Internal Medicine1995; 122:9-16. 4.Mora S, Kershner DW, Vigilance CP, et al. Coronary Artery Disea-se in Postmenopausal Women. Current treatment options in cardio-vascular medicine 2001; 3: 67-79. 5.Riggs BL, Khosla S, Melton LJ. Sex steroids and the construction andconservation of the adult skeleton. Endocrine Reviews 2002;23:279-302. 6.Sherwin BB. Estrogen and cognitive aging in women. Trends in Phar-macological Sciences 2002; 23: 527-53. 7.Feigelson HS, Henderson BE. Estrogens and breast cancer. Carci-nogenesis 1996; 17: 2279-2284 8.Korach KS, Hewitt SC, Couse JF. Estrogen receptor transcription andtransactivation Estrogen receptor knockout mice: what their phenoty-pes reveal about mechanisms of estrogen action. Breast Cancer Re-search 2000; 2: 345-352 9.Green S, Walter P, Greene G, et al. Cloning of the human oestrogenreceptor cDNA. Journal of Steroid Biochemistry 1986; 24: 77-83 10.Kuiper GG, Enmark E, Pelto-Huikko M, et al. Cloning of a novel re-ceptor expressed in rat prostate and ovary. Proceedings of the Na-tional Academy of Sciences of the United States of America 1996;93: 5925-5930 21 11.Ricketts D, Turnbull L, Ryall G, et al. Estrogen and progesterone re-ceptors in the normal female breast. Cancer Research 1991; 51: 1817-1822 12.Leygue E, Dotzlaw H, Watson PH, et al. Altered estrogen receptoralpha and beta messenger RNA expression during human breast tu-morigenesis. Cancer Research 1998; 58: 3197-3201. 13.Ali S, Coombes RC. Estrogen receptor alpha in human breast can-cer: occurrence and significance. Journal of Mammary Gland Bio-logy and Neoplasia 2000; 5: 271-281 14.Khan SA, Rogers MA, Khurana KK, et al. Estrogen receptor expres-sion in benign breast epithelium and breast cancer risk. Journal ofthe National Cancer Institute 1998; 90: 37-42 15.Dahlman-Wright K, Cavailles V, Fuqua SA, et al. International Uni-on of Pharmacology. LXIV. Estrogen receptors. Pharmacological Re-views 2006; 58: 773-781 16.Shiau AK, Barstad D, Loria PM, et al. The structural basis of estro-gen receptor/coactivator recognition and the antagonism of this in-teraction by tamoxifen. Cell 1998; 95: 927-937, 17.Brzozowski AM, Pike AC, Dauter Z, Hubbard RE, Bonn T, EngstromO, Ohman L, Greene GL, Gustafsson JA, and Carlquist M. Molecu-lar basis of agonism and antagonism in the oestrogen receptor. Na-ture. 1997; 389: 753–758. 18.Diamanti-Kandarakis E, Bourguignon JP, Giudice LC, et al. Endoc-rine-Disrupting Chemicals: An Endocrine Society Scientific State-ment. Endocrine Reviews 2009; 30: 293-342 19.O'Reilly EJ, Mirzaei F, Forman MR, et al. Diethylstilbestrol Expo-sure in Utero and Depression in Women. American Journal of Epi-demiology 2010; 171:876-882. 20.Giusti RM, Iwamoto K, Hatch EE. Diethylstilbestrol Revisited - a Re-view of the Long-Term Health-Effects. Annals of Internal Medicine1995; 122:778-788. 21.Warri A, Saarinen N, Makela S, et al. The role of early life geniste-in exposures in modifying breast cancer risk. British Journal of Can-cer 2008; 98: 1485-1493. 22.Messina MJ, Persky V, Setchell KDR, et al. Soy Intake and CancerRisk - a Review of the in-Vitro and in-Vivo Data. Nutrition and Can-cer-an International Journal 1994; 21: 113-131. 23.Matsumura A, Ghosh A, Pope GS, et al. Comparative study of oes-trogenic properties of eight phytoestrogens in MCF7 human breastcancer cells. Journal of Steroid Biochemistry and Molecular Biology2005; 94: 431-443. 24.Ju YH, Allred KF, Allred CD, et al. Genistein stimulates growth ofhuman breast cancer cells in a novel, postmenopausal animal mo-del, with low plasma estradiol concentrations. Carcinogenesis2006; 27: 1292-1299. 25.Booth EA, Marchesi M, Knittel AK, et al. The pathway-selective es-trogen receptor ligand WAY169916 reduces infarct size after myocar-dial ischemia and reperfusion by an estrogen receptor dependent mec-hanism. Journal of Cardiovascular Pharmacology 2007; 49: 401-407 26.Keith JC, Albert LM, Leathurby Y, et al. The utility of pathway se-lective estrogen receptor ligands that inhibit nuclear factor-kappaB transcriptional activity in models of rheumatoid arthritis. Arthri-tis Research & Therapy 2005; 7:R427-R438. 27.Chadwick CC, Chippari S, Matelan E, et al. Identification of path-way-selective estrogen receptor ligands that inhibit NF-kappaB trans-criptional activity. Proceedings of the National Academy of Scien-ces of the United States of America 2005; 102:2543-2548. 28.Bruning JB, Parent AA, Gil G, et al. Coupling of receptor confor-mation and ligand orientation determine graded activity. Nature Che-mical Biology 2010; 6: 837-843 29.Manas ES, Xu ZB, Unwalla RJ, et al. Understanding the selectivityof genistein for human estrogen receptor-beta using X-ray crystal-lography and computational methods. Structure 2004; 12: 2197-2207. 30.Riggs BL, Hartmann LC. Drug therapy: Selective estrogen-receptormodulators - Mechanisms of action and application to clinical prac-tice. New England Journal of Medicine 2003; 348:618629. 31.Blizzard TA, DiNinno F, Morgan JD, et al. Estrogen receptor ligands.Part 9: Dihydrobenzoxathiin SERAMs with alkyl substituted pyrro-lidine side chains and linkers. Bioorganic & Medicinal ChemistryLetters 2005; 15: 107-113. 32.Johnston SJ1, Cheung KL Fulvestrant - a novel endocrine therapyfor breast cancer. Curr Med Chem. 2010;17(10):902-14. 33.Dodwell D1, Vergote I A comparison of fulvestrant and the third-ge-neration aromatase inhibitors in the second-line treatment of post-menopausal women with advanced breast cancer. Cancer Treat Rev.2005 Jun;31(4):274-82. 34.C. Kalyana Kumar, Mohan Reddy, Kaiser Jamil* and Mohana VamsyGenotyping of tamoxifen metabolizing enzyme(CYP 2D6*4) and itsclinical impact in breast cancerpatients. 35.Osborne CK (1998) Tamoxifen in the treatment of breast cancer. NEngl J Med 339(22):1609–1618. 36.Early Breast Cancer Trialists’ Collaborative Group (2005) Effectsof chemotherapy and hormonal therapy for early breast cancer onrecurrence and 15-year survival: an overview of the randomised tri-als. Lancet 365(9472):1687–1717. 37.Precigoux G, Courdeille, C., Geoffre, S., and Hospital, M., 1979 ActaCryst. 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Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler 1
Yazarlar

Selina Toplayıcı Bu kişi benim

Yayımlanma Tarihi 4 Şubat 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 6 Sayı: 2

Kaynak Göster

APA Toplayıcı, S. (2018). Tamoksifenle Tedavi Edilen Meme Kanser Hastalarında CYP 2D6 Genetik Polimorfizminin Önemi. Klinik Tıp Bilimleri, 6(2), 30-39.
AMA Toplayıcı S. Tamoksifenle Tedavi Edilen Meme Kanser Hastalarında CYP 2D6 Genetik Polimorfizminin Önemi. Klinik Tıp Bilimleri. Şubat 2018;6(2):30-39.
Chicago Toplayıcı, Selina. “Tamoksifenle Tedavi Edilen Meme Kanser Hastalarında CYP 2D6 Genetik Polimorfizminin Önemi”. Klinik Tıp Bilimleri 6, sy. 2 (Şubat 2018): 30-39.
EndNote Toplayıcı S (01 Şubat 2018) Tamoksifenle Tedavi Edilen Meme Kanser Hastalarında CYP 2D6 Genetik Polimorfizminin Önemi. Klinik Tıp Bilimleri 6 2 30–39.
IEEE S. Toplayıcı, “Tamoksifenle Tedavi Edilen Meme Kanser Hastalarında CYP 2D6 Genetik Polimorfizminin Önemi”, Klinik Tıp Bilimleri, c. 6, sy. 2, ss. 30–39, 2018.
ISNAD Toplayıcı, Selina. “Tamoksifenle Tedavi Edilen Meme Kanser Hastalarında CYP 2D6 Genetik Polimorfizminin Önemi”. Klinik Tıp Bilimleri 6/2 (Şubat 2018), 30-39.
JAMA Toplayıcı S. Tamoksifenle Tedavi Edilen Meme Kanser Hastalarında CYP 2D6 Genetik Polimorfizminin Önemi. Klinik Tıp Bilimleri. 2018;6:30–39.
MLA Toplayıcı, Selina. “Tamoksifenle Tedavi Edilen Meme Kanser Hastalarında CYP 2D6 Genetik Polimorfizminin Önemi”. Klinik Tıp Bilimleri, c. 6, sy. 2, 2018, ss. 30-39.
Vancouver Toplayıcı S. Tamoksifenle Tedavi Edilen Meme Kanser Hastalarında CYP 2D6 Genetik Polimorfizminin Önemi. Klinik Tıp Bilimleri. 2018;6(2):30-9.