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Araştırma Makalesi
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Ailevi Hiperkolesterolemi: Epidemiyoloji, Genetik, Tanı Ve Tedavisi

Yıl 2020, Cilt: 8 Sayı: 2, 62 - 66, 05.07.2022

Öz

Lipoprotein 2 metabolizmasının genetik bir bozukluğu olan ailevi hiperlipidemi
artmış kolesterol seviyeleri ve erken gelişen kardiyovasküler hastalıklarla kendini gösterir.
Homozigot ve heterozigot formları mevcut olup, özellikle fenotipik hafif formu
olan heterozigot tip klinik tanıda genellikle göz ardı edilmektedir. Tanı laboratuvar
testleri, fenotipik değerlendirme ve genetik mutasyon analizleri ile yapılmaktadır.
Tedavide yükselmiş düşük dansiteli kolesterol seviyesinin düşürülmesi amaçlanır.
Yöntem olarak statinlerden afereze, diyet, egzersize ve karaciğer nakline kadar
geniş bir yelpaze bulunmaktadır. Primer korumada ise hastaların genetik olarak
saptanması ve akraba evliliklerinin önlenmesi dışında yapılabilecek bir şey yoktur.
Ülkemizde genetik mutasyonlar kısıtlı çalışmalarda araştırılmış, bu nedenle mutasyon
sıklık ve çeşidi konusunda bilgimiz sınırlıdır. Bu derlemede bu hastalığın tanı,
tedavi ve yönetimi konusunda güncel bilgiler verilmiştir.

Kaynakça

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Toplam 81 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Makaleler 1
Yazarlar

Hakan Göçer Bu kişi benim

Murat Günday Bu kişi benim

Ahmet Barış Durukan Bu kişi benim

Yayımlanma Tarihi 5 Temmuz 2022
Yayımlandığı Sayı Yıl 2020 Cilt: 8 Sayı: 2

Kaynak Göster

APA Göçer, H., Günday, M., & Durukan, A. B. (2022). Ailevi Hiperkolesterolemi: Epidemiyoloji, Genetik, Tanı Ve Tedavisi. Klinik Tıp Bilimleri, 8(2), 62-66.
AMA Göçer H, Günday M, Durukan AB. Ailevi Hiperkolesterolemi: Epidemiyoloji, Genetik, Tanı Ve Tedavisi. Klinik Tıp Bilimleri. Temmuz 2022;8(2):62-66.
Chicago Göçer, Hakan, Murat Günday, ve Ahmet Barış Durukan. “Ailevi Hiperkolesterolemi: Epidemiyoloji, Genetik, Tanı Ve Tedavisi”. Klinik Tıp Bilimleri 8, sy. 2 (Temmuz 2022): 62-66.
EndNote Göçer H, Günday M, Durukan AB (01 Temmuz 2022) Ailevi Hiperkolesterolemi: Epidemiyoloji, Genetik, Tanı Ve Tedavisi. Klinik Tıp Bilimleri 8 2 62–66.
IEEE H. Göçer, M. Günday, ve A. B. Durukan, “Ailevi Hiperkolesterolemi: Epidemiyoloji, Genetik, Tanı Ve Tedavisi”, Klinik Tıp Bilimleri, c. 8, sy. 2, ss. 62–66, 2022.
ISNAD Göçer, Hakan vd. “Ailevi Hiperkolesterolemi: Epidemiyoloji, Genetik, Tanı Ve Tedavisi”. Klinik Tıp Bilimleri 8/2 (Temmuz 2022), 62-66.
JAMA Göçer H, Günday M, Durukan AB. Ailevi Hiperkolesterolemi: Epidemiyoloji, Genetik, Tanı Ve Tedavisi. Klinik Tıp Bilimleri. 2022;8:62–66.
MLA Göçer, Hakan vd. “Ailevi Hiperkolesterolemi: Epidemiyoloji, Genetik, Tanı Ve Tedavisi”. Klinik Tıp Bilimleri, c. 8, sy. 2, 2022, ss. 62-66.
Vancouver Göçer H, Günday M, Durukan AB. Ailevi Hiperkolesterolemi: Epidemiyoloji, Genetik, Tanı Ve Tedavisi. Klinik Tıp Bilimleri. 2022;8(2):62-6.