Fibromiyalji Hastalarında Serum Homosistein Düzeyleri ile Hastalık Aktivitesi Arasındaki İlişki

Abstract

Amaç: Fibromiyalji sendromu (FMS), çok çeşitli semptomları olan bir romatizmal hastalıktır. Yüksek homosistein (Hcy) düzeyleri; böbrek fonksiyon bozuklukları, kardiyovasküler hastalıklar, vitiligo, kanser, diyabet, iskemik inme, epilepsi, demans, otizm ve çeşitli nörolojik bozukluklarla ilişkilendirilmiştir. Bu retrospektif çalışma, FMS'nin etiyolojisinde Hcy'nin rolünü ve hastalık aktivitesi ile ilişkisini değerlendirmek amacıyla yapılmıştır. Yöntem: Çalışmamıza, Amerikan Romatoloji Koleji 2010 kriterlerine göre FMS tanısı konmuş 42 kadın hasta dahil edildi. Yaşları hasta grubuyla benzer 20 sağlıklı kadın, kontrol grubunu oluşturmuştur. Tüm hastaların ve kontrol grubundaki katılımcıların ayrıntılı anamnez ve sosyodemografik verileri kaydedildi. Tüm hastalarda ve kontrol grubunda hemogram, rutin biyokimya, vitamin B12, folik asit, tiroid fonksiyon testleri, eritrosit sedimantasyon hızı (ESR), C-reaktif protein (CRP), 25-hidroksi vitamin D ve serum Hcy düzeyleri hasta dosyasından kaydedildi. Bulgular: Serum Hcy, CRP ve ESR düzeyleri, FMS grubunda kontrol grubuna göre istatistiksel olarak daha yüksekti (sırasıyla p=0,003, p=0,004 ve p=0,011). Ancak, Hcy düzeyleri ile Fibromiyalji Etki Anketi, Vizüel Analog Skala, Beck Depresyon Envanteri, Pittsburgh Uyku Kalitesi İndeksi veya Kısa Form-36 skorları arasında istatistiksel olarak anlamlı bir korelasyon yoktu. Sonuç: FMS, etiyolojisi aydınlatılamamış kompleks bir hastalıktır. FMS'nin birden fazla sistemi etkilediği ve Hcy’nin çeşitli fizyolojik süreçlerde rol oynadığı göz önüne alındığında FMS ile Hcy arasındaki ilişkiyi açıklamak için daha kapsamlı çalışmalara ihtiyaç vardır.

Keywords

• fibromiyalji
• Homosistein
• Hastalık aktivitesi

Relationship between Serum Homocysteine Levels and Disease Activity in Patients with Fibromyalgia

Abstract

Objective: Fibromyalgia syndrome (FMS) is a rheumatic disorder characterized by a wide spectrum of symptoms. Elevated homocysteine (Hcy) levels have been associated with a variety of conditions including renal dysfunction, cardiovascular disease, vitiligo, cancer, diabetes, ischemic stroke, epilepsy, dementia, autism, and various neurological disorders. This retrospective study aimed to evaluate the role of Hcy in the etiology of FMS and its relationship with disease activity. Method: This study included 42 female patients diagnosed with FMS according to the American College of Rheumatology 2010 criteria, along with 20 age-matched healthy female controls. Detailed medical history and sociodemographic data were collected from all participants. Hemogram, routine biochemical tests, vitamin B12, folic acid, thyroid function tests, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), 25-hydroxy vitamin D, and serum Hcy levels were recorded from medical files in both groups. Results: Serum Hcy, CRP, and ESR levels were significantly higher in the FMS group compared to controls (p=0.003, p=0.004, and p=0.011, respectively). However, no statistically significant correlation was found between Hcy levels and Fibromyalgia Impact Questionnaire, Visual Analog Scale, Beck Depression Inventory, Pittsburgh Sleep Quality Index, or Short Form-36 scores. Conclusions: FMS is a complex disease with an unclear etiology. Considering that FMS affects multiple systems and that Hcy plays a role in various physiological processes, further comprehensive studies are warranted to elucidate the relationship between FMS and Hcy.

Keywords

• Fibromyalgia
• Homocysteine
• Disease Activity

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